Press release
North America Metabolic Dysfunction-Associated Steatohepatitis (MASH) Treatment Market to hit US$ 17.15 billion by 2033
North America Metabolic Dysfunction-Associated Steatohepatitis (MASH) Treatment Market
DataM Intelligence has released its latest report on the "North America Metabolic Dysfinction Associates Steatohepatitis Mash Treatment Market Size 2025," providing a detailed analysis of market trends, key growth drivers, competitive landscape, and regional insights. The report includes market size (value and volume), CAGR projections, and emerging opportunities that help businesses identify growth areas and build effective strategies. Backed by data-driven insights and future outlook, this study serves as a valuable resource for companies looking to stay competitive and capitalize on market potential.
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Latest M&A
Novo Nordisk's $5.2 billion acquisition of Akero Therapeutics (2025) expanded its metabolic disease portfolio with Akero's late-stage FGF21 analog efruxifermin targeting MASH and liver fibrosis, solidifying its U.S. presence as a leader in metabolic therapeutics.
Roche's deal to acquire 89bio brought additional pipeline assets for MASH treatment in North America, boosting presence in liver disease R&D and advanced therapies.
Other emerging biotech acquisitions include companies with novel thyroid hormone receptor beta agonists and fibrosis-targeting assets aiming to address chronic liver diseases.
Key Player:
Novo Nordisk A/S, Boehringer Ingelheim International GmbH, 89bio, Inc., Inventiva, Sagimet Biosciences, and Akero Therapeutics, Inc.
Latest News & Pipeline Developments
The FDA approved semaglutide (Wegovy) in 2025 for treatment of non-cirrhotic MASH with stage 2 or 3 fibrosis based on ESSENCE trial data, supporting improved liver function and fibrosis regression in the U.S. market.
Early real-world data suggests semaglutide reduces MASH progression and need for liver transplants.
Additional promising candidates in North America include resmetirom (Rezdiffera) by Madrigal Pharmaceuticals, approved for MASH, and evoltrasiran (Alnylam) targeting liver fibrosis in late clinical trials.
Multiple trials for combination therapies involving PPAR agonists, FXR agonists, and FGF21 analogs are ongoing in the U.S.
Forecast Projection:
The global North America Metabolic Dysfinction Associates Steatohepatitis Mash Treatment market is set to witness strong growth from 2025 to 2032. After maintaining steady momentum in 2024, the market is expected to accelerate as key industry players implement strategic initiatives to boost adoption. Companies that adapt to these emerging trends will be well-positioned to capture new opportunities and enhance their revenue potential throughout the forecast period.
Market Intelligence Research Process:
The North America Metabolic Dysfinction Associates Steatohepatitis Mash Treatment Market Report by DataM Intelligence offers a comprehensive analysis built on a mix of primary and secondary research. It explores key factors driving the industry, including government policies, market trends, competitive landscape, technological advancements, and upcoming innovations. This in-depth study uncovers both growth opportunities and potential challenges, helping businesses navigate market fluctuations and make data-driven decisions for sustainable success.
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Key Segmentations:
By Stage: (Stage 4, Stage 2-3, Stage 0-1)
By Age Group: (Geriatrics, Adults, Pediatrics)
By Gender: (Male, Female)
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FAQ's
Q1: How large is the North America Metabolic Dysfinction Associates Steatohepatitis Mash Treatment Market?
Ans: The North America Metabolic Dysfinction Associates Steatohepatitis Mash Treatment Market size was valued at US$ 3.70 billion in 2024 and is projected to grow to US$ 17.15 billion by 2033
Q2: How quickly is the North America Metabolic Dysfinction Associates Steatohepatitis Mash Treatment Market expanding?
Ans: The North America Metabolic Dysfinction Associates Steatohepatitis Mash Treatment Market is forecasted to grow at a CAGR of 17.15 % between 2025 and 2032, showing Annual growth momentum
FDA Approvals and Guidance
FDA approval for semaglutide specifically for MASH marks a milestone for treating metabolic liver disease in early stages.
FDA supports accelerated approval pathways using biomarkers and histological surrogates for MASH drug approvals, expediting North American commercialization.
Updated U.S. clinical guidelines emphasize early diagnosis and integrated management with pharmacologic and lifestyle approaches in MASH patients.
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Reimbursement Trends in North America
Medicare and private health insurers have expanded reimbursement coverage for FDA-approved MASH drugs, including semaglutide and resmetirom, facilitating broad patient access via specialty pharmacies.
Value-based contracting and real-world evidence programs encourage payers to support therapies that demonstrate slowed disease progression and reduced hospitalization costs.
Pricing negotiations focus on balancing innovation reimbursement with budget impact given the high prevalence of fatty liver disease in U.S. populations.
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DataM Intelligence is a Market Research and Consulting firm that provides end-to-end business solutions to organizations from Research to Consulting. We, at DataM Intelligence, leverage our top trademark trends, insights and developments to emancipate swift and astute solutions to clients like you. We encompass a multitude of syndicate reports and customized reports with a robust methodology.
Our research database features countless statistics and in-depth analyses across a wide range of 6300+ reports in 40+ domains creating business solutions for more than 200+ companies across 50+ countries; catering to the key business research needs that influence the growth trajectory of our vast clientele.
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