Viscosupplementation Market Size Grows from US$3.4B to US$5.2B by 2033, Says Persistence Market Research

The viscosupplementation market is experiencing significant growth as it plays a pivotal role in the treatment of osteoarthritis (OA), especially in the knee joint. Viscosupplementation therapy primarily involves the injection of hyaluronic acid (HA) into the affected joint, restoring the natural lubrication and shock absorption that may be lost due to cartilage degradation. This injectable therapy aims to improve the functionality and comfort of the joint without the need for invasive surgical procedures.

The global market for viscosupplementation is poised to witness substantial growth, with projections estimating its value will increase from $3.4 billion in 2026 to $5.2 billion by 2033, growing at a compound annual growth rate (CAGR) of 6.2%. This surge can be attributed to various factors, including the rising prevalence of osteoarthritis, especially among aging populations, and the increasing demand for non-surgical, minimally invasive treatments. Additionally, the expansion of research into treating other joints such as the hip and shoulder further broadens the market's therapeutic scope. The growing acceptance of viscosupplementation therapies, particularly in outpatient settings and sports medicine, further bolsters its potential for growth.

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Key Highlights from the Report

• The global viscosupplementation market is projected to grow from $3.4 billion in 2026 to $5.2 billion by 2033.
• The rising prevalence of knee osteoarthritis and an aging population are primary drivers for market growth.
• Single-injection formulations are increasingly popular due to their convenience, improved patient compliance, and reduced procedural burden.
• Technological advancements in high-molecular-weight hyaluronic acid formulations are enhancing clinical outcomes.
• North America leads the market, driven by high disease awareness, favorable reimbursement policies, and an advanced healthcare infrastructure.
• Hospitals and orthopedic clinics remain the primary end-users, benefiting from large patient volumes and advanced injection technologies.

Market Segmentation

The viscosupplementation market is segmented based on product type, end-users, and applications, with the largest share attributed to knee osteoarthritis treatments. By product, the single-injection viscosupplementation segment dominates the market. This is due to the convenience of a single injection compared to multiple doses, which improves patient adherence and reduces the burden on healthcare systems. Single-injection treatments are particularly attractive in outpatient and ambulatory settings, where reducing the number of patient visits is a key operational goal.

In terms of end-users, hospitals and orthopedic clinics are the largest adopters of viscosupplementation therapies. These facilities benefit from greater specialist availability and advanced imaging technologies, such as ultrasound guidance, which supports accurate injection administration. With higher patient volumes and established infrastructure, hospitals and clinics are critical in ensuring widespread adoption of viscosupplementation.

The application segment is dominated by knee osteoarthritis, which remains the most common site of treatment due to the knee's role as a high-impact, weight-bearing joint. The clinical evidence supporting hyaluronic acid injections in knee OA is well-established, making it the most routine application. However, growing clinical data supporting the use of viscosupplementation for the hip, shoulder, and ankle joints is slowly expanding the market's therapeutic horizon.

Regional Insights

In terms of regional market trends, North America continues to dominate the viscosupplementation market. The U.S., in particular, leads the global market due to its large aging population, high prevalence of osteoarthritis, and well-established healthcare infrastructure. The widespread acceptance of minimally invasive treatments like viscosupplementation in North America is facilitated by strong insurance reimbursement policies, making treatments more accessible to a larger segment of the population. Furthermore, the presence of major manufacturers and continuous investments in R&D drive the adoption of advanced technologies such as ultrasound-guided injection systems, enhancing treatment precision and patient outcomes.

On the other hand, the Asia Pacific region is experiencing rapid growth due to increasing osteoarthritis cases, urbanization, and a rise in lifestyle-related joint issues. Countries like China, Japan, South Korea, and India are witnessing growing demand for non-surgical interventions like viscosupplementation as aging populations seek alternatives to surgery. Expanding healthcare access and rising disposable incomes in these countries are contributing factors to the market's expansion. Moreover, technological advancements, including ultrasound-guided injections, are improving the accuracy and effectiveness of viscosupplementation in this region, further spurring its adoption.

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Market Drivers

The primary driver of growth in the viscosupplementation market is the increasing preference for joint-preserving therapies over early surgical interventions. As the global population ages, the prevalence of osteoarthritis is rising, particularly among those aged 50 and above. Many patients in this demographic are not yet candidates for total joint replacement, leading them to seek minimally invasive treatments like viscosupplementation that can provide symptom relief while preserving joint function.

Additionally, viscosupplementation offers several advantages over surgery, including reduced recovery time, fewer complications, and the ability to delay or avoid joint replacement. The growing trend toward patient-centric care, where individuals increasingly prefer non-surgical options that allow them to maintain an active lifestyle, is another factor fueling the market's growth. Moreover, advancements in product formulations, such as cross-linked hyaluronic acid and single-injection products, have improved both patient outcomes and compliance, further driving adoption.

Market Restraints

Despite the strong demand for viscosupplementation, several challenges are hindering the market's full potential. One key restraint is the safety concerns associated with avian-derived hyaluronic acid formulations. These products are sourced from rooster combs, and while purification processes are designed to eliminate most residual proteins, trace amounts may remain. This poses a risk for patients with allergies to poultry, eggs, or feathers, leading to potential adverse reactions such as localized inflammation, joint effusion, or post-injection flare-ups.

These safety concerns have led to cautious adoption of avian-derived products in certain regions, particularly in Europe and parts of Asia, where regulatory bodies impose stricter safety and ethical standards. As a result, non-animal, bio-fermented hyaluronic acid formulations are gaining popularity, and some manufacturers are shifting focus toward these alternatives to mitigate concerns and expand market penetration.

Market Opportunities

One of the most promising opportunities in the viscosupplementation market lies in the development of smart injection systems and image-guided delivery technologies. Traditional viscosupplementation injections often rely on manual positioning, which can lead to inaccuracies, especially in complex anatomical areas like the hip or shoulder. Innovations in ultrasound-guided injections and precision delivery systems are enhancing the accuracy of these injections, resulting in better therapeutic outcomes and fewer repeat treatments.

Moreover, the integration of smart features such as real-time visualization, depth-limiting needles, and pre-calibrated injection systems are making these procedures easier for healthcare providers to perform, even in less specialized settings. These technologies can help increase the adoption of viscosupplementation therapies in outpatient clinics and ambulatory care centers, where efficiency and reproducibility are crucial. As demand for minimally invasive, precise treatments grows, these innovations present a significant growth opportunity for market players.

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Company Insights
Key Players in the Market:

• Sanofi S.A.
• Zimmer Biomet Holdings Inc.
• Bioventus LLC
• Anika Therapeutics Inc.
• Fidia Pharma USA Inc.
• Ferring B.V.
• Seikagaku Corporation
• OrthogenRx Inc.
• Medical Device Business Services, Inc. (J&J)
• AVNS
• Searchlight Pharma Inc.
• Aptissen GmbH
• Teva Pharmaceutical Industries Ltd.
• TRB Chemedica International SA
• IBSA Institut Biochimique SA

Recent Developments in the Market:

In February 2024, IBSA UK, a part of the Swiss IBSA Group, launched the SINOVIAL range in the UK, featuring advanced formulations for managing osteoarthritis. The new product incorporates a proprietary NAHYCO technology, which combines high and low molecular weight hyaluronic acid for improved joint lubrication and therapeutic performance.

In January 2024, Zimmer Biomet introduced VISCO-3, a high-molecular-weight hyaluronate therapy aimed at treating moderate knee osteoarthritis. The product demonstrated a 52% reduction in pain after 12 weeks, with sustained relief for up to six months.

Conclusion

The viscosupplementation market is set for considerable expansion, driven by factors such as the rising prevalence of osteoarthritis, an aging population, and the increasing shift towards minimally invasive treatments. Key drivers like technological advancements, the growing popularity of single-injection formulations, and a shift towards joint-preserving therapies continue to shape the market's growth trajectory. Despite challenges like safety concerns related to avian-derived products, opportunities in image-guided delivery systems and precision injection technologies are likely to unlock further market potential. With North America leading the market and the Asia Pacific region emerging as a high-growth area, viscosupplementation represents a dynamic, evolving sector within the global orthopedic landscape.

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This release was published on openPR.