Japan's Chronic Inflammatory Demyelinating Polyneuropathy Market Accelerates with Rising Diagnosis Awareness and Advancements in Immunotherapy Solutions| DataM Intelligence

The global Chronic inflammatory demyelinating polyneuropathy market size reached US$ 2.02 Billion in 2024 and is expected to reach US$ 5.07 Billion by 2033, growing at a CAGR of 9.7% during the forecast period 2025-2033.

The chronic inflammatory demyelinating polyneuropathy market is driven by a rapidly aging population with higher neuropathy prevalence, improved diagnostic capabilities, expanding access to immunoglobulin and biologic therapies, supportive reimbursement and rare-disease policies, increasing specialist neuromuscular centers, and active clinical research collaborations that accelerate treatment adoption and long-term disease management nationwide.

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Japan: Key Industry Developments
1. VYVDURA - expanded CIDP approval & treatment access in Japan
VYVDURA (efgartigimod alfa and hyaluronidase‐qvfc), marketed in Japan as, has been approved for adult CIDP treatment, representing one of the first innovative FcRn‐blocking therapies in the Japanese CIDP landscape and providing a weekly subcutaneous administration option. Approval and clinical use commenced following regulatory action in previous years, and in 2025 the dosing period restriction was formally removed, easing long‐term treatment flexibility for CIDP patients.

2. Riliprubart - orphan drug designation for CIDP in Japan (development stage)
In June 2025, the Japanese Ministry of Health, Labour and Welfare granted orphan drug designation to riliprubart (SAR445088), a monoclonal antibody targeting activated C1s in the complement pathway, for the treatment of CIDP. This designation supports ongoing Phase 3 clinical trials and underscores progress toward a potential first‐in‐class complement‐targeted therapy in Japan.

Market Segmentation Analysis:

Segmentation by treatment type highlights the diversity of therapeutic approaches utilized in Japan's CIDP market. Conventional therapies such as intravenous immunoglobulin (IVIG), corticosteroids, and plasmapheresis remain foundational, with IVIG therapies widely adopted due to their clinical effectiveness and suitability as first‐line options. Other segments include emerging immunotherapies and supportive care like physiotherapy, reflecting a shift toward personalized and multimodal treatment regimens in response to varied patient needs.

From a diagnostic standpoint, the market segmentation covers multiple diagnostic tools that inform treatment decisions, including electrodiagnostic testing, EMG, cerebrospinal fluid analysis, and laboratory panels. This diagnostic segmentation underscores Japan's emphasis on precise subtype differentiation-between typical and atypical CIDP variants-as part of efforts to optimize therapeutic outcomes.

Route of administration is another important segment in the Japanese market, with injectable and intravenous forms dominating, given the nature of most approved CIDP therapies (e.g., IVIG and biologics). Emerging subcutaneous formulations are also gaining interest for convenience and potential home‐based administration models.

In terms of end‐user segmentation, hospitals and specialty neurology clinics represent the primary revenue sources due to centralized treatment delivery, comprehensive care infrastructure, and reimbursement frameworks that support complex CIDP care. Pharmacies and outpatient clinics further contribute to distribution and patient access segments, particularly as treatment paradigms evolve.

Key Players:
Bio Products Laboratory Ltd, Momenta Pharmaceuticals, Grifols, Baxter, Kedrion S.p.A, Octapharma, Shire, Mitsubishi Tanabe Pharma Corporation,CSL Behring, Teijin Pharma Limited and Pfizer, Inc.

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Growth Drivers:
Rising Aging Population: Japan has a high elderly population, increasing CIDP prevalence.
Improved Diagnosis: Advanced diagnostic tools and greater physician awareness support early detection.
Growing Healthcare Spending: Government initiatives and insurance coverage improve patient access to treatment.
Advancements in Therapies: Introduction of new immunotherapies and biologics fuels market growth.
Patient Awareness Programs: Campaigns and advocacy groups enhance recognition and treatment uptake.
Supportive Regulatory Environment: Streamlined approval pathways for innovative therapies encourage market expansion.

Regional Market Dynamics -
North America - 40% Share
North America leads with 40%, driven by high awareness of autoimmune disorders, established healthcare infrastructure, early adoption of advanced therapies, and strong R&D investment in neurological treatments.

Europe - 28% Share
Europe holds 28%, supported by well-established healthcare systems, rising prevalence of CIDP, favorable reimbursement policies, and ongoing clinical trials in Germany, France, the U.K., and Italy.

Asia-Pacific - 22% Share
Asia-Pacific accounts for 22%, fueled by growing awareness, increasing diagnosis rates, improving healthcare access, and government initiatives in Japan, China, India, and South Korea to support neurological care.

South America - 5% Share
South America holds 5%, supported by gradual awareness of CIDP, improving healthcare facilities, and limited availability of advanced therapies in Brazil, Argentina, and neighboring countries.

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