Press release
Allogeneic Stem Cell Transplantation Market End User Insights Hospitals Research Institutes and Clinics
InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the "Global Allogeneic Stem Cell Transplantation Market - (By Source (Bone Marrow, Peripheral Blood, Umbilical Cord Blood, Adipose Tissue, Dental Pulp, and Others), By Application (Cancer, Autoimmune Diseases, Blood Disorders, Cardiac Disorders, Neurological Disorders, Diabetes, and Others), By End User (Hospitals, Research Institutes, Specialty Clinics, and Others), By Cell Type (Allogeneic MSCs, Allogeneic HSCs, and Others)), Trends, Industry Competition Analysis, Revenue and Forecast To 2031."According to the latest research by InsightAce Analytic, the Global Allogeneic Stem Cell Transplantation Market is valued at US$ 3.66 Bn in 2022, and it is expected to reach US$ 6.75 Bn by 2031, with a CAGR of 7.21% during the forecast period of 2023-2031.
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Allogeneic stem cell transplantation entails the transfer of healthy hematopoietic stem cells from a genetically non-identical, human leukocyte antigen (HLA)-matched donor-either related or unrelated-to a recipient. This therapeutic approach has gained significant traction in the treatment of a wide range of medical conditions. The global allogeneic stem cell transplantation market is experiencing robust growth, driven by advancements in genetic research and the expanding application of stem cell therapies across diagnostic and therapeutic domains.
The rising global prevalence of chronic diseases, including cancer, autoimmune disorders, and cardiovascular conditions, is a key factor supporting market expansion. Hematologic malignancies, such as leukemia, multiple myeloma, and lymphoma, have shown a notable increase over the past decade. For patients with high-risk or treatment-resistant forms of these diseases, allogeneic hematopoietic stem cell transplantation offers a potentially curative treatment option.
According to the World Health Organization, cancer remains a leading cause of mortality worldwide, accounting for approximately ten million deaths annually. This escalating disease burden, coupled with the urgent need for more effective therapeutic alternatives, is expected to drive further demand for allogeneic stem cell therapies.
Despite its therapeutic promise, allogeneic transplantation faces significant challenges. Immunologic complications present major barriers to successful outcomes, as the recipient's immune system may recognize donor cells as foreign, even under immunosuppressive conditions, leading to engraftment failure. Additionally, the risk of graft-versus-host disease (GVHD)-in which donor lymphocytes attack the recipient's healthy tissues-remains a critical concern, potentially resulting in severe morbidity and mortality. These challenges highlight the ongoing need for innovations in immunosuppressive protocols and post-transplant care to enhance safety and efficacy.
List Of Prominent Players In The Allogeneic Stem Cell Transplantation Market:
• Celgene Corporation
• Mesoblast Ltd.
• Pluristem Therapeutics Inc.
• MEDIPOST Co., Ltd.
• Takeda Pharmaceutical Company Limited
• Astellas Pharma Inc.
• Cellular Biomedicine Group, Inc.
• Biosolution Co., Ltd.
• StemCell Technologies Inc.
• Caladrius Biosciences, Inc.
• TiGenix N.V.
• ViaCord
• Vericel Corporation
• Regen Biopharma Inc.
• Gamida Cell Ltd.
• Histogenics Corporation
• BrainStorm Cell Therapeutics Inc.
• Lineage Cell Therapeutics, Inc.
• Bluebird Bio
• Sanofi
• Talaris Therapeutics.
• Others
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Market Dynamics
Drivers:
The increasing demand for allogeneic stem cell transplantation is largely driven by the therapeutic potential of mesenchymal stem cells (MSCs) sourced from mature tissues, including bone marrow, adipose tissue, and connective tissues. MSCs possess significant immunomodulatory properties, expanding their applicability beyond traditional hematopoietic treatments.
Allogeneic MSC-based therapies are gaining prominence within the regenerative medicine sector, owing to their potential in addressing a wide range of non-hematological conditions. Market participants are investing heavily in research, development, and commercialization initiatives aimed at broadening the use of allogeneic MSC therapies across multiple therapeutic areas, positioning the market for sustained growth and diversification.
Challenges:
Despite these opportunities, the market faces notable challenges. High treatment costs, driven by the requirement for advanced infrastructure, sophisticated manufacturing protocols, stringent quality control measures, and specialized personnel, remain a significant barrier. Additionally, the logistical complexities associated with the storage, preservation, and transport of allogeneic stem cells further increase operational expenditures.
Limited insurance reimbursement and variable healthcare coverage across regions restrict patient access, while disruptions caused by the COVID-19 pandemic-such as supply chain interruptions and strain on healthcare delivery systems-have exacerbated these issues, particularly in emerging economies. Nevertheless, as healthcare systems stabilize and restrictions ease, accessibility to allogeneic stem cell treatments is improving, supporting a rebound in procedure volumes.
Regional Trends:
North America currently leads the global allogeneic stem cell transplantation market in terms of revenue and is expected to sustain a high compound annual growth rate (CAGR) throughout the forecast period. This leadership is underpinned by advanced healthcare infrastructure, the presence of specialized transplant and oncology centers, and a robust foundation in clinical research and technological innovation.
Europe is also demonstrating significant market momentum, driven by the prevalence of both hematologic malignancies and non-malignant disorders, including myeloid and lymphoid cancers, solid tumors, and rare diseases. The increasing adoption of both allogeneic and autologous stem cell therapies in developed European nations further contributes to the region's growth trajectory.
Recent Developments:
• In September 2023, Mesoblast collaborated with the Blood & Marrow Transplant Clinical Trials Network (BMT CTN) to conduct a clinical trial examining the effectiveness of its drug, Ryoncil (remestemcel-L), in treating steroid-refractory acute graft versus host disease (SR-aGvHD). BMT CTN will undertake the trial to assess the efficacy of Ryoncil in patients aged 12 and above who have shown inadequate response to prior treatments such as corticosteroids and a second-line drug like ruxolitinib.
• In Jan 2020, Astellas and Adaptimmune formed a partnership to collaborate on the development and marketing of stem-cell derived allogeneic CAR-T and TCR T-cell treatments. The cooperation utilized Adaptimmune's ability in identifying and confirming targets to create T-cell Receptors (TCRs), chimeric antigen receptors (CARs), and HLA-independent TCRs that could recognize surface epitopes regardless of the HLA profile of the tumor cell.
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Segmentation of Allogeneic Stem Cell Transplantation Market-
By Source
• Bone Marrow
• Peripheral Blood
• Umbilical Cord Blood
• Adipose Tissue
• Dental Pulp
• Others
By Cell Type
• Allogeneic MSCs (Allogenic Mesenchymal stem cells)
• Allogeneic HSCs (Allogeneic hematopoietic stem cells)
• Others
By Application
• Cancer
• Autoimmune Diseases
• Blood Disorders
• Cardiac Disorders
• Neurological Disorders
• Diabetes
• Others
By End User
• Hospitals
• Research Institutes
• Specialty Clinics
• Others
By Region-
North America-
• The US
• Canada
• Mexico
Europe-
• Germany
• The UK
• France
• Italy
• Spain
• Rest of Europe
Asia-Pacific-
• China
• Japan
• India
• South Korea
• South East Asia
• Rest of Asia Pacific
Latin America-
• Brazil
• Argentina
• Rest of Latin America
Middle East & Africa-
• GCC Countries
• South Africa
• Rest of the Middle East and Africa
Read Overview Report- https://www.insightaceanalytic.com/report/allogeneic-stem-cell-transplantation-market/2241
About Us:
InsightAce Analytic is a market research and consulting firm that enables clients to make strategic decisions. Our qualitative and quantitative market intelligence solutions inform the need for market and competitive intelligence to expand businesses. We help clients gain competitive advantage by identifying untapped markets, exploring new and competing technologies, segmenting potential markets and repositioning products. Our expertise is in providing syndicated and custom market intelligence reports with an in-depth analysis with key market insights in a timely and cost-effective manner.
Contact us:
InsightAce Analytic Pvt. Ltd.
Visit: https://www.insightaceanalytic.com/
Tel : +1 607 400-7072
Asia: +91 79 72967118
info@insightaceanalytic.com
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