Knockout Mouse Model Market to Reach US$1.96 Billion by 2031 | Conditional Knockout Segment Dominates with Precision Genetic Research Applications | DataM Intelligence

Leander, Texas and Tokyo, Japan - Nov 28, 2025
According to DataM Intelligence, the global knockout mouse model market size was worth US$1.37 billion in 2024 and is estimated to reach US$1.96 billion by 2031, growing at an estimated CAGR of 5.2% during 2024-2031. This steady growth is propelled by increasing genetic research activities, rising pharmaceutical R&D investments, growing demand for personalized medicine, advancements in gene editing technologies, and expanding applications in drug discovery and development.

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Report Details:
• No. of Pages: 180
• Forecast Period: 2024-2031
• Estimated Market Value (USD) in 2024: $1.37 Billion
• Forecasted Market Value (USD) by 2031: $1.96 Billion
• Compound Annual Growth Rate: 5.2%
• Regions Covered: Global

United States Recent Developments:
✅ The Jackson Laboratory launched next-generation conditional knockout models with enhanced tissue-specific gene targeting capabilities for precision oncology research
✅ Charles River Laboratories introduced CRISPR-Cas9 optimized knockout models with improved efficiency and reduced off-target effects
✅ NIH expanded funding for knockout mouse repositories supporting rare disease research and therapeutic development

Japan Recent Developments:
✅ RIKEN BioResource Center developed specialized conditional knockout models for aging and neurodegenerative disease research
✅ Japan's MEXT increased grants for humanized knockout mouse models in immunology and infectious disease studies
✅ Takeda Pharmaceuticals established dedicated knockout model facilities for metabolic disorder drug screening programs

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Competitive Landscape
The market features strong competition between specialized research organizations, biotechnology companies, and academic research institutions.

1. The Jackson Laboratory maintained market leadership with 32% global market share, expanding their conditional knockout portfolio and reporting 28% revenue growth in 2024-2025 through research institution partnerships.
2. Charles River Laboratories captured 26% market share in pharmaceutical applications, securing long-term contracts with biopharma companies and achieving 25% growth through customized model development.
3. Taconic Biosciences dominated the constitutive knockout segment with 20% market share, reporting 22% growth through standardized model offerings.
4. Crown Bioscience led oncology research models with 15% market share, achieving 24% growth through targeted cancer model development.
5. Genoway expanded their protein function knockout portfolio with 12% market share, focusing on functional genomics with 20% revenue growth.

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Segmentation Analysis
By Type
• Conditional Knockout Mouse segment is expected to dominate the global knockout mouse model market with 45% revenue share in 2024, projected to grow at 6.1% CAGR, valued for temporal and spatial control of gene expression, reduced embryonic lethality, precise disease modeling capabilities, and widespread adoption in complex genetic studies requiring controlled gene manipulation.
• Constitutive Knockout Mouse shows steady growth with 35% revenue share in 2024, expected to grow at 4.5% CAGR, preferred for complete gene deletion studies and straightforward genetic screening applications.
• Protein Function Knockout Mouse demonstrates significant expansion with 20% revenue share in 2024, growing at 5.3% CAGR, valued for specific functional domain studies and targeted protein research.

By End-User
• Pharma & Biotechnology Companies represents the largest segment with 48% revenue share in 2024, growing at 5.8% CAGR, driven by extensive drug discovery programs, target validation requirements, preclinical testing needs, and essential role in therapeutic development pipelines across oncology, metabolic disorders, neurological conditions, and rare genetic diseases.
• Clinical Research Organizations shows robust growth with 35% revenue share in 2024, expanding at 5.1% CAGR, valued for contract research services, academic collaborations, and multicenter study support.
• Other end-users demonstrate consistent demand from academic and government research institutions.

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Regional Analysis:
North America holds the largest market share with 44% revenue share in 2024, driven by advanced research infrastructure, significant pharmaceutical R&D investments, strong academic research programs, well-established biotechnology sector, and substantial government funding for genetic research across the United States and Canada.

Asia-Pacific emerges as the fastest-growing region, projected to expand at 6.8% CAGR through 2031, fueled by increasing research funding, growing pharmaceutical outsourcing, expanding academic research capabilities, rising genetic disease prevalence, and improving research infrastructure across China, Japan, South Korea, and India.

Market Trends & Drivers
The Knockout Mouse Model Market is experiencing steady growth driven by genetic research advancement, drug discovery evolution, technological innovation in gene editing, and expanding therapeutic applications. Key trends include the development of humanized knockout models, growth of CRISPR-Cas9 technologies, advancement in conditional and inducible systems, expansion of multi-gene knockout models, and increasing focus on disease-specific model development. The genetic research expansion, therapeutic innovation, and technological advancement are significantly contributing to market growth.

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