How women over 40 can still become mothers today with the help of modern reproductive medicine

Madrid, January 2026. More and more women today are consciously choosing to have children later in life. However, fertility declines significantly after the age of 40, and many only realize this once valuable time has already passed. What realistic options are still available? And how can modern reproductive medicine help? Late motherhood: the biological reality after 40

"From the age of 40, on average only about one in five blastocysts is genetically intact, i.e., chromosomally healthy (euploid)," explains Dr. Katharina Spies, reproductive medicine specialist and medical director of the Vida Fertility Clinic, who has been working with patients in this age group on a daily basis for almost 15 years.

In practice, this means that even embryos with good morphological quality often have chromosomal changes that make implantation or healthy development impossible.

What is PGT-A and why is it so important after 40?

PGT-A (preimplantation genetic testing for chromosome analysis) is a genetic procedure in which embryos are examined before transfer. The aim is to select only embryos with a complete and correct set of chromosomes. This method is particularly crucial for women over 40. Without PGT-A, embryos that have no biological chance of resulting in pregnancy are often transferred.

"Without this analysis, many women experience several unsuccessful transfers in a row. This not only costs time and money, but above all emotional energy," emphasizes Dr. Spies. In Germany for instance, PGT is only permitted in very limited exceptional cases. In Spain, on the other hand, PGT-A has been an integral part of modern fertility treatment for years.

Egg donation: an established option with long experience

If the quality of your own eggs is no longer sufficient, egg donation may be another realistic option. In Germany, it is not provided for by law, whereas the donation of male gametes is permitted. Spain, on the other hand, has almost 40 years of clinical experience with egg donation. This treatment is established and accepted both medically and socially. At Vida Fertility, egg donation is treated with special respect. "Our donors are VIP patients to us," says Dr. Spies. "They enable many women to fulfill their desire to have children. For some, they are literally angels."

Act early, because every cycle counts

One crucial factor is often underestimated: time. From the age of 40, every cycle counts. Waiting months for an appointment with a non-specialist gynecologist can cost you valuable opportunities. Dr. Spies therefore recommends seeking specialized advice at an early stage. "Today, there are clinics that speak fluently many languages, understand the legal differences, and can present realistic options. Waiting doesn't help anyone at this age."

Vida Fertility
Madrid - Alicante (Spain)
contact@vidafertility.com

Vida Fertility takes a personalized approach to each patient, focusing on both medical expertise and the person behind each treatment path. Patients are welcomed into a warm and supportive environment, with the latest technology in reproductive medicine optimizing every treatment. The team ensures that patients feel heard and in safe hands, building trust and confidence throughout the process. With consistently high success rates and its own egg donors, Vida Fertility works extensively with international patients who often come to Madrid and Alicante after previous failed cycles, making the clinic a reference for complex cases. Patients receive seamless, reassuring care in their own language from the first contact to pregnancy.

This release was published on openPR.