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Various Targets for the Disease Treatment Drives the Growth of Uveitis Therapeutics Pipeline
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Insights on pipeline segments
As per the findings of the research, around 37.0% of active drug candidates of uveitis pipeline are being developed to be administered by topical route, 12.0% are being developed by intravitreal route and 18.0% are to be administered by other routes such as oral, subcutaneous and intravenous. Route of administration of around 33.0% active drug candidates of uveitis pipeline is not disclosed.
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Durasert technology platform for Uveitis drug development
pSivida Corp. is using durasert technology platform for the development of Medidur for the treatment of uveitis. This technology platform is used to provide sustained, localized delivery of drugs to the back of the eye. Durasert products are developed with a drug core surrounded with one or more polymer layers, the permeability of those layers and other aspects of the design of the product, controls the rate and duration of the drug release. However, changing the elements of the design, can help in altering both the rate and duration of release to meet different therapeutic needs. The later generation durasert products and product candidates are injected at the target site, while early generations were surgically implanted.
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The research also found that various companies received grants for the development of uveitis therapeutics pipeline. In March 2017, Elasmogen Ltd. received a Biomedical Catalyst Grant from the U.K. innovation agency, Innovate UK and matching investment from Deepbridge Capital and Scottish Investment Bank (the investment arm of Scottish Enterprise) for developing ELN-21 and ELN-22 to be used in topical treatment of ocular disease. In August 2015, TxCell SA received a grant from French government’s Unique Interministerial Fund (FUI) to the TRUST project (TRegs in Uveitis STudy). The grant would be used to process and support clinical development of Col-Treg.
Some of the key players developing drugs for the treatment of uveitis include Alcon Research, Ltd., Enzo Biochem Inc., Mitotech, SA, EyeGate Pharmaceuticals, Inc., Aldeyra Therapeutics, Inc., pSivida Corp. and Santen Inc.
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