Press release
Postoperative Acute Pain Market is projected to reach USD 18.92 billion by 2034
Postoperative Acute Pain
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Postoperative acute pain occurs in the hours to days following surgery and varies depending on procedure type, surgical technique, and patient comorbidities. Effective post-surgical pain control is essential to enhance recovery, reduce complications, shorten hospital stays, and support early mobilization - all core components of Enhanced Recovery After Surgery (ERAS) protocols.
Key Market Highlights
• 2024 Market Size: USD 12.84 billion
• 2034 Forecast: USD 18.92 billion
• CAGR (2025-2034): 4.0%
• Largest Segment: Non-opioid analgesics
• Fastest-Growing Segment: Long-acting local anesthetics & novel non-opioid injectables
Epidemiology & Clinical Insights
1. Rising Surgical Volumes
Over 330 million surgeries are performed globally each year, including:
• Orthopedic
• General surgery
• Cardiothoracic
• Obstetrics & gynecology
• Gastrointestinal
• Neurosurgery
More surgeries = higher demand for post-operative analgesics.
2. Pain Severity & Duration
• Acute pain typically lasts hours to 72 hours post-surgery
• Up to 80% of patients experience moderate to severe pain
• Poorly managed postoperative pain increases risk of chronic pain development
3. ERAS Influence
Enhanced Recovery After Surgery guidelines strongly encourage:
• Multimodal analgesia
• Opioid sparing
• Early mobilization
Market Growth Drivers
1. Shift Toward Opioid-Sparing Protocols
Regulatory pressure and safety concerns drive adoption of:
• NSAIDs
• Acetaminophen
• COX-2 inhibitors
• Long-acting local anesthetics
2. Innovation in Local & Regional Anesthesia
Advancements include:
• Liposomal bupivacaine
• Extended-release nerve block formulations
• Continuous nerve catheters
These enable prolonged pain relief without systemic opioid use.
3. Growth of Outpatient & Same-Day Surgery
Ambulatory surgery centers rely heavily on fast-acting, safe analgesics.
4. Increasing Use of Multimodal Analgesia
Combining different drug classes improves pain control and reduces opioid doses.
5. Rising Geriatric Surgical Population
Older adults often require orthopedic, cardiac, and abdominal surgeries.
Market Restraints
• Adverse effects of opioid and non-opioid analgesics
• Reimbursement constraints for newer injectables
• Variability in ERAS adoption across regions
• Risks of chronic opioid use after surgery
Market Opportunities
1. Novel Non-Opioid Injectables
TRPV1 modulators, NOP receptor agonists, and sodium-channel blockers.
2. Extended-Release Local Anesthetics
Longer-duration pain relief reduces need for opioids and inpatient monitoring.
3. AI-Driven Personalized Pain Management
Predicts pain scores and tailors drug selection.
4. Digital Health & Wearable Monitoring
Post-surgery pain monitoring at home.
5. Robotic & Minimally Invasive Surgery
Reduces overall pain but increases demand for optimized fast-recovery analgesics.
Segmentation Overview
By Drug Class
• Non-opioids: NSAIDs, acetaminophen, COX-2 inhibitors
• Opioids: morphine, hydromorphone, fentanyl
• Local anesthetics: bupivacaine, ropivacaine, lidocaine
• Combination analgesics
• Emerging therapies
By Route of Administration
• Oral
• IV
• Intramuscular
• Epidural
• Peripheral nerve block
• Topical / transdermal
By Surgery Type
• Orthopedic
• General surgery
• Cardiovascular
• Obstetrics & gynecology
• Gastrointestinal
• Urologic
• Others
By End User
• Hospitals
• Ambulatory surgery centers
• Specialty surgical clinics
• Retail & online pharmacies
Explore Full Report here: https://exactitudeconsultancy.com/reports/70919/postoperative-acute-pain-market
Regional Insights
North America - Largest Market
High surgical volumes, strong ERAS adoption, and rapid uptake of long-acting anesthetics.
Europe - Strong Multimodal Analgesia Adoption
Germany, UK, France, Italy, and Spain lead usage of NSAIDs and combination therapy.
Asia Pacific - Fastest Growing
Expanding healthcare access, increased elective surgeries, and rising pharmaceutical investment.
Latin America - Developing
Growth driven by improving surgical infrastructure in Brazil, Mexico, and Argentina.
Middle East & Africa - Emerging
Increasing government investment in surgical care and postoperative recovery.
Competitive Landscape
Major companies in the postoperative acute pain market include:
• Pfizer
• Johnson & Johnson
• Teva Pharmaceuticals
• Eli Lilly
• Grunenthal
• Pacira BioSciences (liposomal bupivacaine)
• Fresenius Kabi
• Mylan / Viatris
• Bayer
• Novartis
R&D focuses on opioid-sparing analgesics, sustained-release anesthetics, and multimodal pain therapy optimization.
Recent Market Developments
• Growing global adoption of liposomal bupivacaine in orthopedic and soft-tissue surgeries
• FDA approvals for new non-opioid injectable pain medications
• Integration of nerve-block technologies in ERAS pathways
• AI-driven postoperative pain prediction models in pilot use
• Launch of fast-acting intranasal analgesics for ER settings
Future Outlook (2025-2034)
The Postoperative Acute Pain Market will expand as:
• Non-opioid and multimodal analgesia becomes the global standard of care
• Advanced local anesthetic delivery reduces opioid dependence
• Minimally invasive surgery increases demand for rapid-recovery pain control
• Technological innovations improve personalization and monitoring
By 2034, the market is expected to reach USD 18.92 billion, driven by global surgical volume growth and continuous innovation in postoperative pain management.
This report is also available in the following languages : Japanese (術後急性疼痛), Korean (수술 후 급성 통증), Chinese (术后急性疼痛), French (Douleur aiguë postopératoire), German (Postoperativer akuter Schmerz), and Italian (Dolore acuto postoperatorio), etc.
Request for a sample of this research report at (Use Corporate Mail ID for Quick Response) @ https://exactitudeconsultancy.com/request-sample/70919
Our More Reports:
Moderate To Severe Acute Pain Market
https://exactitudeconsultancy.com/reports/70916/moderate-to-severe-acute-pain-market
Non-Postoperative Acute Pain Market
https://exactitudeconsultancy.com/reports/70917/non-postoperative-acute-pain-market
Acute Pain Market
https://exactitudeconsultancy.com/reports/70981/acute-pain-market
Lumbosacral Radicular Pain Market
https://exactitudeconsultancy.com/reports/71947/lumbosacral-radicular-pain-market
About Us
Exactitude Consultancy is a market research & consulting services firm which helps its client to address their most pressing strategic and business challenges. Our market research helps clients to address critical business challenges and also helps make optimized business decisions with our fact-based research insights, market intelligence, and accurate data.
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