Non-Opioid Pain Treatment Market Set to Soar: Innovative Therapies Redefining Pain Management by 2032 | Major Companies - Aphria Inc., Aurora, Bedrocan, Cara Therapeutics.

Market Overview:

The Non-Opioid Pain Treatment Market is expected to grow at a CAGR of 8% during the forecast period (2024-2031).

The Non-Opioid Pain Treatment Market report, published by DataM Intelligence, provides in-depth insights and analysis on key market trends, growth opportunities, and emerging challenges. Committed to delivering actionable intelligence, DataM Intelligence empowers businesses to make informed decisions and stay ahead of the competition. Through a combination of qualitative and quantitative research methods, it offers comprehensive reports that help clients navigate complex market landscapes, drive strategic growth, and seize new opportunities in an ever-evolving global market.

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The Non-Opioid Pain Treatment Market encompasses therapies, medications, and interventions designed to manage acute and chronic pain without using opioids. It includes non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen, anticonvulsants, antidepressants, biologics, and non-pharmacological approaches like physical therapy, acupuncture, and neuromodulation. This market addresses growing concerns over opioid addiction and aims to provide safer, effective pain management solutions globally.

Recent Key Developments of United States:

✅ November 2025: Novaremed completed all patient visits in its NIH-funded Phase 2b trial of nispomeben (NRD.E1) for chronic pain in diabetic peripheral neuropathy, with topline results expected soon. The 12-week placebo-controlled study enrolled 127 patients and builds on prior Phase 2a data showing pain reduction. Nispomeben acts via a novel mechanism without binding opioid receptors.

✅ October 2025: FDA issued updated draft guidance on non-opioid analgesics for chronic pain as part of its opioid crisis strategy. It emphasizes efficient trial designs, patient-reported outcomes, and expedited programs to accelerate safe alternatives. About 1 in 5 U.S. adults with chronic pain still receive opioids, highlighting the need.

✅ September 2025: FDA released draft guidance titled "Development of Non-Opioid Analgesics for Chronic Pain" to assist sponsors in developing non-opioid treatments, focusing on phase 3 trial designs, safety, efficacy, and reducing opioid use. This fulfills a mandate from the SUPPORT Act and accepts comments for 60 days. The guidance promotes regulatory flexibility, such as fewer trials in certain cases.​​​

Recent Key Developments of Europe:

✅ November 2025: Tonix Pharmaceuticals announced a presentation at BIO-Europe 2025 on TONMYA for fibromyalgia treatment in adults, highlighting non-opioid progress. The event focuses on industry partnerships for pain innovations. This reflects ongoing clinical momentum in Europe.

✅ October 2025: PharmNovo announced plans for IND submission by end-2025 and Phase IIa trial application in Europe (Spain, Poland, Czech Republic) for PN6047, a novel chronic pain treatment. Levicept presented data suggesting LEVI-04, a neurotrophin-3 inhibitor, may modify osteoarthritis disease and improve symptoms. These advances target unmet needs in non-opioid therapies.

✅ September 2025: A trial found an experimental cannabis extract reduced chronic lower back pain in 820 adults unresponsive to standard non-opioid medicines. This supports non-opioid options amid growing interest in cannabis-based therapies. The study underscores potential for chronic pain management without opioids.

List of the Key Players in the Non-Opioid Pain Treatment Market:

Aphria Inc.
Aurora
Bedrocan
Canopy Growth Corp.
Cara Therapeutics
Centrexion Therapeutics
Cronos Group
GW Pharmaceuticals
Medical Marijuana Inc.
Medropharm Gmbh
Panag Pharma Inc.
Tilray
US Worldmeds LLC
Vanway

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This Report Covers:

✔ Go-to-market Strategy.

✔ Neutral perspective on the market performance.

✔Development trends, competitive landscape analysis, supply side analysis, demand side analysis, year-on-year growth, competitive benchmarking, vendor identification, and other significant analysis, as well as development status.

✔Customized regional/country reports as per request and country level analysis.

✔ Potential & niche segments and regions exhibiting promising growth covered.

✔ Analysis of Market Size (historical and forecast), Total Addressable Market (TAM), Serviceable Available Market (SAM), Serviceable Obtainable Market (SOM), Market Growth, Technological Trends, Market Share, Market Dynamics, Competitive Landscape and Major Players (Innovators, Start-ups, Laggard, and Pioneer).

Segments Covered in the Non-Opioid Pain Treatment Market: CCC

Regional Analysis:

⇥ North America (U.S., Canada, Mexico)

⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)

⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)

⇥ South America (Colombia, Brazil, Argentina, Rest of South America)

⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)

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Chapter Outline

⏩ Market Overview: It contains five chapters, as well as information about the research scope, major manufacturers covered, market segments, Non-Opioid Pain Treatment market segments, study objectives, and years considered.

⏩ Market Landscape: The competition in the Global Non-Opioid Pain Treatment Market is evaluated here in terms of value, turnover, revenues, and market share by organization, as well as market rate, competitive landscape, and recent developments, transaction, growth, sale, and market shares of top companies.

⏩ Companies Profiles: The Global Non-Opioid Pain Treatment market's leading players are studied based on sales, main products, gross profit margin, revenue, price, and growth production.

⏩ Market Outlook by Region: The report goes through gross margin, sales, income, supply, market share, CAGR, and market size by region in this segment. North America, Europe, Asia Pacific, Middle East & Africa, and South America are among the regions and countries studied in depth in this study.

⏩ Market Segments: It contains the deep research study which interprets how different end-user/application/type segments contribute to the Non-Opioid Pain Treatment Market.

⏩ Market Forecast: Production Side: In this part of the report, the authors have focused on production and production value forecast, key producers forecast, and production and production value forecast by type.

⏩ Research Findings: This section of the report showcases the findings and analysis of the report.

⏩ Conclusion: This portion of the report is the last section of the report where the conclusion of the research study is provided.

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People Also Ask:

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