Press release
Anti-inflammatory Drugs Market Size to Reach US$ 198.92 Billion by 2031, Growing at 8.7% CAGR
The global anti-inflammatory drugs market reached US$ 102.72 billion in 2023 and is projected to climb to US$ 198.92 billion by 2031, expanding at a compound annual growth rate (CAGR) of 8.7% between 2024 and 2031. The increasing prevalence of chronic and autoimmune diseases such as arthritis, inflammatory bowel disease (IBD), asthma, and chronic obstructive pulmonary disease (COPD), combined with ongoing advancements in drug innovation, continues to drive market growth.Anti-inflammatory drugs reduce inflammation by targeting mediators including prostaglandins, cytokines, and leukotrienes. As global populations age and chronic disease burdens rise, these drugs remain a cornerstone of treatment. According to the CDC (June 2024), arthritis alone is projected to affect around 78 million adults in the U.S. by 2040, representing a major catalyst for demand.
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Market Drivers and Restraints
Rising Prevalence of Inflammatory Disorders Boosts Demand
The growing incidence of chronic inflammatory and autoimmune conditions is a key market driver. Rheumatoid arthritis, IBD, and psoriasis are increasingly widespread globally, especially among aging populations. In April 2024, an NCBI report estimated that rheumatoid arthritis affects roughly 1.3 million adults in the U.S., with IBD incidence rising by 5.2% annually among senior populations.
Pharmaceutical innovation and new drug formulations also play pivotal roles. For instance, a 2023 initiative by India's Ministry of Science & Technology introduced a system combining anti-inflammatory agents with advanced delivery methods for improved therapeutic targeting. Likewise, breakthroughs in biologics and biosimilars that act on specific inflammatory pathways are enhancing efficacy and safety profiles, extending market growth opportunities.
Side Effects Impeding Broader Adoption
Despite their effectiveness, many anti-inflammatory drugs-particularly NSAIDs and corticosteroids-carry adverse effects that can limit usage. According to a 2023 NCBI article, NSAIDs may cause gastrointestinal, renal, cardiovascular, hepatic, and hematologic complications, in addition to allergic and respiratory reactions. These challenges underscore the growing importance of precision therapies, biologics, and safer delivery systems to maintain adherence and minimize risks.
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Market Segmentation
By Drug Class
Nonsteroidal Anti-inflammatory Drugs (NSAIDs) remain the dominant drug class segment, long relied upon for pain and inflammation management across multiple conditions. They act by inhibiting cyclooxygenase (COX) enzymes responsible for prostaglandin synthesis. Widely used NSAIDs include ibuprofen, naproxen, and diclofenac.
Recent approvals further reinforce segment expansion. In July 2024, ANI Pharmaceuticals gained FDA approval for a delayed-release naproxen formulation to treat arthritis and inflammatory pain. Similarly, Strides Pharma received approval for 220 mg naproxen sodium soft gel capsules in 2022, offering affordable, over-the-counter options.
Biologics Segment Experiencing Fastest Growth
Biologics represent the fastest-growing drug class, revolutionizing inflammatory disease treatment through targeted action on molecules such as cytokines. Unlike conventional anti-inflammatories, biologics deliver precision therapy with reduced off-target effects. Rising incidences of autoimmune conditions such as rheumatoid arthritis and IBD are amplifying demand for biologics and biosimilars.
By Application
Arthritis Segment Holds Largest Share
Arthritis remains the largest application segment in the anti-inflammatory drugs market. Joint inflammation, stiffness, and chronic pain continue to affect a significant portion of the global population. As per CDC data (March 2024), arthritis impacts about 54 million Americans-one in four adults-making it a top driver of drug demand.
Therapeutic innovations, including biologics and disease-modifying antirheumatic drugs (DMARDs), have improved management and patient outcomes, accelerating adoption. The increasing prevalence of osteoarthritis and rheumatoid arthritis, linked to aging and obesity trends, further boosts ongoing market expansion.
COPD Segment Exhibiting Fastest Growth
COPD is the fastest-growing application segment. The World Health Organization (November 2024) reported COPD as the fourth leading global cause of death, responsible for 3.5 million deaths in 2021. Bronchodilators, corticosteroids, and PDE4 inhibitors remain central to treatment, while combination therapies are delivering improved outcomes.
Regional variations in risk factors-tobacco use in developed nations and indoor pollution in low- and middle-income countries-underscore the global scale of demand for anti-inflammatory therapies in respiratory diseases.
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Regional Insights
North America: Market Leader with Strong Research Backbone
North America dominates the global market, supported by widespread chronic disease prevalence, robust healthcare systems, and the presence of leading pharmaceutical companies. Rising cases of arthritis, psoriasis, and IBD continue to bolster demand for advanced anti-inflammatory therapies.
Collaborative research and FDA drug approvals enhance the region's market strength. In April 2024, Glenmark Pharmaceuticals secured FDA approval for acetaminophen-ibuprofen combination tablets (250 mg/125 mg). Similarly, collaborative research between the Hudson Institute of Medical Research and Adiso Therapeutics is advancing inflammasome-targeted drug development.
Asia Pacific: Fastest-Growing Region
Asia Pacific is anticipated to register the fastest market growth through 2031. The region's expanding elderly population, higher rates of COPD and IBD, and increasing awareness of chronic inflammatory diseases support strong demand. Governments and pharmaceutical companies are also advancing R&D and improving accessibility to innovative biologic drugs.
Key contributors such as China, Japan, and India are improving healthcare infrastructure and accelerating approvals for novel anti-inflammatory treatments.
Competitive Landscape
Major market players driving innovation include:
AbbVie Inc.
Johnson & Johnson Services, Inc.
Pfizer Inc.
F. Hoffmann-La Roche Ltd
AstraZeneca
Novartis AG
Amgen Inc.
GSK plc
Merck & Co., Inc.
Bristol-Myers Squibb Company
Viatris Inc.
Emerging players such as UCB S.A., Rapport Therapeutics, and Apogee Therapeutics, Inc. are strengthening market competitiveness through next-generation biologics and advanced delivery mechanisms.
Key Developments
July 2024: Hikma Pharmaceuticals PLC received a permanent HCPCS J-code from CMS for COMBOGESIC IV, a combination analgesic of acetaminophen and ibuprofen for adult pain management.
July 2024: Alembic Pharmaceuticals obtained FDA approval for Bremen Ophthalmic Solution (0.07%), an NSAID indicated for post-cataract inflammation and ocular pain.
March 2024: Endo International plc launched Ibuprofen-Famotidine 800 mg/26.6 mg tablets, providing effective pain relief while reducing gastrointestinal risks associated with traditional NSAIDs.
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DataM Intelligence 4Market Research is a comprehensive market intelligence platform offering syndicated and customized reports along with expert consulting across multiple industries, including chemicals, healthcare, agriculture, food & beverages, and more. With extensive experience and a strategy-focused approach, DataM provides businesses and individuals with reliable market insights, statistical forecasts, and personalized research solutions to help them make informed decisions and successfully bring innovations to market.
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