Heart Failure Drugs Market to Reach USD 19.4 Billion by 2034

Increasing prevalence of cardiovascular diseases, strong clinical outcomes from ARNI and SGLT2 inhibitors, and growing treatment accessibility are accelerating global market expansion.

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Introduction
The global Heart Failure Drugs Market is entering a high-growth phase as new drug classes transform treatment and survival outcomes for millions worldwide. With cardiovascular diseases continuing to be the leading cause of mortality, the shift toward evidence-backed therapies such as ARNI (angiotensin receptor-neprilysin inhibitors) and SGLT2 inhibitors is reshaping clinical practice. This press release presents the latest market data, developments, and expert insights from Exactitude Consultancy.

Key Takeaways
• Market Size 2024: USD 12.8 Billion
• Forecast for 2034: USD 19.4 Billion
• CAGR (2025-2034): 4.3%
• Growth Accelerators: ARNI adoption, SGLT2 dual-benefit therapy, advanced hospital/clinic infrastructure, and proactive screening programs
• Therapeutic Classes Leading Growth: ARNI, Beta Blockers, SGLT2 inhibitors
• Key Regions: North America leads; Asia-Pacific is the fastest-growing

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Market Story
The Heart Failure Drugs Market is witnessing rapid evolution fuelled by strong clinical evidence supporting new-generation therapies. The introduction of Sacubitril/Valsartan, cardioprotective SGLT2 inhibitors, and combination therapies has significantly improved patient survival and reduced hospitalization rates. Governments and healthcare systems are broadening heart failure screening programs, while pharmaceutical innovation focuses on therapies targeting underlying mechanisms like fibrosis reduction, metabolic modulation, and molecular repair.

In emerging economies, improved diagnostic rates and better treatment affordability are unlocking new opportunities for drug manufacturers. Meanwhile, the global ageing population continues to expand the core patient pool.

Market Segments
By Drug Class
• ACE Inhibitors
• ARNI (Highest Growth Segment)
• SGLT2 Inhibitors
• Beta Blockers
• Aldosterone Antagonists
• Vasodilators
• Diuretics

Growth Insight:
SGLT2 inhibitors and ARNI therapies are projected to grow at over 7% CAGR due to superior outcomes in both HFrEF and HFpEF patients.

By Distribution Channel
• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies (Fastest-growing due to convenience and chronic disease home management)

By Region
• North America: Largest market due to drug uptake, rapid regulatory approvals
• Europe: Strong reimbursement support and clinical research presence
• Asia Pacific: Fastest growth driven by expanding cardiac care facilities in India, China, Japan
• South America & Middle East/Africa: Steady growth with improving healthcare accessibility

Recent Developments
• 2024: Multiple clinical trials showed significantly reduced mortality with SGLT2 inhibitors for HF patients with and without diabetes.
• 2025: FDA considering expanded indication for ARNI therapies to include earlier stages of cardiac dysfunction.
• 2025: Leading pharma players launched patient-assistance initiatives across emerging regions to increase adherence.
• 2023-2025: Growing pipeline of anti-fibrotic HF drugs entering Phase 2 and Phase 3 trials.

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Expert Quote
"The Heart Failure Drugs Market is transforming rapidly as ARNI and SGLT2 inhibitors redefine the standard of care. Over the next decade, we expect broader treatment penetration, earlier intervention, and more combination-based drug strategies,"
- Irfan Tamboli, Business Development Executive, Exactitude Consultancy

Key Market Drivers
• Rising global burden of hypertension, diabetes, and coronary artery disease
• Advancements in guideline-directed medical therapy for HF
• Increasing government funding for cardiovascular care
• Strong clinical evidence supporting new drug classes
• Growing availability of telecardiology and remote prescription services

Forecast & Future Outlook
The Heart Failure Drugs Market will surpass USD 19 billion by 2034, driven by:
• Expanded prescribing of SGLT2 inhibitors for HF across all ejection fractions
• Wider adoption of ARNI therapy as first-line treatment
• Pharma investments in next-gen antifibrotic and regenerative HF therapies
• Integration of digital-health tools for medication adherence monitoring
Asia-Pacific will emerge as the fastest-growing region, contributing the highest incremental revenue by 2034.

Conclusion
As cardiovascular disease rates continue to rise worldwide, the Heart Failure Drugs Market is poised for strong long-term growth. The emergence of highly effective drug classes, combined with supportive healthcare policies and increased patient awareness, will make advanced HF therapies more accessible across global markets.

This report is also available in the following languages : Japanese (心不全治療薬市場), Korean (심부전 치료제 시장), Chinese (心力衰竭药物市场), French (Marché des médicaments contre l'insuffisance cardiaque), German (Markt für Herzinsuffizienzmedikamente), and Italian (Mercato dei farmaci per l'insufficienza cardiaca), etc.

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About Us
Exactitude Consultancy is a market research & consulting services firm which helps its client to address their most pressing strategic and business challenges. Our market research helps clients to address critical business challenges and also helps make optimized business decisions with our fact-based research insights, market intelligence, and accurate data.
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This release was published on openPR.