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Moderate to Severe Plaque Psoriasis Market is expected to reach USD 43-48 billion by 2032, registering a strong CAGR of 6%-7%
Market OverviewThe Moderate to Severe Plaque Psoriasis market continues to grow robustly, supported by rapid adoption of biologics, targeted oral therapies, and personalized treatment pathways. Psoriasis is a chronic immune-mediated inflammatory disease, and moderate to severe cases typically require systemic therapy due to the extent of skin involvement and impact on quality of life.
The global market for moderate to severe plaque psoriasis was valued at USD 27-30 billion in 2024. With expanding biologic portfolios, next-generation oral drugs, and rising treatment penetration in emerging markets, the market is expected to reach USD 43-48 billion by 2032, registering a strong CAGR of 6%-7%.
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Market Drivers
• High global disease burden, with increasing diagnosis and specialist consultations.
• Strong uptake of biologics, including TNF inhibitors, IL-17 inhibitors, and IL-23 inhibitors.
• Introduction of newer targeted therapies, such as TYK2 inhibitors and advanced JAK modulators.
• Rising demand for long-term disease control and remission, improving patient adherence to systemic therapies.
• Growing awareness of psoriasis as a systemic inflammatory disease, associated with cardiovascular and metabolic risks.
Key Challenges
• High cost of biologics, limiting access in lower-income regions.
• Need for long-term safety monitoring, especially for immunomodulators.
• Insurance and reimbursement barriers, particularly for newer therapies.
• Variable treatment response, requiring individualized therapeutic approaches.
• Stigma and psychological impact, affecting timely treatment seeking.
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Market Trends
• Shift toward IL-23 and IL-17 biologics, which offer superior efficacy and durable remission.
• Growing adoption of TYK2 inhibitors, providing a convenient oral option with targeted action.
• Increasing availability of biosimilars, improving affordability and market reach.
• Use of digital monitoring tools, enabling improved disease tracking and therapy optimization.
• Development of combination and step-up therapy models, enhancing long-term outcomes.
Segment Overview
• By Treatment: Biologics (TNF, IL-17, IL-23 inhibitors), oral systemic therapies (TYK2, JAK inhibitors), traditional systemic agents (methotrexate, cyclosporine), phototherapy (adjunct).
• By Severity: Moderate psoriasis, severe psoriasis.
• By End User: Hospitals, dermatology centers, specialty clinics, home-based digital therapy programs.
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Regional Insights
• North America dominates due to high biologic adoption, strong reimbursement frameworks, and advanced dermatology networks.
• Europe follows with widespread use of IL-17/IL-23 inhibitors and supportive healthcare policies.
• Asia-Pacific is the fastest-growing region, driven by expanding access to biologics, improving dermatology infrastructure, and rising disease awareness.
• Latin America & Middle East/Africa show steady growth but face cost and availability barriers to advanced therapies.
Future Outlook
The Moderate to Severe Plaque Psoriasis market is projected to expand at a CAGR of 6%-7%, supported by strong innovation in biologics, rising availability of biosimilars, and continued development of targeted oral agents. Over the next decade, treatment paradigms will evolve toward precision-guided biologic therapies, broader biosimilar adoption, and hybrid digital care models, significantly improving long-term disease control and patient quality of life.
This report is also available in the following languages : Japanese (中等度から重度の尋常性乾癬市場), Korean (중등도에서 중증의 플라크 건선 시장), Chinese (中重度斑块状银屑病市场), French (Marché du psoriasis en plaques modéré à sévère), German (Markt für mittelschwere bis schwere Plaque-Psoriasis), and Italian (Mercato della psoriasi a placche da moderata a grave), etc.
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