Targeted-protein Degradation Therapeutics Market Set to Surge - Key Insights You Must Know

Targeted-protein Degradation Therapeutics Market Size

The global market for Targeted-protein Degradation Therapeutics was estimated to be worth US$ 1132 million in 2023 and is forecast to a readjusted size of US$ 1821.4 million by 2030 with a CAGR of 6.3% during the forecast period 2024-2030.

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Targeted protein degradation (TPD) has surfaced as a novel and innovative chemical tool and therapeutic modality. By co-opting protein degradation pathways, TPD facilitates complete removal of the protein molecules from within or outside the cell. While the pioneering Proteolysis-Targeting Chimera (PROTAC) technology and molecular glues hijack the ubiquitin-proteasome system, newer modalities co-opt autophagy or the endo-lysosomal pathway.

The Protein Degradation Therapy market has gained momentum as a promising approach in drug development. This innovative strategy aims to target disease-causing proteins by facilitating their degradation within cells. Proteins that contribute to diseases like cancer and neurodegenerative disorders can be selectively broken down using small molecules known as proteolysis-targeting chimeras (PROTACs) or other protein degraders. This approach offers advantages over traditional inhibition methods, potentially leading to more effective treatments with reduced side effects. As researchers delve into protein-protein interactions and cellular mechanisms, the Protein Degradation Therapy market is expanding, presenting opportunities to address previously challenging diseases and advance precision medicine. Clinical progress and continued research in this field are expected to shape the future of therapeutic interventions.

By Type
• ARV-110
• ARV-471

By Application
• Cancer
• Neuroscience

Key Companies
Arvinas, Nurix Therapeutics, Kymera Therapeutics, C4 Therapeutics

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