Global Oligonucleotide Synthesis Market Expected to Achieve 16.8% CAGR by 2029: Growth Forecast Insights

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How Large Will the Oligonucleotide Synthesis Market Size By 2025?
The oligonucleotide synthesis market has expanded rapidly in recent years. It is projected to increase from $10.33 billion in 2024 to $11.92 billion in 2025, registering a compound annual growth rate (CAGR) of 15.3%. The growth during the historic period can be attributed to advancements in biomedical research, progress in therapeutic development, innovations in biotechnology, the expansion of genomic studies, and the rising adoption of DNA-based technologies.

How Big Is the Oligonucleotide Synthesis Market Size Expected to Grow by 2029?
Anticipation surrounds the oligonucleotide synthesis industry, predicting substantial expansion across the coming years; by 2029, the market valuation is projected to reach $22.2 billion, reflecting a compound annual growth rate (CAGR) of 16.8%. This projected surge in the coming period is fueled by several key factors, such as the proliferation of novel diagnostic instruments, the development of RNA interference (RNAi) based therapeutics, progress in regenerative medicine, expanded uses in nanotechnology, and significant strides made in gene editing techniques. Furthermore, several important shifts are shaping this market moving forward, notably including focused efforts in drug design, the introduction of novel methods for therapeutic delivery, the increasing reliance on automated synthetic processes, the adoption of CRISPR-cas technology, and the ongoing evolution of next-generation sequencing (NGS).

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Which Key Market Drivers Powering Oligonucleotide Synthesis Market Expansion and Growth?
Anticipated expansion in the oligonucleotide synthesis market is fueled by the increasing incidence of long-term ailments, defined as conditions persisting for a year or more necessitating ongoing medical care that often deteriorates over time. Through several pathways, these oligonucleotides exert influence on the genetic expression underpinning these persistent health issues, capable of interacting with messenger RNA, precursor forms, or RNA segments that do not code for protein to adjust how splicing occurs, prompt breakdown, or obstruct the creation of proteins. To illustrate this global health reality, data from the World Health Organization, a United Nations body headquartered in Switzerland, indicated that as of September 2022, fatalities totaled 41 million annually, with a substantial 74 percent stemming from non-communicable diseases, or chronic conditions; specifically, cardiovascular ailments accounted for 17.9 million of these deaths, cancers for 9.3 million, persistent respiratory illnesses for 4.1 million, and diabetes for 2.0 million, thereby establishing the escalating frequency of both chronic and uncommon diseases as a key impetus behind the growth trajectory of the oligonucleotide synthesis sector.

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Which Fast-Growing Trends Are Poised to Disrupt the Oligonucleotide Synthesis Market?
A significant driving force presently observed within the oligonucleotide synthesis market centers on advancements in product innovation, compelling established market participants to introduce novel offerings to maintain their competitive edge. Specifically, in July of 2024, the United States firm Ansa Biotechnologies, Inc., recognized for its production of sophisticated DNA materials, introduced two new items: Ansa Clonal DNA and Ansa DNA Fragments. The former, Ansa Clonal DNA, delivers sequence-perfect, clonal DNA ranging up to 600 base pairs, thereby obviating any requirement for subsequent assembly steps and delivering superior accuracy indispensable for intricate synthetic biology undertakings; this ensures researchers receive DNA sequences that are both error-free and immediately usable. Complementing this is Ansa DNA Fragments, which supplies sequence-verified, linear double-stranded DNA segments, also capped at 600 base pairs, intended to serve a broad spectrum of investigative uses; through the utilization of its novel enzymatic synthesis methodology, Ansa successfully and precisely yields complex DNA structures, specifically those incorporating secondary features or repetitive elements.

What Are the Emerging Segments in the Oligonucleotide Synthesis Market?
The oligonucleotide synthesismarket covered in this report is segmented -

1) By Type: Custom Oligos; Predesigned Oligos
2) By Product Type: Oligonucleotides; Reagents; Equipment; Services; Purification; Modification
3) By Application: Therapeutic Applications; Research Applications; Diagnostic Applications

Subsegments:
1) By Custom Oligos: Long Oligonucleotides; Short Oligonucleotides; Modified Oligonucleotides
2) By Predesigned Oligos: Gene-Specific Oligos; Probe Oligos; Primers For PCR And RT-PCR

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Who Are the Global Leaders in the Oligonucleotide Synthesis Market?
Major companies operating in the oligonucleotide synthesis market include Thermo Fisher Scientific Inc., Danaher Corporation, Merck KGaA, GE HealthCare Technologies Inc., Eurofins Scientific SE, Agilent Technologies Inc., Nitto Denko Avecia Inc., Alnylam Pharmaceuticals Inc., Maravai Life Sciences, LGC Limited, Ionis Pharmaceuticals Inc., GenScript Inc., Ajinomoto Bio-Pharma Services, Sarepta Therapeutics Inc., Integrated DNA Technologies Inc., Twist Bioscience Corporation, Eurogentec SA, Kaneka Eurogentec S.A., Biocomma Limited, Bio-Synthesis Inc., TriLink BioTechnologies Incorporated, Generi Biotech s.r.o., ATDBio Ltd., BioAutomation Corporation, Biolegio B.V., Dharmacon Research Inc.

Which are the Top Profitable Regional Markets for the Oligonucleotide Synthesis Industry?
North America was the largest region in the oligonucleotide synthesis market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the oligonucleotide synthesis market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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