Induced Pluripotent Stem Cell (iPSC) Industry: Key Trends, Clinical Trial And Scientific Publication Trends

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Recent months have seen the first iPSC clinical trial in humans, creation of the world’s largest iPSC biobank, major funding awards, a historic challenge to the “Yamanaka Patent”, a Supreme Court ruling affecting industry patent rights, announcement of an iPSC cellular therapy clinic scheduled to open in 2019, and much more. Furthermore, iPSC patent dominance continues to cluster in specific geographic regions, while clinical trial and scientific publication trends give clear indicators of what may happen in the industry in 2015 and beyond. Is it worth it to get informed about rapidly-evolving market conditions and identify key industry trends that will give you an advantage over your competition?

REPORT APPLICATIONS

This global strategic report is produced for:
Management of Stem Cell Product Companies
Management of Stem Cell Therapy Companies
Stem Cell Industry Investors
It is designed to increase your efficiency and effectiveness in:
Commercializing iPSC products, technologies, and therapies
Making intelligent investment decisions
Launching high-demand products
Selling effectively to your client base
Increasing revenue
Taking market share from your competition

OVERVIEW

Stem cell research and experimentation have been in process for well over five decades, as stem cells have the unique ability to divide and replicate repeatedly. In addition, their “unspecialized” nature allows them to differentiate into a wide variety of specialized cell types. The possibilities arising from these characteristics have resulted in great commercial interest, with potential applications ranging from the use of stem cells in reversal and treatment of disease, to targeted cell therapy, tissue regeneration, pharmacological testing on cell-specific tissues, and more.

Discovery of Induced Pluripotent Stem Cells

Groundbreaking experimentation in 2006 led to the introduction of induced pluripotent stem cells (iPSCs). These are adult cells which are isolated and then transformed into embryonic-like stem cells through the manipulation of gene expression, as well as other methods. Research and experimentation using mouse cells by Shinya Yamanaka’s lab at Kyoto University in Japan was the first instance in which there was successful generation of iPSCs. In 2007, a series of follow-up experiments was done at Kyoto University in which human adult cells were transformed into iPSC cells. Nearly simultaneously, a research group led by James Thomson at the University of Wisconsin-Madison accomplished the same feat of deriving iPSC lines from human somatic cells.

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Landmark Events Create Market Opportunities for iPSCs

In 2009 ReproCELL, a company established as a venture company originating from the University of Tokyo and Kyoto University, was the first to make iPSC product commercially available with the launch of human iPSC-derived cardiomyocytes, which it called “ReproCario.” ReproCELL has since furthered its dominance in the area of iPSC products through a series of strategic acquisitions, including acquisition of Reinnervate, Stemgent, and BioServe Biotechnologies.

Primary Areas of Commercialization

There are currently four major areas of commercialization for induced pluripotent stem cells:
1) Drug Development & Discovery: iPSCs have the potential to transform drug discovery by providing physiologically relevant cells for compound identification, target validation, compound screening, and tool discovery.
2) Cellular Therapy: iPSCs can be used for cellular therapy applications, including autologous transplantation and potentially gene therapy. The purpose of cellular therapy is to reverse injury or disease.

While competition is fierce in each of these areas, with the market leaders for each category are shown below:

Drug Development and Discovery: Cellular Dynamics International (CDI) in Madison, Wisconsin
Cellular Therapy (Therapeutic Applications of iPSCs): RIKEN Center, in Kobe, Japan, and Kyoto University in Kyoto, Japan

End-User Survey of iPSC Researchers

Since the discovery of iPSCs a large and thriving research product market has grown into existence, largely because the cells are completely non-controversial and can be generated directly from adult cells. Today, the number of iPSC products sold worldwide is increasing with double-digit growth. In addition, 22% of all stem cell researchers now self-report having used iPSCs within a research project. It is clear that iPSCs represent a lucrative product market, but methods for commercializing this cell type are still being explored, as clinical studies investigating iPSCs continue to increase in number.

Key report findings include:

Metrics, Timelines, Tables, and Graphs for the iPSC Industry
Trend Rate Data for iPSC Grants, Clinical Trials, and Scientific Publications
Analysis of iPSC Patent Environment, including Key Patents and Patent Trends
Market Segmentation
5-Year Market Size Projections (2015-2019)
Market Size Estimations, by Market Segment
Updates on Crucial iPSC Industry and Technology Trends

Input Sources

The content and statistics contained in this report were compiled using:
Stem Cell Grant Funding Database (NIH database)
Stem Cell Patent Database (USPTO)
Stem Cell Clinical Trial Database (ClinicalTrials.gov)
Stem Cell Scientific Publication Database (PubMed)

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