United States Protein A Resin Market 2025 | Growth Drivers, Trends & Market Forecast, Competitive Landscape & Investment Opportunities

Market Size and Growth

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Key Development:

United States: Recent Protein A Resin Developments

✅ In October 2025, Merck (MilliporeSigma in the U.S.) signed a definitive agreement to acquire the chromatography business of JSR Life Sciences, bringing JSR's AmsphereTM Protein A resin technology into its downstream portfolio.

✅ In October 2025, JSR announced the transfer of its bioprocess materials business (including AmsphereTM A3 and A+) to Merck, aligning with its strategy to re‐focus resources while scaling the resin technology globally.

✅ In 2025, Cytiva (formerly GE) continues to dominate with its high-performance MabSelect series, addressing surging monoclonal antibody purification demand.

Japan: Recent Protein A Resin Developments

✅ In October 2025, Merck's acquisition of JSR's chromatography business (including its AmsphereTM A-series Protein A resins) marks a major consolidation in Japan's resin innovation space.

✅ In mid‐2025, the Japanese Protein A resin market is projected to grow, driven by rising adoption of recombinant ligands and innovations in downstream bioseparation.

✅ In 2025, reports highlight increasing demand in Japan for recombinant Protein A resins (e.g., agarose-based) from biopharma players, reflecting maturation of the local mAb and biosimilar manufacturing infrastructure.

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Key Players:

=> GE Healthcare, Bio-Rad Laboratories, Inc., Merck KGaA, Thermo Fisher Scientific Inc., Tosoh Bioscience LLC, Cytiva, IPSUM LIFESCIENCES LLP, Repligen Corporation, Purolite Corporation and Avantor Inc among others.

Growth Drivers of Protein A Resin:

✅ Rising demand for monoclonal antibodies (mAbs) in therapeutic and diagnostic applications is driving growth.

✅ Technological advancements in resin design improving binding capacity, selectivity, and stability.

✅ Expansion of biopharmaceutical manufacturing and contract manufacturing organizations (CMOs).

✅ Increasing adoption of automated and high-throughput purification systems in bioprocessing.

✅ Growing focus on cost-effective, high-yield downstream processing solutions.

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Key Segments:

➥ By Product Type: Agarose-Based Protein A Resins, Silica-Based Protein A Resins, Magnetic Protein A Resins, Organic Polymer-based Protein A Resins, Others

➥ By Application: Monoclonal Antibody Production, Antibody Purification, Immunoprecipitation, Others

➥ By End-User: Biotechnology Companies, Pharmaceutical Companies, Biopharmaceutical Companies, Academic and Research Institutes, Others

Regional Analysis

North America (≈35% share)
The U.S. dominates due to strong biopharmaceutical R&D, mAb production, and presence of leading Protein A resin manufacturers. Canada supports academic and clinical research, while Mexico is gradually expanding in biotechnology and pharma sectors. Favorable regulatory frameworks, high adoption of advanced purification technologies, and strong venture funding accelerate growth.

Europe (≈28% share)
Germany, the U.K., and France lead antibody production and purification activities. Northern and Southern Europe focus on research institutes and biopharma companies. EU regulations promote high-quality, standardized resins, while environmental and process safety standards drive innovation in resin design and performance.

Asia-Pacific (≈24% share)
China, India, and Japan drive growth with expanding biopharmaceutical manufacturing and R&D in monoclonal antibodies. South Korea and Australia focus on research and clinical applications. Rapid investments in biotech infrastructure, growing pharma outsourcing, and government support for bioprocessing fuel adoption.

Latin America (≈6% share)
Brazil, Argentina, and Mexico are emerging markets for antibody production and purification. Limited local manufacturing encourages imports, while partnerships with global biopharma companies enhance market access.

Middle East & Africa (≈7% share)
GCC countries, South Africa, and select African nations are adopting Protein A resins for research, diagnostics, and clinical biopharmaceutical activities. Investments in biotech infrastructure, research centers, and public-private collaborations are gradually expanding market presence.

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