Human Liver Models Market to Reach US$ 3.76 Billion by 2033 at 12.3% CAGR, Driven by Rising Drug Discovery Needs and Shift to 3D & Organ-on-Chip Models | DataM Intelligence

According to DataM Intelligence, the global Human Liver Models market reached US$ 1.37 billion in 2024 and is expected to reach US$ 3.76 billion by 2033, growing at a CAGR of 12.3% during the forecast period 2025-2033, driven by increasing demand for accurate in vitro liver models in ADME studies, toxicology testing, and drug discovery, shift from 2D to advanced 3D and organ-on-chip systems, growing regulatory pressure to reduce animal testing, and strong adoption by pharmaceutical & biotechnology companies and academic institutes.

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Human Liver Models Market Key Mergers and Acquisitions

✦ January 2026: Emulate Inc. acquired a microfluidics technology startup to enhance its organ-on-chip liver models with improved vascularization and multi-organ integration for drug discovery.
✦ December 2025: Organovo Holdings Inc. completed a strategic acquisition of a 3D bioprinting firm to expand its bioengineered liver tissue capabilities for disease modelling and toxicology testing.
✦ November 2025: CN Bio Innovations Ltd secured a licensing agreement with an advanced liver spheroid developer to integrate next-generation 3D models into its PhysioMimics platform for ADME and hepatotoxicity studies.

Human Liver Models Market Key Industry Developments

☑️ January 2026: Corning Incorporated, Emulate Inc., and InSphero launched upgraded 3D liver models and organ-on-chip systems with enhanced hepatocyte functionality and multi-cellular complexity, gaining adoption in pharmaceutical ADME and toxicology screening.
☑️ December 2025: BioIVT LLC and MIMETAS B.V. expanded their liver model offerings with improved cryopreserved and microfluidic platforms, targeting disease modelling for NASH and fibrosis in research institutes.
☑️ November 2025: CELLINK, Visikol, Inc., and Cyprotex PLC introduced new 3D bioprinted and spheroid-based liver models with high-throughput capabilities, supporting drug discovery and safety assessment in biotech and pharma pipelines.

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Human Liver Models Market Segmentation Analysis

By Product Type: 3D Models hold the largest and fastest-growing share due to superior physiological relevance, better prediction of drug metabolism and toxicity compared to 2D cultures, and increasing use in organ-on-chip and spheroid formats; 2D Models remain significant for cost-effective initial screening and high-throughput assays.

By Application: ADME Studies and Toxicology Testing account for major demand driven by pharmaceutical need for reliable in vitro liver models to assess drug absorption, metabolism, and hepatotoxicity; Drug Discovery grows rapidly for early-stage compound screening; Disease Modelling expands for NASH, fibrosis, and rare liver disorders; Others include basic research and regenerative medicine.

By End-User: Pharmaceutical & Biotechnology Companies dominate with the highest share for drug development and safety testing; Academic & Research Institutes grow steadily for fundamental liver biology and disease modelling studies; Contract Research Organizations expand for outsourced preclinical testing services.

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Human Liver Models Market Key Players

✦ Emulate Inc. - In January 2026, acquired a microfluidics startup and launched next-generation liver-on-chip models with vascularized and multi-cellular features for improved ADME and toxicology prediction.
✦ Organovo Holdings Inc. - Completed acquisition of a 3D bioprinting firm in December 2025 and expanded bioengineered liver tissues for disease modelling and high-fidelity drug testing applications.
✦ CN Bio Innovations Ltd - Integrated advanced liver spheroid tech in November 2025 and rolled out enhanced PhysioMimics platform for hepatotoxicity and NASH modelling in pharma pipelines.
✦ InSphero - Introduced upgraded 3D liver microtissues in late 2025 with higher throughput and better metabolic function, targeting toxicology screening in biotech and CROs.
✦ MIMETAS B.V. - Expanded Organ-on-a-Chip liver models in December 2025 with improved microfluidic designs for disease modelling and drug metabolism studies in academic and pharmaceutical research.

Human Liver Models Market Regional Insights

North America commands the largest market share in the global Human Liver Models market, supported by advanced pharmaceutical R&D infrastructure, high investment in drug discovery and toxicology, strong adoption of 3D and organ-on-chip models, favorable regulatory environment for alternative testing methods, and presence of leading bioengineering companies driving innovation.

Asia-Pacific remains the fastest-growing region, fueled by rapid expansion of pharmaceutical and biotech industries in China, India, and Japan, increasing focus on in vitro models to reduce animal testing, growing academic and research capabilities, government support for advanced drug development, and aggressive adoption of 3D liver models in ADME and disease modelling.

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