Mild Cognitive Impairment Market Analysis 2034 - Competitive Landscape, Clinical Trials, Market Share, Therapies, Prevalence, and Key Players by DelveInsight

Mild Cognitive Impairment companies include Alzheon Inc., AriBio Co., Ltd., Eli Lilly, Novo Nordisk, AgeneBio Inc., Anavex Life Sciences Corp., TauRx Therapeutics, Araclon Biotech S.L., AC Immune SA, Johnson & Johnson, and others.
Mild Cognitive Impairment Market Summary

The Mild Cognitive Impairment (MCI) market across the seven major markets (7MM) was valued at approximately USD 2.84 billion in 2023 and is expected to grow through 2034. The United States dominated the market with about USD 1.47 billion in 2023, the highest among all regions, and this figure is projected to rise further by 2034. Epidemiologically, the US also reported the largest share of prevalent MCI cases, accounting for 42% of total cases in the 7MM, followed by Japan at 27%, Germany at 10%, and France at 7%. In addition, around 6.98 million people in the US were affected by Alzheimer's disease in 2023, a number anticipated to increase by 2034. Germany recorded the highest diagnosed prevalence of MCI in Parkinson's disease among the EU4 and the UK, with nearly 223,000 cases, which are expected to grow over time. Japan also held a significant market position, generating nearly USD 670 million, or 24% of the 7MM market, in 2023, with further growth expected by 2034. Current treatment options include approved drugs like LEQEMBI (lecanemab) and off-label therapies such as cholinesterase inhibitors and memantine, contributing to USD 222 million of the market in 2023. The market outlook is further strengthened by the introduction of emerging therapies, including the July 2024 FDA approval of KISUNLA (donanemab) by Eli Lilly for early symptomatic Alzheimer's disease, which includes patients with Mild Cognitive Impairment.

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DelveInsight has introduced a new report titled "Mild Cognitive Impairment Market Insights, Epidemiology, and Market Forecast-2034," which offers a comprehensive analysis of Mild Cognitive Impairment, including past and projected epidemiology, along with market trends across the United States, the EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.

The Mild Cognitive Impairment (MCI) market report outlines current treatment approaches, upcoming therapies, and the market performance of individual treatments. It also examines the market size across the 7MM from 2020 to 2034, both currently and in forecasts.

New treatments for Mild Cognitive Impairment such as LEQEMBI (lecanemab), KISUNLA (donanemab), and others are expected to significantly contribute to market expansion in the coming years.

Some of the key facts of the Mild Cognitive Impairment Market Report:

* In 2023, the Mild Cognitive Impairment (MCI) market across the seven major markets (7MM) was valued at about USD 2.83 billion, with steady growth anticipated through 2034. The United States accounted for the largest share, generating nearly USD 1.47 billion in 2023, a figure expected to rise further over the forecast period.
* DelveInsight estimates that in 2023, the U.S. had approximately 1.21 million diagnosed cases of Parkinson's disease. Within Europe, Germany reported the highest number of Alzheimer's cases at around 1.49 million, followed by France with 1.17 million, while the UK had the lowest prevalence at 620,000. Germany also led the EU4 and the UK in diagnosed MCI cases associated with Parkinson's disease, recording nearly 223,000 cases in 2023, with numbers projected to increase by 2034. In the same year, the U.S. had the highest prevalence of Alzheimer's among the 7MM, with an estimated 6.98 million cases, and this burden is expected to continue rising.
* By share, the U.S. represented 42% of the MCI population across the 7MM, followed by Japan (27%), Germany (10%), and France (7%). Experts anticipate overall diagnosed cases to grow in the coming years. The current Mild Cognitive Impairment treatment landscape includes approved drugs such as LEQEMBI (lecanemab) alongside off-label use of cholinesterase inhibitors and memantine, contributing to a market value of about USD 222 million in 2023. Market expansion is expected as new therapies emerge between 2024 and 2034.
* A key milestone came in July 2024, when the U.S. FDA approved KISUNLA (donanemab-azbt, 350 mg/20 mL), developed by Eli Lilly, for the treatment of early symptomatic Alzheimer's disease, including MCI and mild dementia with confirmed amyloid pathology.
* Japan's Mild Cognitive Impairment market was valued at nearly USD 670 million in 2023, accounting for 24% of the 7MM market, and is also forecasted to grow by 2034.
* Several Mild Cognitive Impairment companies include Alzheon Inc., AriBio Co., Ltd., Eli Lilly, Novo Nordisk, AgeneBio Inc., Anavex Life Sciences Corp., TauRx Therapeutics, Araclon Biotech S.L., AC Immune SA, Johnson & Johnson, and others-are advancing new therapies to enhance the Mild Cognitive Impairment treatment landscape. Among the most promising pipeline candidates are LEQEMBI (lecanemab), KISUNLA (donanemab), and additional emerging therapies currently in development.
* In January 2023, the U.S. Food and Drug Administration (FDA) granted accelerated approval to Leqembi, developed by Eisai R&D Management Co., Ltd., for the treatment of Alzheimer's disease. The approval was based on the drug's demonstrated ability to reduce amyloid beta plaques, a key marker of Alzheimer's. It is indicated for patients in the early stages of the disease, including those with mild cognitive impairment or mild dementia.
* Meanwhile, Eli Lilly's Kisunla received approval from Japan's Ministry of Health, Labor, and Welfare for adults with early symptomatic Alzheimer's disease. Kisunla provides an option for early-stage patients, with the possibility of discontinuing treatment if amyloid levels drop below a defined threshold.

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Key benefits of the Mild Cognitive Impairment market report:

* Mild Cognitive Impairment market report covers a descriptive overview and comprehensive insight of the Mild Cognitive Impairment Epidemiology and Mild Cognitive Impairment market in the 7MM (the United States, EU5 (Germany, Spain, France, Italy, UK) & Japan.)
* The Mild Cognitive Impairment market report provides insights on the current and emerging therapies.
* Mild Cognitive Impairment market report provides a global historical and forecasted market covering drug outreach in 7MM.
* The Mild Cognitive Impairment market report offers an edge that will help in developing business strategies by understanding trends shaping and driving the Mild Cognitive Impairment market.

Mild Cognitive Impairment Overview

Mild Cognitive Impairment (MCI) represents a transitional phase between normal age-related cognitive changes and dementia, characterized by noticeable declines in memory, attention, and judgment that do not yet significantly interfere with daily functioning. Individuals with MCI face an elevated risk of progressing to Alzheimer's disease or other dementias.

As prevalence continues to rise, especially in older populations, the importance of early detection and targeted management strategies is growing.

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Mild Cognitive Impairment Market Outlook

Mild Cognitive Impairment (MCI) refers to a decline in cognitive abilities that exceeds typical aging but does not significantly disrupt daily functioning. Since MCI can progress to dementia, particularly Alzheimer's disease, early detection and intervention are critical. Management typically focuses on modifying risk factors such as diet, hypertension, and physical activity. While pharmacological options like cholinesterase inhibitors (ChEIs) and memantine are sometimes used, especially in Alzheimer's-related cases, non-drug strategies-including cognitive training, physical exercise, and lifestyle changes remain central to care.

Given the absence of standardized therapies, individualized treatment is important, especially for patients with coexisting conditions. Although ChEIs are frequently prescribed in Alzheimer's disease, their benefit in MCI is uncertain, often resulting in deprescribing. Agents like donepezil, rivastigmine, and galantamine provide only modest and temporary improvements, while memantine is better suited for moderate to severe cases.

With growing interest in advanced therapies, the MCI market is gaining momentum and opening avenues for innovation. Pipeline drugs such as Valiltramiprosate, Mirodenafil, and Hydromethylthionine mesylate (HMTM) hold potential to reshape market dynamics, though their long-term success remains to be determined.

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Mild Cognitive Impairment Epidemiology

DelveInsight's assessment shows that in 2023, the United States recorded approximately 1.21 million diagnosed prevalent cases of Parkinson's disease and nearly 4.22 million diagnosed cases of Mild Cognitive Impairment (MCI), the highest among the 7MM. In Europe, Germany had the largest number of diagnosed Alzheimer's cases at around 1.49 million, followed by France with about 1.17 million, while the UK had the lowest at 620,000. In Japan, there were roughly 2.73 million diagnosed Mild Cognitive Impairment cases, with 103,000 linked to Parkinson's disease and about 2.63 million due to Alzheimer's. By 2034, Alzheimer's-related Mild Cognitive Impairment in Japan is expected to rise further and continue to significantly outnumber Parkinson's-related Mild Cognitive Impairment. Projections also indicate that the UK is expected to lead in diagnosed Mild Cognitive Impairment cases by 2034.

Mild Cognitive Impairment Epidemiology Segmentation

* Total Diagnosed Prevalent Cases of Parkinson's Disease
* Total Diagnosed Prevalent Cases of Alzheimer's Disease
* Total Diagnosed Prevalent Cases of Mild Cognitive Impairment in the 7MM

Mild Cognitive Impairment Marketed Drugs

* LEQEMBI (lecanemab): Biogen Inc./Eisai Co., Ltd.
* KISUNLA (Donanemab): Eli Lilly and Company

Mild Cognitive Impairment Marketed Drugs

* Valiltramiprosate (ALZ-801): Alzheon Inc.
* Mirodenafil (AR1001): AriBio Co., Ltd.
* Hydromethylthionine Mesylate (HMTM)/TRx0237: TauRx Therapeutics

Scope of the Mild Cognitive Impairment Market Report

* Study Period: 2020-2034
* Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]
* Key Mild Cognitive Impairment Companies: Alzheon Inc., AriBio Co., Ltd., Eli Lilly, Novo Nordisk, AgeneBio, Inc., Anavex Life Sciences Corp., TauRx Therapeutics, Araclon Biotech S.L., AC Immune SA, Johnson & Johnson, and others
* Key Mild Cognitive Impairment Therapies: LEQEMBI (lecanemab), KISUNLA (Donanemab), and others
* Mild Cognitive Impairment Therapeutic Assessment: Mild Cognitive Impairment current marketed and Mild Cognitive Impairment emerging therapies
* Mild Cognitive Impairment Market Dynamics: Mild Cognitive Impairment market drivers and Mild Cognitive Impairment market barriers
* Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
* Mild Cognitive Impairment Unmet Needs, KOL's views, Analyst's views, Mild Cognitive Impairment Market Access and Reimbursement

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Table of Contents

1. Report Introduction

2. Executive Summary

3. SWOT analysis

4. Mild Cognitive Impairment Patient Share (%) Overview at a Glance

5. Mild Cognitive Impairment Market Overview at a Glance

6. Mild Cognitive Impairment Disease Background and Overview

7. Mild Cognitive Impairment Epidemiology and Patient Population

8. Country-Specific Patient Population of Mild Cognitive Impairment

9. Mild Cognitive Impairment Current Treatment and Medical Practices

10. Unmet Needs

11. Mild Cognitive Impairment Emerging Therapies

12. Mild Cognitive Impairment Market Outlook

13. Country-Wise Mild Cognitive Impairment Market Analysis (2020-2034)

14. Market Access and Reimbursement of Therapies

15. Market drivers

16. Market barriers

17. Appendix

18. Mild Cognitive Impairment Report Methodology

19. DelveInsight Capabilities

20. Disclaimer

21. About DelveInsight

About DelveInsight

DelveInsight is a leading business consulting and market research firm specializing in the life sciences sector. The company offers end-to-end market intelligence, including pipeline insights, epidemiology analysis, competitive intelligence, and portfolio strategy for global pharmaceutical and biotech firms.

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