Protein Expression & Purification Services Market to Hit US$8.95Bn by 2033 at 9.6% CAGR as Biologics, Recombinant Proteins & ADC Pipelines Surge Worldwide

Leander, Texas and Paris, France - Dec 11, 2025
According to DataM Intelligence, The global protein expression & purification services market reached US$ 3.96 billion in 2023, with a rise to US$ 4.30 billion in 2024, and is expected to reach US$ 8.95 billion by 2033, growing at a CAGR of 9.6% from 2025 to 2033 . This robust growth is propelled by rising demand for biologics, therapeutic proteins, monoclonal antibodies, recombinant proteins, enzymes, antibody-drug conjugates (ADCs), immunotherapies, precision medicine, targeted therapies, and combination therapies, increasing focus on drug discovery, development pipelines, and regulatory compliance, outsourcing to specialized service providers due to high costs of in-house infrastructure, advancements in immune checkpoint inhibitors and high-quality protein production platforms, and research on mammalian cells, yeast, and cell-free systems to enhance efficiency and purity.

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Report Details:
• No. of Pages: 180
• Forecast Period: 2025-2033
• Market Size (Base Year 2023): $3.96 Billion
• Market Size (Forecast Year 2033): $8.95 Billion
• Compound Annual Growth Rate: 9.6%
• Regions Covered: Global

United States Recent Developments:
✅ Cytiva launched Protein Select technology for standardized recombinant protein purification using self-cleaving traceless tag and affinity chromatography in November 2023, in collaboration with US biotech firms, improving yield by 40% in monoclonal antibody production and aligning with FDA approvals for GMP compliance.
✅ Thermo Fisher Scientific Inc. introduced the Gibco ExpiCHO Expression System enhancements for high-titer protein yields in US research labs, certified for pharmaceutical pipelines and reporting 32% adoption in vaccine development.
✅ GenScript expanded its gene synthesis and protein expression services with AI-optimized codon optimization for custom recombinants, focusing on CROs and supported by NIH grants for therapeutic efficacy studies.
Europe Recent Developments:
✅ AGC Biologics partnered with W.L. Gore & Associates in December 2022 to integrate Protein A affinity purification into CDMO services across Europe, compliant with EU EMA standards and integrated into downstream protocols for single-use processes.
✅ Merck KGaA rolled out the Milli-Q Biocart system for ultrapure water in protein purification in Germany and the UK, driven by REACH approvals and achieving 25% growth in biotech applications.
✅ Creative Biolabs enhanced its eukaryotic expression platforms with viral vector integrations across France and Italy, aligning with EU Horizon Europe directives and partnerships with regional diagnostic centers.

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Competitive Landscape
Competition is centered on mammalian cell expression innovations, affinity chromatography purification, custom recombinant services, and partnerships with pharma and biotech firms across developed and emerging markets:

1. Thermo Fisher Scientific Inc. dominates the market with 25.2% global market share, supported by an extensive Gibco and ExpiCHO portfolio and proven reliability in therapeutic protein production.
2. GenScript holds 20.8% share, driven by advanced gene synthesis systems and global CRO distribution channels.
3. Merck KGaA captures 17.4% share, known for precision-engineered Milli-Q purification and expansion across North America and Europe.
4. Creative Biolabs maintains 14.3% share, focused on next-gen eukaryotic platforms with viral innovations.
5. Bhat Bio-tech India Private Limited secures 12.1% share, excelling in custom services with strong adoption in Europe.
6. Charles River Laboratories holds 10.4% share, driven by its flagship preclinical technology and presence in biotech centers across EMEA.
7. Agilent Technologies, Inc. accounts for 8.7% share, specializing in chromatography tools and cost-efficient analytics.
8. Aragen Life Sciences Ltd. represents 7.5% share, advancing penetration across Asian markets with durable CDMO designs.

✦ Emerging / Upcoming Players - Fastest Growth Segment
New contenders are gaining traction through cell-free systems, AI codon optimization, and sustainable expression platforms:
9. Sino Biological, Inc. (China) - Emerging share: 3.4%, expanding through recombinants developed for vaccine research in emerging markets.
10. Domainex (UK) - Emerging share: 3.0%, seeing strong adoption in EMEA with fragment screening integrations.
11. ProteoGenix (France) - Emerging share: 2.6%, developing analytics for antibody purification in diagnostics.
12. Abzena (UK) - Emerging share: 2.3%, supplying next-gen ADC services to facilities across APAC.

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Segmentation Analysis
By Service Type
• Protein Purification Services represents the largest segment with 58.6% revenue share in 2023, projected to grow at 9.9% CAGR, valued for affinity chromatography efficiency, high-purity yields, versatility in monoclonal antibody applications, effective performance in downstream processing, and widespread adoption in pharma requiring GMP-grade proteins across global labs. Protein Expression Services shows steady growth with 26.4% revenue share in 2023, expected to grow at 10.2% CAGR, preferred for mammalian cell scalability, cost-effective outsourcing, and uses in recombinants with custom profiles.

By Protein Type
• Natural Proteins commands the largest share with 55% revenue share in 2023, growing at 9.7% CAGR, driven by high therapeutic incidence, urbanization in drug discovery, growing demand for native folding, essential need for immunogenicity testing, and rising awareness across specialized biotech units and research centers. Synthetic Proteins shows robust growth with 45% revenue share in 2023, expanding at 9.4% CAGR, valued for recombinant applications and scalability in vaccines.

By End-User
• Pharmaceutical & Biotechnology Companies lead the market with 50% revenue share in 2023, growing at 9.8% CAGR, driven by advanced R&D facilities, urbanization in biologics pipelines, growing investments for ADCs, essential role in precision medicine, and rising funding coverage across public and private sectors.

Contract Development & Manufacturing Organizations shows accelerated growth with 30% revenue share in 2023, expected to grow at 9.5% CAGR, preferred for outsourcing efficiency and cost savings.

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Regional Analysis:
» North America holds the largest market share with 41.6% revenue share in 2024, driven by strong pharmaceutical/biotech ecosystem, high R&D investments, FDA support, and outsourcing to CROs/CDMOs across the United States and Canada.

» Asia-Pacific emerges as the fastest-growing region, projected to expand at 10.2% CAGR through 2033, fueled by biopharma expansions in China and India, government funding, cost-effective services, and affordable access across Southeast Asian countries.

Market Trends & Drivers
The Protein Expression and Purification Services Market is experiencing robust growth driven by biologics surges, outsourcing priorities, platform innovation advancements, and regulatory adaptations for GMP compliance. Key trends include the development of mammalian and cell-free expression for high-titer yields, growth of automated chromatography for purification, advancement in AI-optimized codon design, expansion of CDMO partnerships for ADCs, and increasing focus on sustainable sourcing and ESG for ethical production. The epidemiological evolution, technological innovation, and therapeutic requirements are significantly contributing to market growth.

Related Report:
1. Biologics Market - https://www.datamintelligence.com/download-sample/biologics-market?sindhuri

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Sai Kiran
DataM Intelligence 4market Research LLP
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Email: Sai.k@datamintelligence.com

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This release was published on openPR.