Global Peptide Vaccine Market Sales Revenue Clinical Trials Pipeline Report 2020

The outline of human vaccines had an incredible impact on global health system which resulted in intense reduction of mortality and morbidity caused by numerous diseases. Vaccines have led to some of the greatest public health achievements ever, including the eradication of naturally occurring smallpox from the globe and the near eradication of polio. This prophylaxis had a long journey through various roads and tunnels to become the humanities’ key achievement. Despite of the fact, that its mechanism of action remained unclear for centuries. New vaccines coined up in nineteenth century and after the expanded studies of infectious diseases and processed microorganism vaccination has become an intensive subject to be studied. By all the new advances towards the discovery and understanding of various diseases, our species was able to find a way to eradicate them.

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"Peptide Vaccine Market & Clinical Pipeline Outlook 2020"
Table of Contents

1. Peptide Vaccine: A Prologue to Sub-Unit Vaccines
1.1 Introduction
1.2 Glimpse of Antiquity

2. Need of Peptide Vaccines
2.1 Why Peptides – More Desirable
2.2 Peptide Vaccines V/S Traditional Vaccines

3. Classification of Peptide Vaccines
3.1 On the Basis of Sources Obtained
3.2 On the Basis of Length
3.3 On the Basis of Epitopes

4. Designing & Production of Peptide Vaccine
4.1 Synthetic Peptide Vaccine
4.2 Selection of Peptide Antigen
4.3 Construction of Peptide Antigen
4.4 Chemical Synthesis of Peptide Vaccine
4.4.1 Solution Phase Synthesis (SPS)
4.4.2 Solid Phase Peptide Synthesis (SPPS)

5. Mechanism of Peptide Vaccine
5.1 Induction of Immune Response
5.1.1 Factors Affecting T-Cell Stimulation
5.1.2 Factors Affecting B-cell Stimulation
5.1.3 Factors Affecting T-helper Cells
5.2 Delivery System for Peptide Vaccines
5.2.1 Immunostimulatory Adjuvants
5.2.2 Vaccine Delivery System
5.3 Multiple Antigen Peptide System (MAP)
5.3.1 Use of MAP for Foot-and-Mouth Disease

6. Cancer Immunotherapy with Peptide Vaccine
6.1 Peptides as Tumor Antigens
6.2 Immunotherapy with Peptide Vaccination
6.3 Therapeutic Evaluation of Peptide Vaccine
6.3.1 Prostate Cancer
6.3.2 Breast Cancer
6.3.3 Gastric Cancer
6.3.4 Lung Cancer
6.3.5 Pancreatic Cancer

7. Global Peptide Vaccine Market Overview
7.1 Peptide Vaccine – Does have Long & Secure Future?
7.2 Peptide Patents Insights
7.3 Peptide Vaccine Pipeline Overview

8. Global Peptide Vaccine Market Dynamics
8.1 Accelerative Parameters
8.1.1 Peptidomics
8.1.2 Advances in Vaccine Research
8.1.3 Stronger Clinical Pipeline
8.1.4 Emergence of Biologics in Cancer Therapy
8.2 Commercialization Challenges & Modifications
8.2.1 Funding & Legal Issues
8.2.2 Designing & Manufacturing Challenges
8.2.3 Route of Administration
8.2.4 Peptide Pharmacodynamics & Pharmacokinetics

9. Global Peptide Vaccine Market Future Perspectives

10. Global Peptide Vaccine Clinical Pipeline by Company, Indication & Phase
10.1 Research
10.2 Preclinical
10.3 Phase-I
10.4 Phase-I/II
10.5 Phase-II
10.6 Phase-III

11. Discontinued & Suspended Peptide Vaccine Clinical Pipeline by Company, Indication & Phase
11.1 No Development Reported
11.2 Discontinued
11.3 Market Withdrawal
11.4 Suspended

12. Competitive Landscape
12.1 AFFiRiS
12.2 AlerGenetica
12.3 Anergis
12.4 Antigen Express
12.5 Apitope Technology
12.6 Araclon Biotech
12.7 Artificial Cell Technologies
12.8 Benovus Bio
12.9 Bionor Pharma
12.10 Circassia
12.11 Celgene Corporation
12.12 Galena Biopharma
12.13 Immatics biotechnologies
12.14 Immune Design
12.15 ImmunoCellular Therapeutics
12.16 Invectys
12.17 ISA Pharmaceuticals
12.18 Lytix Biopharma
12.19 Medinet
12.20 Spotlight Innovation (Memcine Pharmaceuticals)
12.21 Merck Serono
12.22 OncoTherapy Science
12.23 Peptech
12.24 Peptinov
12.25 PeptiVir
12.26 Pharmasyntez
12.27 Renaptys Vaccines
12.28 Sumitomo Dainippon Pharma
12.29 TapImmune
12.30 Targovax
12.31 Vaxon Biotech

Figure 1-1: History of Vaccines
Figure 2-1: Peptides - Amino Acid & Proteins
Figure 2-2: Diversification of Vaccines
Figure 2-3: Sub-Unit Vaccines V/S Traditional Vaccines
Figure 3-1: Classification of Peptide Vaccine by Source
Figure 3-2: Classification on Basis of Length
Figure 3-3: On the Basis of Epitopes
Figure 4-1: Synthetic Peptide Manufacturing Process
Figure 4-2: Selection of Synthetic Immunogenic Constructs
Figure 4-3: Solid phase Peptide Synthesis v/s Solution Phase Technique.
Figure 4-4: Fmoc Cleavage
Figure 4-5: Boc Cleavage
Figure 5-1: Mechanism of Immune Activation of CD4+ and CD8+ T-Cells
Figure 5-2: Delivery System Pathways by Adjuvants
Figure 5-3: Liposome & the Modes of Chemically Different Antigen Incorporation.
Figure 6-1: TAAs on the Basis of Tissue Distribution
Figure 6-2: Vaccination via Peptide Loaded Dendritic Cells
Figure 6-3: Mechanism of Action of Sipuleucel-T
Figure 6-4: Use of HER-Vaxx Antigen for Production of Antibodies
Figure 6-5: Peptides Applied in Treating Cancer
Figure 7-1: Global Peptide Drug Market (US$ Billion), 2014-2020
Figure 7-2: Approved Peptide Drugs
Figure 7-3: Global - Peptide Vaccine Clinical Pipeline by Phase (%), 2016
Figure 7-4: Global - Peptide Vaccine Clinical Pipeline by Phase (Numbers), 2016
Figure 7-5: Global - Active & Suspended Peptide Vaccine Clinical Pipeline by Phase (%), 2016
Figure 7-6: Global - Active & Suspended Peptide Vaccine Clinical Pipeline by Phase (Numbers), 2016
Figure 8-1: Global - Peptide Market Favorable Parameters
Figure 8-2: Global - Peptide Vaccine Market Commercialization Challenges
Figure 8-3: Routes of Administration
Figure 12-1: Anergis – Clinical Pipeline
Figure 12-2: Apitope Technology – Clinical Pipeline
Figure 12-3: Benovus Bio – Clinical Pipeline
Figure 12-4: Bionor Pharma – Clinical Pipeline
Figure 12-5: Circassia – Clinical Pipeline
Figure 12-6: Celgene - Clinical Pipeline
Figure 12-7: Galena Biopharma - Clinical Pipeline
Figure 12-8: Immatics Biotechnologies - Clinical Pipeline
Figure 12-9: Immune Design – Clinical Pipeline
Figure 12-10: ImmunoCellular Therapeutics - Clinical Pipeline
Figure 12-11: Invectys – Clinical Pipeline
Figure 12-12: ISA Pharmaceuticals – Clinical Pipeline
Figure 12-13: Lytix Biopharma - Clinical Pipeline
Figure 12-14: Merck Serono – Clinical Pipeline
Figure 12-15: Onco Therapy Science – Clinical Pipeline
Figure 12-16: Peptinov - Clinical Pipeline
Figure 12-17: Sumitomo Dainippon Pharma – Clinical Pipeline
Figure 12-18: Tapimmune – Clinical Pipeline
Figure 12-19: Targovax - Clinical Pipeline
Figure 12-20: Vaxon Biotech - Clinical Pipeline

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