United States Healthcare E-Commerce Industry Insights | Growing Online Demand for Medical Devices & Rx Drugs

DataM Intelligence has published a new research report on ""Healthcare E-Commerce Market Size 2025"". The report explores comprehensive and insightful Information about various key factors like Regional Growth, Segmentation, CAGR, Business Revenue Status of Top Key Players and Drivers. The purpose of this report is to provide a telescopic view of the current market size by value and volume, opportunities, and development status.

eBay, a leading US-based e-commerce company, acquired CareDash, a well-known online healthcare marketplace, gaining access to its extensive user base and network of healthcare providers. Meanwhile, Walmart, another major US corporation, announced a $3 billion investment in its healthcare division over the next three years to strengthen its presence in the sector.

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Major Healthcare E-Commerce M&A Deals in 2025 by Value

Inari Medical was acquired by Stryker for $4.9 billion in February 2025, broadening Stryker's interventional endovascular portfolio.​

The Carlyle Group acquired Vantive for $3.8 billion in early 2025, establishing a standalone kidney care business focused on specialty healthcare services.​

Other significant deals include Cardinal Health's $2.8 billion acquisition of GI Alliance, strengthening specialty care services.​

These deals demonstrate strategic consolidation targeting specialty care and digital health services that seamlessly integrate with e-commerce and telehealth infrastructure.

Latest M&A Activity

Healthcare e-commerce M&A activity remains strong in 2025, driven by digital transformation across pharmaceutical distribution, medical supplies, and virtual care platforms.

According to Corum Group, 277 healthtech M&A deals occurred in H1 2025, on pace to exceed full-year 2024 volume with disclosed deal values exceeding $10 billion, likely much higher in total.

Strategic, financial, and tech-driven buyers focus on SaaS platforms, telehealth integration, supply chain digitization, and virtual fulfillment solutions.​

Major deals include Teladoc Health's $65M acquisition of Catapult Health to boost at-home diagnostic services and BioMatrix Infusion Pharmacy's acquisition of Mylyfe Health, extending specialty pharmacy reach

Key Players:

Amazon, Alibaba Group Holding Ltd., EBay Inc, Remdi SeniorCare, CVS Health, MedLife, Netmeds, Doc Morris, Kroger Co. and McCabes Pharmacy.

Regulatory Landscape & FDA Approvals

Healthcare e-commerce is highly regulated to ensure patient safety, data security, and compliance with HIPAA, FDA, and DEA guidelines for pharmaceutical sales and telehealth services.

FDA regulates approvals of drugs sold, but also maintains oversight on e-prescribing software and digital health platforms integrated into e-commerce.

The Digital Health Center of Excellence continues to streamline digital health device approvals and foster innovation in connected health tools, including telepharmacy and remote patient monitoring.​

Emerging regulations focus on real-time data exchange standards, secure tele-pharmacy, and AI/ML tools for fraud prevention and compliance in healthcare e-commerce

Growth Forecast Projected:

The Global Healthcare E-Commerce Market is anticipated to rise at a considerable rate during the forecast period, between 2025 and 2032. In 2024, the market is growing at a steady rate, and with the rising adoption of strategies by key players, the market is expected to rise over the projected horizon.

Research Process:

Both primary and secondary data sources have been used in the global Healthcare E-Commerce Market research report. During the research process, a wide range of industry-affecting factors are examined, including governmental regulations, market conditions, competitive levels, historical data, market situation, technological advancements, upcoming developments, in related businesses, as well as market volatility, prospects, potential barriers, and challenges.

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Key Segments:

By Type: (Drug, Medical devices)

By Applications: (Telemedicine, Caregiving Services, Medical Consultation, Others)

By End User: (Hospitals, Clinics, Others)

Regional Analysis for Market:

⇥ North America (U.S., Canada, Mexico)

⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)

⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)

⇥ South America (Colombia, Brazil, Argentina, Rest of South America)

⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)

Cross-Border E-Commerce Rules for Medical Devices in 2025

Regulatory frameworks vary by region but increasingly emphasize safety, traceability, and authorized seller identification.

Within the EU, online sales of medicines and devices require pharmacies to be authorized and display a national identification logo to verify legitimacy. Cross-border online sales are carefully regulated to ensure compliance with local laws, creating challenges for sellers operating from different EU countries without local authorization.​

China mandates filing and compliance with Good Supply Practice (GSP) for online sales, requiring distributors or platform providers to register with authorities and meet quality and security standards.​

India updated packaging and licensing regulations for medical devices sold online to ensure safety information, traceability, and consumer protection.​

The complexity of navigating multi-jurisdictional regulatory requirements leads sellers to adapt localized market strategies or partner with authorized distributors for compliance.

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How M&A Activity is Changing Healthcare Supply Chain Digitalization

M&A activity accelerates digital transformation by integrating new technologies into supply chain operations such as AI-driven predictive analytics, robotic process automation (RPA), cloud-based procure-to-pay (P2P) systems, and contract-to-cash automation.​

Acquiring companies with advanced digital platforms or incorporating digital healthcare solutions enables scalability, efficiency, and improved patient-centric supply chain models.​

Providers and suppliers increasingly focus on ecosystems integrating ERP, EHR, procurement, logistics, and accounts payable to create seamless data flow and reduce operational blind spots.​

AI and generative AI (GenAI) technologies are transitioning from experimentation to execution, with healthcare organizations prioritizing use cases delivering measurable value in supply chain resilience and cost optimization.​

M&A-related supply chain integration requires harmonizing IT infrastructures and stakeholder processes but also presents unique opportunities to modernize and digitize operations faster.

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