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United States RNA-based Therapies Market Forecast 2025-2033: mRNA, siRNA & Gene-Modulating Drugs, Growth Drivers, Key Players & Investment Opportunities
RNA-based Therapies Market
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United States - Recent Industry Developments
✅ November 2025: Moderna advanced Phase III clinical trials for RNA-based therapeutics targeting rare genetic disorders beyond mRNA vaccines.
✅ October 2025: Alnylam strengthened commercial rollout of RNAi therapies for cardiovascular risk reduction across U.S. healthcare networks.
✅ September 2025: The FDA issued accelerated approval pathway updates to support rapid development of next-generation RNA-based immunotherapies.
GCC - Recent Industry Developments
✅ November 2025: UAE healthcare authorities announced investment programs to establish regional RNA therapy R&D and clinical trial facilities.
✅ October 2025: Saudi Arabia partnered with biotech leaders to develop localized RNA-based therapeutic manufacturing capabilities.
✅ September 2025: Qatar expanded precision medicine programs integrating RNA-based treatment strategies for hereditary disease patients.
MENA Region - Recent Industry Developments
✅ November 2025: Egypt launched collaborative research in RNA-driven oncology therapeutics with global pharma organizations.
✅ October 2025: Morocco prioritized RNA-based antiviral formulations in national innovation strategies for infectious disease preparedness.
✅ September 2025: Israel introduced next-gen self-amplifying RNA (saRNA) platforms to accelerate clinical translation of cancer vaccines.
Key Players:
Sarepta Therapeutics, Alnylam Pharmaceuticals, NS Pharma, Pfizer, Modern Therapeutics, Novartis, Biogen, and Novo Nordisk
Latest M&A
» Novartis confirmed a $12 billion acquisition of Avidity Biosciences in 2025, enhancing its neuromuscular RNA therapy pipeline with late-stage assets and precision delivery technology.
» Sanofi acquired Blueprint Medicines for $9.5 billion, incorporating RNA and gene therapy assets to expand its precision medicine offerings.
» AbbVie agreed to pay $2.1 billion for Capstan Therapeutics, gaining CAR-T and RNA delivery capabilities targeting autoimmune diseases, showcasing robust RNA-related deal activity.
Growth Forecast Projection:
The Global RNA-based Therapies Market is anticipated to rise at a considerable rate during the forecast period, between 2025 and 2032. In 2024, the market is growing at a steady rate, and with the rising adoption of strategies by key players, the market is expected to rise over the projected horizon.
Research Process:
Both primary and secondary data sources have been used in the global RNA-based Therapies Market research report. During the research process, a wide range of industry-affecting factors are examined, including governmental regulations, market conditions, competitive levels, historical data, market situation, technological advancements, upcoming developments, in related businesses, as well as market volatility, prospects, potential barriers, and challenges.
Latest Drugs and Product Launches
1. Astellas expanded FDA-approved indications for IZERVAYTM (avacincaptad pegol) for treating Geographic Atrophy, demonstrating RNA-based drug approvals expanding into retinal diseases.
2. Moderna drove oncology mRNA vaccine programs with long-term clinical data indicating improved patient outcomes, reinforcing RNA's expanding therapeutic reach.
3. BioNTech and other biotech firms advanced personalized mRNA cancer vaccines and immunotherapies in trials showing promising immune responses.
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Key Segmentation:
By Type: (Antisense Oligonucleotides (ASO), RNA interference, CRISPR/Cas-based RNA editing system, mRNA vaccines, RNA Aptamers, Others)
By Indication: (Rare Genetic Diseases, Oncology, Infectious Diseases, Neuromuscular, Others)
By End User: (Hospitals & Clinics , Research Institutes , Pharmaceutical & Biotech Companies)
Regional Analysis for Market:
⇥ North America (U.S., Canada, Mexico)
⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)
⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)
⇥ South America (Colombia, Brazil, Argentina, Rest of South America)
⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)
Benefits of the Report:
Chapter 1: Sets the stage by outlining the report's coverage, summarizing key market segments by region, product type, and application. Presents a snapshot of market sizes, growth potential across segments, and anticipated industry evolution both short and long term.
Chapter 2: Highlights pivotal market insights and uncovers the most significant emerging trends driving change within the industry.
Chapter 3: Offers an in-depth look at the competitive landscape among RNA-based Therapies producers, including revenue shares, strategic moves, and recent mergers and acquisitions.
Chapter 4: Presents comprehensive profiles of the market's key players, delving into details such as revenue, profit margins, product portfolios, and company milestones.
Chapters 5 & 6: Analyze RNA-based Therapies revenue at both regional and country levels, providing quantitative breakdowns of market sizes, growth opportunities, and development prospects worldwide.
Chapter 7: Focuses on different market segments by type, examining their individual sizes and potential, guiding readers toward high-impact, untapped market areas.
Chapter 8: Explores segmentation by application, evaluating industry growth potential in various downstream markets and pinpointing promising sectors for expansion.
Chapter 9: Provides a thorough review of the industry's supply chain mapping out both upstream and downstream activities.
Chapter 10: Concludes with a summary of the report's key findings and highlights the most critical takeaways for industry stakeholders.
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Clinical Trials
✦ Over 2,500 active RNA therapeutic clinical trials globally in 2025, addressing rare and common diseases with siRNA, mRNA, and antisense oligonucleotide modalities.
✦ Key ongoing trials include oral RNA drugs for cardiometabolic diseases and RNAi therapies combined with checkpoint inhibitors for cancer.
✦ Regulatory frameworks are evolving, with focus on safety, delivery efficacy, and functional outcome endpoints to support accelerated approval pathways.
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Latest Investments and Project Hubs
1. Montreal's CQDM launched a global RNA therapy innovation hub with $20.3 million government funding to boost RNA therapeutic research and accelerators in 2024-2025.
2. Haya Therapeutics raised $65 million Series A for RNA therapeutics targeting rare neurological and hepatic diseases, reflecting broad investor interest.
3. Quebec and other innovation hubs are leveraging AI and advanced RNA delivery platforms to overcome historic delivery challenges and expand RNA therapy applications
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Related Reports:
Small Interfering RNA (siRNA) Therapeutics Market:- https://www.datamintelligence.com/download-sample/small-interfering-rna-therapeutics-market?kb
RNAi Therapeutics Market: https://www.datamintelligence.com/research-report/rnai-therapeutics-market?kb
mRNA Vaccines Market: https://www.datamintelligence.com/research-report/mrna-vaccines-market---pipeline-insights?kb
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