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Rare Kidney Diseases Market Current Scenario with Future Aspect Analysis
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Rare kidney diseases are a group of uncommon renal disorders characterized by impaired kidney function, leading to the accumulation of toxins in the body and subsequent health complications. Many of these conditions have a genetic or hereditary basis and are infrequent in the general population. Some of the primary conditions within this category include Lupus Nephritis, Membranous Nephropathy, Focal Segmental Glomerulosclerosis (FSGS), IgA Nephropathy, and C3 Glomerulopathy. Among these, IgA nephropathy is marked by the deposition of IgA antibodies in kidney tissues, causing inflammation and potentially leading to kidney failure.
List of Prominent Players in the Rare Kidney Diseases Market:
• GlaxoSmithKline,
• Recordati Rare Diseases,
• Amicus Therapeutics,
• Calliditas Therapeutics,
• Alexion Pharmaceuticals (A subsidiary of AstraZeneca),
• Travere Therapeutics,
• Aurinia Pharmaceutical,
• Advicenne,
• Protalix Biotherapeutics,
• AstraZeneca,
• Chinook Therapeutics,
• Reata Pharmaceuticals,
• Roche,
• Novartis Pharmaceuticals,
• Merk & co.,
• Apellis Pharmaceuticals,
• Omeros Corporation,
• Lonza
Market Dynamics:
Drivers-
The market for rare kidney diseases is experiencing significant expansion, driven by multiple factors. One of the primary contributors to this growth is the expanding pipeline of novel treatments, with over 21,630 participants enrolled in clinical trials evaluating therapies at various developmental stages. The increasing prevalence of rare renal disorders worldwide has fueled the demand for innovative and effective treatments, leading to increased investments in this sector. Additionally, the integration of advanced technologies for biomarker identification has enhanced drug development success rates, further propelling market growth.
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Challenges:
Despite the progress in research and drug development, several challenges continue to hinder the expansion of the rare kidney disease market. Research funding and healthcare systems often prioritize common diseases, leaving rare kidney disorders underfunded and overlooked. Furthermore, limited data availability on these conditions creates gaps in research, healthcare policies, and clinical care. A lack of awareness among both medical professionals and patients about rare kidney diseases also delays diagnosis and treatment, restricting market growth.
Regional Trends:
North America is expected to dominate the rare kidney disease market, holding a substantial revenue share and registering a high compound annual growth rate (CAGR) in the coming years. Factors contributing to this include a rising incidence of rare renal conditions such as Fabry disease, lupus nephritis, nephropathic cystinosis, and atypical hemolytic uremic syndrome. Increased government and nonprofit funding for research, higher healthcare expenditure, early adoption of cutting-edge technologies, and greater acceptance of advanced diagnostic and therapeutic solutions are expected to drive regional growth.
Recent Developments:
• In August 2023, Novartis completed the purchase of US clinical-stage biopharmaceutical company Chinook Therapeutics. Chinook Therapeutics develops kidney-specific drugs. An initial $3.2 billion payment was made, with a possible $3.5 billion purchase value.
• In March 2024, Travere Therapeutics, Inc. filed a sNDA to the FDA to convert FILSPARI® (sparsentan)'s expedited approval in IgAN to full approval. FILSPARI, the first and only non-immunosuppressive medication to treat kidney glomerular degeneration and proteinuria in primary IgAN patients at risk of fast disease progression, received expedited FDA clearance in February 2023.
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Segmentation of Rare Kidney Diseases Market-
By Target Indication-
• IgA Nephropathy
• Lupus Nephritis
• Focal Segmental Glomerular Sclerosis
• Membranous Nephropathy
• C3 Glomerulopathy
• Cystinosis
• Dense Deposit Disease
• Distal Renal Tubular Acidosis
• Fabry Disease
• Refractory Gout
• Atypical Hemolytic Uremic Syndrome
• Others
By Type of Molecule-
• Small Molecules
• Biologics
o Monoclonal Antibody
o Hormone
o Recombinant Protein
o Others
By Route of Administration-
• Oral
• Intravenous
• Subcutaneous
• Others
By Region-
North America-
• The US
• Canada
• Mexico
Europe-
• Germany
• The UK
• France
• Italy
• Spain
• Rest of Europe
Asia-Pacific-
• China
• Japan
• India
• South Korea
• South East Asia
• Rest of Asia Pacific
Latin America-
• Brazil
• Argentina
• Rest of Latin America
Middle East & Africa-
• GCC Countries
• South Africa
• Rest of Middle East and Africa
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