Circular RNA (CircRNA) Platforms Market to Reach USD 999 Million by 2035 Amid Rising RNA Therapeutics Demand

The Circular RNA (CircRNA) Platforms Market is emerging as one of the fastest-growing segments in the biotechnology and RNA therapeutics landscape. With an estimated valuation of ~USD 213 million in 2025, the market is projected to reach ~USD 999 million by 2035, registering a robust CAGR of 16.7%. This growth is driven by rising applications in therapeutics, diagnostics, precision medicine, and drug discovery, as well as advancements in RNA synthesis and design technologies.

As innovation accelerates, companies across the circular RNA technology solutions market are investing in next-generation circRNA platforms that outperform traditional mRNA therapies in stability, durability, and efficiency.

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Rising Applications Fuel Market Growth

The Circular RNA (CircRNA) Platforms Market is gaining traction due to its transformative potential across various disease areas. circRNA molecules exhibit exceptional molecular stability, resistance to exonuclease degradation, and prolonged protein expression-features that make them ideal for next-generation therapeutics.

Key applications include:

Oncology and cancer therapeutics
Neurological and metabolic disorders
Rare genetic diseases
Infectious disease vaccines
Autoimmune and inflammatory conditions
The growing recognition of circRNA's therapeutic advantages is accelerating adoption across the global circular RNA technology solutions market, with advanced platforms enabling high-quality synthesis, design optimization, target validation, and delivery.

Therapeutic Development Dominates the Market

Therapeutic development accounts for 61% of the global market share in 2025. Biotechnology companies and academic institutions are leveraging circRNA to build highly targeted, stable, and scalable therapies.

Recent scientific advancements underscore this momentum:

Circio's circVec-AAV vectors (2025): Demonstrated up to 40-fold higher protein expression in vivo, reducing viral dosage requirements and making gene therapies safer and more cost-effective.
RiboX Therapeutics (Phase I/IIa): Successfully evaluated RXRG001, a circRNA therapy for radiation-induced xerostomia, demonstrating long-term activity and therapeutic stability.
Such developments reinforce the strong pipeline of candidates emerging from the broader circular RNA technology solutions market, with companies innovating across sequencing, synthesis, delivery, and computational design.

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Demand Surge Driven by Precision Medicine & Drug Discovery

The demand for circRNA platforms is rapidly increasing as precision medicine programs expand globally. Pharmaceuticals and biotech organizations are adopting circRNA systems to support:

High-throughput drug discovery
Personalized RNA therapeutics
Predictive molecular profiling
Advanced gene-modulating therapies
The Circular RNA (CircRNA) Platforms Market is also benefiting from growing interest in AI-enhanced RNA design. Platforms like CircNova's AI-powered NovaEngine streamline circRNA prediction, structural optimization, and synthesis, significantly accelerating development timelines.

Key Market Drivers

Growing Therapeutic Potential in Oncology
circRNA is becoming a cornerstone of next-generation cancer therapies due to its enhanced stability and long-lasting protein expression.

Ginkgo Bioworks & Esperovax Inc. collaborated to develop circRNA therapeutics for colorectal cancer.
Circio's circAde builds on ONCOS-102 results, demonstrating strong anti-tumor immune responses.
Such innovations amplify investments across the circular RNA technology solutions market, delivering strong momentum for oncology-focused R&D.

Advancements in circRNA Delivery Technologies
Efficient delivery remains a critical component of circRNA therapeutic success.

Leading breakthroughs include:

Orna Therapeutics' panCAR platform: Achieved 84% T-cell uptake using LNP-based circRNA delivery, resulting in 95% reduction in B cells.
Lipid nanoparticles, polymeric carriers, and exosome-based systems continue to enhance targeted delivery and reduce immunogenicity.
AI-Driven Innovation
AI is revolutionizing circRNA design, enabling:

Predictive modeling
High-precision molecule synthesis
Structural optimization
Target-specific circRNA development
Integration of AI strengthens both the Circular RNA (CircRNA) Platforms Market and the large ecosystem of circular RNA technology solutions used for discovery, design, and therapeutic development.

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Challenges Hindering Market Expansion

Despite strong growth, certain restraints are slowing commercialization:

High complexity of circRNA production
Lack of standardized purification protocols
High cost of large-scale manufacturing
Regulatory uncertainties in new RNA modalities
These challenges present opportunities for technology innovators to disrupt the circular RNA technology solutions market with scalable, standardized, and automated circRNA production platforms.

North America Leads the Market

North America holds ~45% market share in 2025 owing to:

Advanced healthcare infrastructure
Robust regulatory frameworks
Strong academic-industry partnerships
High biotechnology investment activity
Institutions like the University of Pennsylvania and Mass General Brigham are pioneering circRNA manufacturing, delivery innovation, and personalized RNA therapeutics.

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Competitive Landscape

The Circular RNA (CircRNA) Platforms Market is moderately consolidated. Key players include:

GenScript Biotech
Oxford Nanopore Technologies
Illumina
Orna Therapeutics
Laronde
Arraystar
Creative Biogene
Circio
CloudSeq Biotech
These companies dominate the circular RNA technology solutions market, offering advanced sequencing, synthesis, bioinformatics, and delivery technologies tailored for circRNA applications.

Future Opportunities: A Market Poised for Transformation

The global Circular RNA (CircRNA) Platforms Market will create an additional USD 785.8 million in new opportunities by 2035. Emerging areas with high market potential include:

Tissue-specific circRNA therapeutics
Oncology and immunotherapy innovations
Vaccine development using thermostable circRNA nanoparticles
circRNA-based microRNA sponges and decoys
AI-enhanced circRNA functional mapping
Next-generation LNPs tailored specifically for circular RNA
Development of endogenous circRNA modulators and synthetic circRNA libraries is expected to significantly boost pipeline diversity.

Contact:

Mr. Debashish Roy

MarketGenics India Pvt. Ltd.

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This release was published on openPR.