Chronic Rhinosinusitis Pipeline 2025: Therapies, MOA Insights, and Key Clinical Trial Updates by DelveInsight

(Las Vegas, Nevada, United States) As per DelveInsight's assessment, globally, Chronic Rhinosinusitis pipeline constitutes 6+ key companies continuously working towards developing 6+ Chronic Rhinosinusitis treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight.

"Chronic Rhinosinusitis Pipeline Insight, 2025" report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the Chronic Rhinosinusitis Market.

The Chronic Rhinosinusitis Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.

Some of the key takeaways from the Chronic Rhinosinusitis Pipeline Report: https://www.delveinsight.com/sample-request/chronic-rhinosinusitis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=gpr
• Companies across the globe are diligently working toward developing novel Chronic Rhinosinusitis treatment therapies with a considerable amount of success over the years.
• Chronic Rhinosinusitis companies working in the treatment market are AstraZeneca, Amgen, Keymed Biosciences, GlaxoSmithKline, Genentech, Inc, Novartis, Upstream Bio Inc., Regeneron Pharma, Genrix (Shanghai) Biopharmaceutical, Guangdong Hengrui Pharmaceutical, Keymed Biosciences Co.Ltd, and others, are developing therapies for the Chronic Rhinosinusitis treatment
• Emerging Chronic Rhinosinusitis therapies in the different phases of clinical trials are- LNR 125.38, TRL1068, Brensocatib, Rimegepant, Dupilumab, LYR-210, and others are expected to have a significant impact on the Chronic Rhinosinusitis market in the coming years.
• In September 2025, The US Food and Drug Administration (FDA) has approved Insmed's Brinsupri, marking a major advancement in the treatment of non-cystic fibrosis bronchiectasis (NCFB) and a pivotal achievement for the company. As the first approved therapy in this indication, Brinsupri meets the critical unmet need to reduce exacerbations and slow NCFB progression in adults and adolescents aged 12 and older. The approval covers 10mg and 25mg tablets, without restrictions on prior pulmonary exacerbation history. For Insmed, this milestone strengthens its position in the respiratory therapy market. Additionally, Brinsupri is under investigation in early-stage trials for other conditions, including chronic rhinosinusitis without nasal polyps and hidradenitis suppurativa.
• In March 2025, UK-based pharmaceutical company GSK announced favorable results from two Phase III trials ANCHOR-1 and ANCHOR-2 evaluating depemokimab for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adults. The studies demonstrated that administering the antibody twice a year resulted in statistically significant and clinically meaningful reductions in nasal polyp size and nasal obstruction when compared to placebo.
• In March 2025, Complete findings from the successful Phase III WAYPOINT trial revealed that AstraZeneca and Amgen's TEZSPIRE® (tezepelumab-ekko) significantly lessened nasal polyp severity, reduced the need for additional surgeries, and lowered systemic corticosteroid use in individuals with chronic rhinosinusitis with nasal polyps (CRSwNP) compared to placebo. These results were published in the New England Journal of Medicine and also presented as a late-breaking oral session at the AAAAI/WAO Joint Congress in San Diego, CA.

Chronic Rhinosinusitis Overview
Chronic Rhinosinusitis (CRS) is a long-term inflammation of the nasal and sinus passages that lasts for more than 12 weeks. It is a common condition that can significantly impact a person's quality of life. CRS is characterized by inflammation of the mucous membranes lining the nose and sinuses, leading to symptoms such as nasal congestion, facial pain or pressure, and difficulty breathing through the nose.

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Emerging Chronic Rhinosinusitis Drugs Under Different Phases of Clinical Development Include:
• NUCALA (mepolizumab): GlaxoSmithKline
• TEZSPIRE (tezepelumab): AstraZeneca/Amgen
• FASENRA (benralizumab): AstraZeneca
• Tezepelumab: AstraZeneca/Amgen
• CM310: Keymed Biosciences
• GSK3511294 (depemokimab): GlaxoSmithKline
• Omalizumab: Genentech, Inc
• Xolair: Novartis
• Verekitug (UPB-101): Upstream Bio Inc.
• Dupilumab SAR231893: Regeneron Pharmaceuticals
• GR1802 injection: Genrix (Shanghai) Biopharmaceutical
• SHR-1905 Injection: Guangdong Hengrui Pharmaceutical
• CM310: Keymed Biosciences Co.Ltd

Chronic Rhinosinusitis Route of Administration
Chronic Rhinosinusitis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as
• Oral
• Parenteral
• Intravitreal
• Subretinal
• Topical
• Molecule Type

Chronic Rhinosinusitis Molecule Type
Chronic Rhinosinusitis Products have been categorized under various Molecule types, such as
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Gene therapy
• Product Type

Chronic Rhinosinusitis Pipeline Therapeutics Assessment
• Chronic Rhinosinusitis Assessment by Product Type
• Chronic Rhinosinusitis By Stage and Product Type
• Chronic Rhinosinusitis Assessment by Route of Administration
• Chronic Rhinosinusitis By Stage and Route of Administration
• Chronic Rhinosinusitis Assessment by Molecule Type
• Chronic Rhinosinusitis by Stage and Molecule Type

DelveInsight's Chronic Rhinosinusitis Report covers around 6+ products under different phases of clinical development like
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I)
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Further Chronic Rhinosinusitis product details are provided in the report. Download the Chronic Rhinosinusitis pipeline report to learn more about the emerging Chronic Rhinosinusitis therapies
https://www.delveinsight.com/sample-request/chronic-rhinosinusitis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=gpr

Some of the key companies in the Chronic Rhinosinusitis Therapeutics Market include:
Key companies developing therapies for Chronic Rhinosinusitis are - AstraZeneca, Amgen, GlaxoSmithKline, Keymed Biosciences, Biohaven Pharmaceuticals, and others.

Chronic Rhinosinusitis Pipeline Analysis:
The Chronic Rhinosinusitis pipeline report provides insights into
• The report provides detailed insights about companies that are developing therapies for the treatment of Chronic Rhinosinusitis with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Chronic Rhinosinusitis Treatment.
• Chronic Rhinosinusitis key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Chronic Rhinosinusitis Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Chronic Rhinosinusitis market.
The report is built using data and information traced from the researcher's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.

Download Sample PDF Report to know more about Chronic Rhinosinusitis drugs and therapies
https://www.delveinsight.com/sample-request/chronic-rhinosinusitis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=gpr

Chronic Rhinosinusitis Pipeline Market Drivers
• High and rising prevalence of chronic rhinosinusitis, including CRS with nasal polyps (CRSwNP), is fueling demand for novel therapies.
• Limitations of conventional treatments such as corticosteroids and surgery are driving interest in targeted biologics and advanced therapies.
• Growing understanding of underlying inflammatory pathways is supporting the development of precision and biologic treatments.
• Increasing clinical trial activity and strong pharma investment are accelerating pipeline expansion.

Chronic Rhinosinusitis Pipeline Market Barriers
• High development costs and lengthy clinical trial timelines may slow pipeline progress.
• Stringent regulatory requirements for chronic inflammatory diseases can delay approvals.
• High pricing of biologics and reimbursement challenges may restrict widespread adoption
• Disease heterogeneity and variable patient response can complicate clinical trial outcomes and market penetration.

Scope of Chronic Rhinosinusitis Pipeline Drug Insight
• Coverage: Global
• Key Chronic Rhinosinusitis Companies: AstraZeneca, Amgen, Keymed Biosciences, GlaxoSmithKline, Genentech, Inc, Novartis, Upstream Bio Inc., Regeneron Pharma, Genrix (Shanghai) Biopharmaceutical, Guangdong Hengrui Pharmaceutical, Keymed Biosciences Co.Ltd, and others
• Key Chronic Rhinosinusitis Therapies: NUCALA (mepolizumab), TEZSPIRE (tezepelumab), FASENRA (benralizumab), Tezepelumab, CM310, GSK3511294 (depemokimab), Omalizumab, Xolair, Verekitug (UPB-101), Dupilumab SAR231893, GR1802 injection, SHR-1905 Injection, CM310, and others
• Chronic Rhinosinusitis Therapeutic Assessment: Chronic Rhinosinusitis current marketed and Chronic Rhinosinusitis emerging therapies
• Chronic Rhinosinusitis Market Dynamics: Chronic Rhinosinusitis market drivers and Chronic Rhinosinusitis market barriers

Contact Us:
Gaurav Bora
gbora@delveinsight.com
+14699457679
Healthcare Consulting
https://www.delveinsight.com/consulting-services

About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate business growth and overcome challenges with a practical approach.

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