DNA Synthesis Market Growth Accelerates at 12.3% CAGR Through 2033 | Persistence Market Research

The DNA synthesis market, which plays a crucial role in a wide range of industries, including pharmaceuticals, biotechnology, diagnostics, and research, is poised for significant growth over the next decade. By 2026, the global DNA synthesis market is projected to reach a value of USD 3.7 billion, and it is expected to grow at a compound annual growth rate (CAGR) of 12.3%, ultimately reaching USD 8.3 billion by 2033. This robust growth is being propelled by various innovations in gene-editing technologies, expanding therapeutic applications, and the increasing need for customized DNA synthesis solutions. The demand for synthetic DNA is being driven by the growing interest in personalized medicine, CRISPR technologies, and gene therapy, all of which rely on high-quality, precisely synthesized genetic material.

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Key Growth Drivers Behind Market Expansion

The DNA synthesis market's expansion is underpinned by three key drivers: the commercialization of CRISPR-based therapies, the increasing use of synthetic biology in various industries, and the rapid growth of personalized medicine. As CRISPR-based therapies move from research labs to clinical applications, there is a rising demand for specialized DNA synthesis services. This includes the creation of guide RNA, donor DNA, and the manufacturing of therapeutic DNA constructs, which are all critical to CRISPR's success. Additionally, advancements in gene synthesis technologies, such as enzymatic platforms and array-based synthesis, have drastically reduced costs and increased scalability, making DNA synthesis more accessible to a broader range of industries. Furthermore, the integration of DNA synthesis with personalized medicine offers significant growth potential as healthcare systems increasingly adopt genetic testing and tailored therapies.

Leading Segment and Geographical Insights

Among the various segments within the DNA synthesis market, oligonucleotides currently dominate, accounting for 27% of the market share in 2025. These synthetic DNA fragments are integral to PCR, diagnostics, and therapeutic applications. However, gene synthesis is the fastest-growing segment, with a projected CAGR of over 15% through 2032. This growth is largely driven by the rising demand for gene therapy, CRISPR guide RNA, and synthetic biology applications, all of which require high-quality, custom-designed genetic material.

Geographically, North America holds the largest share of the DNA synthesis market, with a 34% share in 2025. This is attributed to the region's well-established biotechnology infrastructure, robust funding from institutions like the National Institutes of Health (NIH), and the commercialization of CRISPR-based therapies following the approval of Casgevy, the first CRISPR medicine for sickle cell disease in late 2023. On the other hand, Asia-Pacific is expected to register the highest growth rate, with a projected CAGR of 19.7% through 2033. This growth is attributed to cost-efficient manufacturing, government-backed initiatives supporting gene-editing research, and increasing investments in biotechnology across the region.

Key Highlights from the Report

• North America leads the DNA synthesis market, holding a 34% share in 2025.
• Asia-Pacific is the fastest-growing region, projected to grow at a CAGR of 19.7% through 2033.
• Oligonucleotides will dominate the market in 2025, representing 27% of market share.
• Gene synthesis is the fastest-growing segment in the market.
• Personalized DNA synthesis offers significant growth potential, especially in therapeutic applications.
• The market is set to reach USD 8.3 billion by 2033, driven by advancements in CRISPR and synthetic biology.

Market Segmentation

The DNA synthesis market can be segmented based on product type, end-user, and region. The product types in this market include oligonucleotides, gene synthesis, and custom DNA libraries. Oligonucleotides, with their broad applications across PCR, diagnostics, and therapeutics, dominate the market in terms of revenue. Gene synthesis, however, is the fastest-growing segment due to its critical role in CRISPR-based therapies, gene therapy, and synthetic biology applications.

In terms of end-users, the largest share of the market is held by biopharmaceutical companies. These organizations use DNA synthesis extensively for drug discovery, genetic research, and therapeutic development. Academic and research institutions also represent a significant portion of the market, with increasing government and private sector funding for genomics research. Furthermore, clinical laboratories are emerging as a growing end-user segment, driven by the increasing use of genetic testing in diagnostics and personalized medicine.

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Regional Insights

North America continues to dominate the DNA synthesis market, benefiting from well-established biopharmaceutical sectors, cutting-edge research facilities, and a favorable regulatory environment. The U.S. in particular remains a global leader in the adoption of CRISPR technologies, gene therapy, and synthetic biology, fueling demand for specialized DNA synthesis services. Moreover, North America's strong academic-industrial collaborations and high levels of public and private investment in life sciences further support the region's leadership.

In contrast, Asia-Pacific is quickly emerging as a key player in the DNA synthesis market, particularly in countries like China, India, and Japan. These nations are making substantial investments in biotechnology research and infrastructure, and they benefit from cost-effective manufacturing practices that are appealing to both domestic and global markets. Government support for biotechnology initiatives, along with a growing network of contract research organizations, is accelerating the market's expansion in this region. Over time, Asia-Pacific is expected to transition from a cost-driven supplier region into a major consumer market for DNA synthesis services.

Market Drivers

Several key drivers are propelling the growth of the DNA synthesis market. One of the primary factors is the rapid advancement of CRISPR technologies, which have revolutionized gene editing and are now being applied in clinical settings. As CRISPR-based therapies move beyond research and into the clinic, the demand for precise and high-quality synthetic DNA will continue to increase. Additionally, the rising adoption of synthetic biology in fields like agriculture, environmental science, and energy production is driving demand for DNA constructs capable of modifying biological systems.

The expansion of personalized medicine is another critical driver for the DNA synthesis market. With the increasing focus on genomics and tailored therapies, healthcare providers are seeking customized DNA sequences to develop treatments that are specifically designed for individual patients. This trend is expected to lead to higher margins for DNA synthesis providers, particularly those specializing in personalized or variant-specific DNA synthesis.

Market Restraints

Despite its growth potential, the DNA synthesis market faces several constraints. One of the most significant challenges is the manufacturing complexity and cost associated with therapeutic-grade DNA synthesis. For example, the coupling efficiency of phosphoramidite chemistry, which is the most commonly used method for DNA synthesis, declines as the sequence length increases. This results in higher costs and lower yields for long, complex sequences required by gene therapies. Additionally, the need for Good Manufacturing Practice (GMP) certification for therapeutic applications adds considerable cost and complexity to the manufacturing process.

Another challenge lies in the supply chain, which is highly concentrated in certain geographic regions, particularly China and the U.S. Trade tensions, regulatory restrictions, and geopolitical issues can create uncertainties and disrupt the supply of critical materials and technologies. This is a concern for DNA synthesis companies, particularly those looking to scale their operations or expand into new markets.

Market Opportunities

The DNA synthesis market offers significant opportunities, particularly in the area of personalized medicine. As genomic sequencing technologies advance, the ability to tailor treatments to an individual's genetic makeup is becoming more feasible and cost-effective. This shift toward personalized therapies is expected to drive the demand for custom DNA synthesis, particularly for rare genetic disorders, cancer, and other complex diseases.

In addition to personalized medicine, the market is also poised to benefit from the growing interest in synthetic biology and gene editing technologies. These innovations are opening up new possibilities in agriculture, environmental science, and industrial biotechnology, which will require large-scale, high-quality DNA synthesis services. Furthermore, the integration of companion diagnostics and the rise of genomic data analytics offer additional opportunities for DNA synthesis providers to capture value through end-to-end service models that combine DNA synthesis with clinical validation and therapeutic development.

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Company Insights

The DNA synthesis market is home to several key players, each of whom is focused on technological innovation, operational efficiency, and geographic expansion. Key companies operating in the market include:

• Brooks Automation, Inc. (GENEWIZ)
• Boster Biological Technology
• ProteoGenix
• Biomatik
• ProMab Biotechnologies, Inc.
• Thermo Fisher Scientific, Inc.
• Integrated DNA Technologies, Inc.
• OriGene Technologies, Inc.

Market Segmentation

By Product

Oligonucleotides (short DNA sequences)
Gene synthesis (custom genes)
DNA libraries
Reagents & kits
Instruments & synthesizers

By Application

Research & Development (R&D)
Diagnostics
Therapeutics
Academic use
Industrial use

By End-user

Biotech & pharma companies
Academic & research institutes
Contract research organizations (CROs)
Clinical laboratories

By Region

North America
Europe
Asia Pacific
Latin America
Middle East & Africa

Recent Developments

In October 2025, Ribbon Bio and Scala Biodesign announced a partnership to enhance DNA synthesis capabilities. This collaboration focuses on improving enzyme delivery systems to accelerate DNA synthesis and expand their reach in global markets.

Thermo Fisher Scientific recently launched an advanced DNA synthesis platform, designed to provide faster, more accurate sequencing for gene therapy applications, further solidifying its leadership in the market.

Conclusion

The DNA synthesis market is on the cusp of transformative growth, fueled by advancements in CRISPR technology, synthetic biology, and personalized medicine. As the demand for customized genetic material increases across biopharmaceutical, diagnostic, and research sectors, companies operating in this space will continue to innovate and expand their capabilities. While the market faces challenges such as manufacturing complexity and supply chain risks, the opportunities in personalized therapies and synthetic biology are too significant to overlook. As a result, the DNA synthesis market is well-positioned to experience sustained growth over the next decade, driven by both technological advances and shifting healthcare paradigms.

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