Press release
U.S. Liquid Biopsy Market to Reach USD 6.62 Billion by 2034, Growing at 13.55% CAGR
U.S. Liquid Biopsy Market
Liquid biopsy, a breakthrough diagnostic technique, enables the detection and monitoring of diseases such as cancer through a simple blood or fluid sample. By eliminating the need for tissue biopsies, it offers safer, faster, and cost-effective access to critical genetic insights for therapy decisions. As cancer rates increase and clinicians shift toward precision medicine, the U.S. market is witnessing rapid adoption of liquid biopsy assays across oncology and clinical research.
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Key Highlights from the Report
➤ The U.S. Liquid Biopsy Market is forecast to reach USD 6.62 billion by 2034, registering a 13.55% CAGR.
➤ Circulating Tumor Cells (CTC) biomarker segment will dominate market share between 2025 and 2034.
➤ Blood-based samples account for over 80% of total market applications for cancer monitoring.
➤ Cancer therapeutics represent the leading market application, supported by integrated genomic profiling.
➤ The lung cancer segment leads with 28.6% share, followed by pancreatic and CNS applications.
➤ Next-Generation Sequencing (NGS) technology retains the largest 42.1% market share due to superior genomic accuracy.
Market Segmentation
By Biomarker Type:
The Circulating Tumor Cells (CTC) segment dominates, enabling high-precision cancer detection from blood. RNA (microRNA, mRNA) biomarkers will grow steadily at a 9.20% CAGR, enhancing diagnosis accuracy and therapeutic monitoring through stabilized genetic analysis.
By Application:
Cancer therapeutics held the majority share in 2024 due to growing use in early diagnosis and treatment optimization. Therapy selection/companion diagnostics applications are expanding rapidly, with the FDA approving new co-developed diagnostic platforms for precision oncology treatments.
By Sample Type:
Blood samples accounted for over 81% share in 2024 and remain the most preferred sample type due to ease of collection and strong ctDNA yield. The cerebrospinal fluid (CSF) segment, critical for central nervous system tumor detection, is predicted to advance at a 9.40% CAGR through 2034.
By End User:
Hospitals and laboratories dominated the market in 2024 due to widespread adoption of clinical-grade liquid biopsy testing. Reference laboratories held a 39.7% revenue share, supported by partnerships among major laboratories such as Foundation Medicine and Guardant Health. Additionally, biopharmaceutical and biotechnology firms continue expanding investments in companion diagnostics and clinical trial collaborations.
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Regional Insights
The United States remains the global leader in liquid biopsy innovation and commercialization. Its dominance is supported by strong R&D infrastructure, early adoption of genomic technologies, and streamlined FDA regulatory pathways for diagnostic approvals. Rising cancer incidence-particularly lung, colorectal, and pancreatic cancers-is driving high utilization across healthcare facilities. Leading laboratories and biotech companies are developing next-generation liquid biopsy tests for early detection, minimal residual disease (MRD) monitoring, and treatment selection optimization.
Market Dynamics
Market Drivers:
Rapid growth in cancer incidence, coupled with demand for non-invasive diagnostic solutions, is propelling market expansion. Liquid biopsy's ability to detect tumor mutations, track therapy response, and guide precision medicine strategies makes it a critical advancement over traditional tissue biopsy methods.
Market Restraints:
Current challenges include reduced sensitivity in detecting ctDNA at very low concentrations, especially post-treatment, leading to potential false-negative results. Variability in test sensitivity continues to hinder consistent clinical adoption.
Market Opportunities:
The growing integration of companion diagnostics (CDx) with oncology drug development provides significant potential. Co-development of molecular assays alongside personalized therapies accelerates the approval process, improving treatment efficacy and commercialization outcomes.
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Reasons to Buy the Report
✔ Comprehensive analysis of the U.S. liquid biopsy market segmentation and emerging technologies.
✔ Detailed study of market drivers, restraints, and strategic growth opportunities through 2034.
✔ Insights on FDA-approved liquid biopsy tests and companion diagnostic collaborations.
✔ Coverage of competitive dynamics, mergers, and innovations transforming cancer diagnostics.
✔ Evaluation of investment prospects in precision oncology and personalized medicine.
Frequently Asked Questions (FAQs)
◆ How big is the U.S. Liquid Biopsy Market in 2024?
◆ What is the projected growth rate (CAGR) of the U.S. Liquid Biopsy Market through 2034?
◆ Which biomarker type holds the largest share in the liquid biopsy market?
◆ What cancers are primarily targeted through U.S. liquid biopsy diagnostics?
◆ Who are the key players leading the U.S. Liquid Biopsy Market?
Company Insights
Guardant Health, Inc.
Biocept, Inc.
Illumina, Inc.
Thermo Fisher Scientific, Inc.
Foundation Medicine, Inc.
Roche Diagnostics
Natera, Inc.
NeoGenomics Laboratories
GRAIL, Inc.
Exact Sciences Corporation
Recent Developments:
In July 2021, Biocept, Inc. secured a patent for its Primer-Switch technology enabling precise detection of rare ctDNA mutations via real-time PCR.
In February 2021, Guardant Health launched Guardant Reveal, the first blood-only liquid biopsy test for detecting residual and recurring disease through a single blood draw.
Conclusion
The U.S. Liquid Biopsy Market is entering a high-growth phase fueled by the rising prevalence of cancer and constant progress in molecular diagnostics. As clinical adoption surges, liquid biopsy is poised to transform early detection, residual disease monitoring, and precision treatment planning. With rapid advancements in genomic technologies and regulatory support for companion diagnostics, the market will continue driving innovation across oncology and personalized care segments through 2034.
Contact Us
Mr. Sai Kiran
DataM Intelligence 4market Research LLP Ground floor
DSL Abacus IT Park, Industrial Development Area
Uppal, Hyderabad, Telangana 500039
USA: +1 877-441-4866
Email: Sai.k@datamintelligence.com
Visit Our Website: https://www.datamintelligence.com
About Us
DataM Intelligence 4Market Research is a comprehensive market intelligence platform offering syndicated and customized reports along with expert consulting across multiple industries, including chemicals, healthcare, agriculture, food & beverages, and more. With extensive experience and a strategy-focused approach, DataM provides businesses and individuals with reliable market insights, statistical forecasts, and personalized research solutions to help them make informed decisions and successfully bring innovations to market.
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