Isovaleric Acidemia Market to Reach USD 38.6 Million by 2034

Pune, India - December 2025 - The global Isovaleric Acidemia Market, valued at USD 19.4 million in 2024, is projected to reach USD 38.6 million by 2034, growing at a 7.1% CAGR (2025-2034), according to Exactitude Consultancy. Increased awareness of rare metabolic disorders, expansion of newborn screening programs, and improvements in long-term nutritional and pharmacological management are accelerating market demand.

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Market Summary
The Isovaleric Acidemia Market is expanding as healthcare systems enhance the diagnosis and treatment of organic acidemias. Isovaleric acidemia (IVA), caused by a deficiency of the enzyme isovaleryl-CoA dehydrogenase, leads to harmful accumulation of isovaleric acid in the body.

Management typically includes dietary protein control, glycine supplementation, carnitine therapy, and emergency management during metabolic crises. Increasing adoption of expanded newborn screening, availability of specialized medical foods, advancements in metabolic monitoring, and the emergence of gene therapy research are contributing to improved patient outcomes. North America remains the leading market, while Europe and Asia-Pacific show rising adoption of screening and treatment protocols.

Key Takeaways
• 2024 Market Size: USD 19.4 Million
• 2034 Forecast: USD 38.6 Million
• CAGR: 7.1% (2025-2034)
• Rising adoption of newborn screening tests globally
• Nutritional therapies & metabolic management remain mainstay treatments
• Asia-Pacific seeing rapid uptake due to improved pediatric healthcare

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Market Drivers
• Expansion of newborn screening for organic acidemias
• Growing awareness of rare metabolic disease management
• Improvements in emergency care protocols for metabolic crises
• Increasing use of glycine, carnitine & specialized dietary formulas
• Early-stage gene therapy research boosting long-term optimism

Segmentation Snapshot
By Treatment Type
• Nutritional Management & Medical Foods
• Glycine Supplementation
• L-Carnitine Therapy
• Acute Crisis Management (IV Glucose, Detoxification Agents)
• Gene Therapy (Research & Pipeline)

By Diagnosis Method
• Newborn Screening
• Plasma/Urine Metabolite Testing
• Genetic Testing

By End User
• Hospitals
• Specialty Metabolic Clinics
• Diagnostic Laboratories
• Home Care

By Region
• North America (Largest Market)
• Europe
• Asia-Pacific (Fastest Growing)
• Latin America
• Middle East & Africa
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Recent Developments
• Expansion of genetic testing platforms enabling earlier IVA detection.
• Advances in specialized low-leucine medical foods for long-term dietary support.
• Increased collaboration between metabolic disorder foundations and research institutions.

Expert Quote - Irfan Tamboli, Business Development Executive
"Earlier detection through newborn screening and better nutritional management strategies are significantly improving outcomes for patients with isovaleric acidemia. Continued research in metabolic genetics will advance treatment options further."

Conclusion
The Isovaleric Acidemia Market will continue to grow steadily through 2034 as early-diagnosis programs expand and metabolic management solutions improve. Companies offering specialized medical nutrition, diagnostic tools, and next-generation genetic therapies will drive future innovation.

This report is also available in the following languages : Japanese (イソ吉草酸血症市場), Korean (이소발레르산혈증 시장), Chinese (异戊酸血症市场), French (Marché de l'acidémie isovalérique), German (Markt für Isovalerianazidämie), and Italian (Mercato dell'acidemia isovalerica), etc.

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