Von Willebrand's Disease Pipeline 2025: Pioneering Clinical Developments by 4+ Global Leaders - DelveInsight | Highlighting Vega Therapeutics, Hemab

DelveInsight's, "Von Willebrand's Disease - Pipeline Insight, 2025" report provides comprehensive insights about 4+ companies and 4+ pipeline drugs in Von Willebrand's Disease pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
With Von Willebrand's Disease (VWD) increasingly prevalent worldwide and contributing to comorbidities such as diabetes, cardiovascular disease, and certain cancers, there is a rising demand for safer and more effective therapies. DelveInsight reports that more than four pharmaceutical and biotech companies are actively developing over 100 therapeutic candidates targeting VWD. These treatments are in various stages of clinical and preclinical development, reflecting significant innovation and a strong commitment to addressing this critical public health challenge.

DelveInsight's "Von Willebrand's Disease Pipeline Insight 2025" report offers a comprehensive and strategic review of the current R&D landscape. It details clinical trial progress, emerging therapies, mechanisms of action, competitive dynamics, and key company initiatives. The report is an essential resource for researchers, healthcare investors, and decision-makers seeking insights into the evolving VWD therapeutics market and the breakthroughs shaping its future.

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Key Takeaways from the Von Willebrand's Disease Pipeline Report

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DelveInsight's Von Willebrand's Disease (VWD) pipeline report highlights a dynamic landscape, with more than four companies actively developing multiple therapies for VWD treatment.

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In May 2025, the FDA accepted a priority review of Takeda's supplemental Biologics License Application (sBLA) for Vonvendi, the only recombinant VWF replacement, for routine prophylaxis in adults with Type 1 and Type 2 VWD, as well as for on-demand and perioperative use in children.

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Leading VWD-focused companies, including Vega Therapeutics, Hemab, and others, are actively evaluating new therapies to enhance treatment options. Promising candidates in the pipeline include VGA039 and several others, representing ongoing innovation in the field.

Von Willebrand's Disease Overview:

Von Willebrand disease (VWD) is the most common inherited bleeding disorder, caused by a deficiency or dysfunction of von Willebrand factor (VWF), a protein critical for normal blood clotting. This impairment affects platelet adhesion to blood vessel walls, increasing the risk of excessive or prolonged bleeding. VWD is typically inherited in an autosomal dominant manner and is classified into three main types-Type 1, Type 2, and Type 3-each varying in severity and symptom presentation. Common signs include frequent or prolonged nosebleeds, heavy bleeding from minor cuts, excessive menstrual bleeding, and extended bleeding after surgeries or dental procedures. While there is no cure for VWD, treatments such as desmopressin and clotting factor replacement therapies can effectively manage bleeding and allow patients to lead normal lives.

Symptoms can differ depending on the type and severity of VWD. Typical manifestations include easy bruising, nosebleeds lasting more than 10 minutes, heavy or prolonged menstrual periods, and extended bleeding following injury or medical procedures. In severe cases, such as Type 3 VWD, internal bleeding may lead to joint and muscle swelling, and some individuals may notice blood in their urine or stool or bleeding gums. Many people remain undiagnosed until a significant bleeding episode occurs.

Diagnosis involves a detailed review of the patient's bleeding history combined with specialized blood tests. Physicians assess the frequency and severity of bleeding events, including prolonged post-injury or post-surgical bleeding and unusually heavy menstrual flow. Laboratory tests generally measure VWF antigen levels, assess VWF function, and analyze factor VIII activity to classify the disease and guide treatment decisions.

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Von Willebrand's Disease Pipeline Analysis

The Von Willebrand's Disease pipeline insights report 2025, provides insights into:

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Provides comprehensive insights into key companies developing therapies in the Von Willebrand's Disease Market.

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Categorizes Von Willebrand's Disease therapeutic companies by development stage: early, mid, and late-stage.

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Highlights major companies involved in targeted therapy development, including both active and inactive (paused/discontinued) projects.

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Reviews emerging Von Willebrand's Disease drugs under development based on:

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Stage of development

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Von Willebrand's Disease Route of administration

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Target receptor

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Monotherapy vs. combination therapy

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Von Willebrand's Disease Mechanism of action

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Molecular type

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Offers detailed analysis of:

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Company-to-company and company-academia collaborations

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Von Willebrand's Disease Licensing agreements

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Funding and investment activities supporting future Von Willebrand's Disease market advancement.

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Von Willebrand's Disease Emerging Drugs

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VGA039: Star Therapeutics

VGA039 is an experimental monoclonal antibody therapy with a novel mechanism of action that targets Protein S, a key regulator of blood clotting. Developed as a potential broad-spectrum hemostatic treatment, its initial focus is on Von Willebrand Disease (VWD) but it may address other bleeding disorders in the future. Administered subcutaneously and designed for self-administration, VGA039 offers a convenient dosing schedule that could reduce the treatment burden for patients. The therapy is currently being evaluated in a Phase I/II clinical trial for VWD.

Von Willebrand's Disease Pipeline Therapeutic Assessment

Von Willebrand's Disease Assessment by Product Type

- Mono

- Combination

- Mono/Combination

Von Willebrand's Disease By Stage

- Late-stage products (Phase III)

- Mid-stage products (Phase II)

- Early-stage product (Phase I) along with the details of

- Pre-clinical and Discovery stage candidates

- Discontinued & Inactive candidates

Von Willebrand's Disease Assessment by Route of Administration

- Oral

- Parenteral

- Intravenous

- Subcutaneous

- Topical

Von Willebrand's Disease Assessment by Molecule Type

- Recombinant fusion proteins

- Small molecule

- Monoclonal antibody

- Peptide

- Polymer

- Gene therapy

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Table of Contents

1. Report Introduction

2. Executive Summary

3. Von Willebrand's Disease Current Treatment Patterns

4. Von Willebrand's Disease - DelveInsight's Analytical Perspective

5. Therapeutic Assessment

6. Von Willebrand's Disease Late-Stage Products (Phase-III)

7. Von Willebrand's Disease Mid-Stage Products (Phase-II)

8. Early Stage Products (Phase-I)

9. Pre-clinical Products and Discovery Stage Products

10. Inactive Products

11. Dormant Products

12. Von Willebrand's Disease Discontinued Products

13. Von Willebrand's Disease Product Profiles

14. Von Willebrand's Disease Key Companies

15. Von Willebrand's Disease Key Products

16. Dormant and Discontinued Products

17. Von Willebrand's Disease Unmet Needs

18. Von Willebrand's Disease Future Perspectives

19. Von Willebrand's Disease Analyst Review

20. Appendix

21. Report Methodology

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About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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