Dry Eye Disease Pipeline Drugs Report 2025: Innovative Drug Developments and Ongoing Clinical Studies Uncovered

DelveInsight's "Dry Eye Disease Pipeline Insight 2025" report provides comprehensive insights about 50+ companies and 60+ pipeline drugs in the Dry Eye Disease pipeline landscape. It covers the Dry Eye Disease pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Dry Eye Disease pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the Dry Eye Disease Pipeline Report

* On 06 October 2025, Hoffmann-La Roche announced a study aims to evaluate the performance of biomarkers and their responsiveness to standard-of-care treatments (Vevye Registered or Xiidra Registered ), in participants with dry eye disease (DED) compared to healthy volunteers (control participants).
* On 03 October 2025, Dompe Farmaceutici S.p.A conducted a study is to evaluate the safety and efficacy of two different concentrations of the new formulation of rhNGF ophthalmic solution versus vehicle, in order to demonstrate superiority of at least one of the two concentrations over vehicle in the improvement of ocular symptoms of dry eye in participants with dry eye disease (DED). The rhNGF ophthalmic solution, or vehicle, will be administered as one drop in each eye, three times a day, for 4 weeks. Participants will attend a total of 5 study visits from screening through end of the study (Week 8), which will include eye exams and questionnaires.
* On 01 October 2025, Aldeyra Therapeutics Inc. organized a Phase 3 Vehicle-Controlled, Environment Exposure Clinical Trial to Assess the Efficacy and Safety of 0.25% Reproxalap Ophthalmic Solution Compared to Vehicle in Subjects With Dry Eye Disease
* DelveInsight's Dry Eye Disease pipeline report depicts a robust space with 50+ active players working to develop 60+ pipeline therapies for Dry Eye Disease treatment.
* The leading Dry Eye Disease Companies such as Alcon, Seikagaku Corporation, Huons, Aramis Biosciences, Invirsa, Inc., IVIEW Therapeutics, Seinda Pharmaceutical, Serentrix, EyeD Pharma, SELAGINE, Theratome Bio, Alchemedicine and others.
* Promising Dry Eye Disease Pipeline Therapies such as TJO-083, Diquafosol ophthalmic sodium solution 3%, VVN001 Ophthalmic Solution, 5%, ALY688 Ophthalmic Solution, INV-102, Brimonidine, SHJ002 and others.

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The Dry Eye Disease Pipeline Report provides a disease overview, pipeline scenario, and therapeutic assessment of the key pipeline therapies in this domain. The Dry Eye Disease Pipeline Report also highlights the unmet needs with respect to Dry Eye Disease.

Dry Eye Disease Overview

Dry Eye Disease (DED) is a common ocular condition characterized by insufficient tear production or poor tear quality, leading to discomfort, inflammation, and potential damage to the eye surface. It results from a disruption in the tear film, which can be caused by aging, environmental factors, autoimmune diseases, or prolonged screen time. Symptoms include dryness, burning, redness, blurred vision, and a sensation of grittiness in the eyes. If left untreated, DED can impact daily activities and reduce overall quality of life. With an increasing prevalence worldwide, ongoing research focuses on advanced therapies to improve tear stability and alleviate symptoms.

Dry Eye Disease Emerging Drugs Profile

* AR-15512: Alcon

AR-15512 is an investigational eye drop currently in clinical development at Aerie as a potential treatment for the signs and symptoms of dry eye disease. The active ingredient in AR-15512 is a proprietary small-molecule selective agonist of the transient receptor potential melastatin 8 (TRPM8) cold thermoreceptor, which represents a novel therapeutic target for dry eye. The drug is currently in Phase III stage of clinical trial evaluation for the treatment of DED.

* SI-614: Seikagaku Corporation

SI-614, an ophthalmic solution being developed by Seikagaku Corporation. CT-868 is a. SI-614 is an amphiphilic polymer produced by introducing a hydrophobic group into hyaluronic acid using Seikagaku's own proprietary technology. Ocular instillation of SI-614 in dry eye patients is thought to stabilize the tear film by utilizing the mucoadhesive and surface tension reducing properties of SI-614 and to promote corneal epithelial wound healing by binding SI-614 to the fibronectin that occurs on corneal epithelial defects to promote epithelial cell growth. Through these actions, SI-614 is expected to restore the tear film and corneal structure to their normal state and improve symptoms associated with dry eye. Currently, the drug is in the Phase III stage of development to treat Dry Eye Disease.

* HU007: Huons

HU007 is a combination of cyclosporine, an anti-inflammatory component, and trehalose, a tear film protection component, to minimize eye surface irritation such as burning sensation by lowering the concentration of cyclosporine to less than half than that of existing treatments. In addition, it is an ophthalmic agent developed to suppress the destruction of each conjunctival epithelial cells caused by drying by combining trehalose preparations and to see the combined treatment effect for dry eyes. Currently, the drug is in the Phase III stage of development to treat Dry Eye Disease.

* A197: Aramis Biosciences

A197 is a novel topical agent that targets the immunopathogenesis of dry eye disease. It has a unique mechanism of action compared to existing dry eye treatments. Currently, the drug is in the Phase II stage of development to treat Dry Eye Disease.

* INV 102: Invirsa, Inc.

INV 102 is an ophthalmic eye drop being developed by Invirsa, Inc. Invirsa's lead candidate is a naturally-occurring, small molecule that modulates the activity of p53, the central protein responsible for regulating the DNA damage response. Currently, the drug is in the Phase II stage of development to treat Dry Eye Disease.

* iVIEW 1001: IVIEW Therapeutics

iVIEW 1001 is a TRPM8 agonist drug being developed by iVIEW Therapeutics, Inc. to treat dry eye diseases. IVIEW 1001 is a TRPM8 agonist, which means it stimulates the transient receptor potential melastatin 8 (TRPM8) receptors in the eyelid margin. This stimulation sends a perception of coolness, reducing ocular discomfort and potentially increasing tear secretion. Currently, the drug is in the Phase I/II stage of development to treat Dry Eye Disease.

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The Dry Eye Disease Pipeline report provides insights into

* The report provides detailed insights about companies that are developing therapies for the treatment of Dry Eye Disease with aggregate therapies developed by each company for the same.
* It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Dry Eye Disease Treatment.
* Dry Eye Disease Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
* Dry Eye Disease Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
* Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Dry Eye Disease market.

Dry Eye Disease Companies

Alcon, Seikagaku Corporation, Huons, Aramis Biosciences, Invirsa, Inc., IVIEW Therapeutics, Seinda Pharmaceutical, Serentrix, EyeD Pharma, SELAGINE, Theratome Bio, Alchemedicine and others.

Dry Eye Disease pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

* Oral
* Intravenous
* Subcutaneous
* Parenteral
* Topical

Dry Eye Disease Products have been categorized under various Molecule types such as

* Recombinant fusion proteins
* Small molecule
* Monoclonal antibody
* Peptide
* Polymer
* Gene therapy

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Scope of the Dry Eye Disease Pipeline Report

* Coverage- Global
* Dry Eye Disease Companies- Alcon, Seikagaku Corporation, Huons, Aramis Biosciences, Invirsa, Inc., IVIEW Therapeutics, Seinda Pharmaceutical, Serentrix, EyeD Pharma, SELAGINE, Theratome Bio, Alchemedicine and others.
* Dry Eye Disease Pipeline Therapies- TJO-083, Diquafosol ophthalmic sodium solution 3%, VVN001 Ophthalmic Solution, 5%, ALY688 Ophthalmic Solution, INV-102, Brimonidine, SHJ002, and others.
* Dry Eye Disease Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
* Dry Eye Disease Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

For a detailed overview of our latest research findings and future plans, read the full details of Dry Eye Disease Pipeline on our website @ Dry Eye Disease Emerging Drugs and Companies [https://www.delveinsight.com/sample-request/dry-eye-disease-pipeline-insight?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr]

Table of Contents

* Introduction
* Executive Summary
* Dry Eye Disease: Overview
* Pipeline Therapeutics
* Therapeutic Assessment
* Dry Eye Disease- DelveInsight's Analytical Perspective
* Late Stage Products (Phase III)
* AR-15512: Alcon
* Drug profiles in the detailed report.....
* Mid Stage Products (Phase II)
* INV 102: Invirsa, Inc.
* Drug profiles in the detailed report.....
* Early Stage Products (Phase I/II)
* iVIEW 1001: IVIEW Therapeutics
* Drug profiles in the detailed report.....
* Preclinical and Discovery Stage Products
* Drug name: Company name
* Drug profiles in the detailed report.....
* Inactive Products
* Dry Eye Disease Key Companies
* Dry Eye Disease Key Products
* Dry Eye Disease- Unmet Needs
* Dry Eye Disease- Market Drivers and Barriers
* Dry Eye Disease- Future Perspectives and Conclusion
* Dry Eye Disease Analyst Views
* Dry Eye Disease Key Companies
* Appendix

About Us

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