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Cystic Fibrosis (CF) Market Report | Emerging Biopharma Players & Clinical Pipeline Updates | Gilead sciences, Alcresta Therapeutics Inc, Merck & Co. Inc, Pfizer Inc, Genentech, Chiesi Pharmaceuticals B.V
Cystic Fibrosis Market
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Latest M&A in Cystic Fibrosis
4D Molecular Therapeutics (4DMT) received $11 million in additional funding from the Cystic Fibrosis Foundation to advance its gene therapy candidate 4D-710 for CF treatment, entering Phase 2 trials in 2025.
Major pharmaceutical M&A in 2025 include large deals in metabolic and rare diseases, impacting CF research investments indirectly.
Venture capital and private equity continue funding CF-focused biotech startups developing novel CFTR modulators and gene therapies.
List of Top Key Player:
Novartis AG, Vertex Pharmaceuticals Inc, F. Hoffmann-La Roche Ltd, Teva Pharmaceutical Industries Ltd, Gilead sciences, Alcresta Therapeutics Inc, Merck & Co. Inc, Pfizer Inc, Genentech, Chiesi Pharmaceuticals B.V.
Latest News & Market Trends
The US CF therapeutics market was valued at around $2.32 billion in 2024 and is expected to grow to $4.72 billion by 2033 driven by advances in CFTR modulators and gene therapy.
Several clinical trials are underway testing new therapies addressing chronic lung infections, inflammation, and gene correction.
A novel inhaled antibiotic combination (RSP-1502) pioneered in Western Australia showed promising Phase 1b results and entered Phase 2 trials to treat lung infections in CF patients.
Generic versions of inhaled tobramycin, an antibiotic for bacterial lung infections in CF, received FDA approval in November 2025, expanding access.
Forecast Projection:
The Global Cystic Fibrosis Market is poised for significant growth between 2025 and 2032. In 2024, the market maintained a steady upward trajectory, and with strategic initiatives by leading players accelerating adoption, the market is expected to soar throughout the forecast period. Companies leveraging these trends are well-positioned to capture emerging opportunities and maximize revenue potential.
Market Intelligence Research Process:
The Cystic Fibrosis Market research report by DataM Intelligence combines primary and secondary data to deliver deep, actionable insights. It examines the full spectrum of factors shaping the industry, from government regulations and market conditions to competitive dynamics, historical trends, technological breakthroughs, upcoming innovations, and potential challenges. This comprehensive analysis not only highlights growth prospects but also identifies barriers, equipping businesses to navigate market volatility and capitalize on emerging opportunities.
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Key Segmentation:
By Drug Class: (CFTR Modulators, Antibiotics, Pancreatic Enzyme Supplements, Mucolytics, Bronchodilators, Others)
By Route of Administration: (Oral, Inhaled, Parenteral)
By Distribution Channel: (Hospital Pharmacies, Retail Pharmacies, Online Pharmacies)
Global Growth Regional Analysis:
⇥ North America (U.S., Canada, Mexico)
⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)
⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)
⇥ South America (Colombia, Brazil, Argentina, Rest of South America)
⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)
Latest FDA Approvals
FDA granted approval to Vertex Pharmaceuticals' Alyftrek for CF patients aged 6 and older with common CFTR mutations in 2024-2025 and continues expanding indications.
Generic tobramycin inhalation solution approved by FDA in late 2025 provides an affordable option for CF lung infection treatment.
Other pipeline approvals focus on CFTR modulators, anti-inflammatory agents, and gene therapies.
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Reimbursement Updates
Belgium extended full reimbursement of Kaftrio (CFTR modulator) to children aged 2 to 5 years starting February 2025, with clinical trials ongoing for younger babies.
Global reimbursement frameworks are adapting to novel gene therapies and CF treatments, balancing high drug costs with long-term health benefits.
Insurance coverage is progressively improving access for CF patients worldwide, supported by advocacy groups.
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Drugs Related to Cystic Fibrosis
Key CF drugs include CFTR modulator combinations like Trikafta (elexacaftor/tezacaftor/ivacaftor), Kaftrio, and the newly approved Alyftrek.
Antibiotics like inhaled tobramycin and novel antibiotic boosters like RSP-1502 address chronic lung infections common in CF.
Gene therapies (4D-710) and anti-inflammatory agents are in development to expand therapeutic options.
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DataM Intelligence is a Market Research and Consulting firm that provides end-to-end business solutions to organizations from Research to Consulting. We, at DataM Intelligence, leverage our top trademark trends, insights and developments to emancipate swift and astute solutions to clients like you. We encompass a multitude of syndicate reports and customized reports with a robust methodology.
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