Press release
United States Treatment-Resistant Depression (TRD) Market Boom | Top Companies, New Therapies & Future Forecast 2025
Treatment-Resistant Depression (TRD) Market
Mergers & Acquisitions
The TRD market is experiencing active M&A, with pharmaceutical companies acquiring or partnering to access promising novel therapies targeting resistant depression pathways.
Key players like Janssen, AbbVie, and Johnson & Johnson continue expanding their neuroscience portfolios through technology and drug candidate acquisitions.
On January 30, 2023, Rexulti (brexpiprazole) received a new approval in Japan for treating depression in patients unresponsive to prior antidepressant therapy. A Phase 3 trial involving 740 adults with MDD, aged 20-64, evaluated the safety and efficacy of brexpiprazole as an adjunct therapy.
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FDA Approvals
In July 2025, Johnson & Johnson's SPRAVATO® (esketamine) nasal spray received FDA approval as the first and only monotherapy for adults with TRD, allowing use without concurrent oral antidepressants.
This approval followed Priority Review and was based on demonstrating rapid symptom relief and improved remission rates versus placebo within four weeks
List of Top Key Players:
Pfizer Inc., Viatris Inc., Novartis AG, AbbVie Inc., Eli Lilly and Company, Otsuka America Pharmaceutical, Inc., AstraZeneca, Camber Pharmaceuticals, Inc., Biodesix and Validus Pharmaceuticals LLC.
Forecast Growth Projection:
Global Treatment-Resistant Depression Market Positioned for Strong Growth 2025-2032, Building on the steady momentum of 2024, the market is poised for remarkable expansion as leading players embrace innovative technologies and strategic advancements. This evolving landscape is unlocking lucrative opportunities for businesses to invest, scale, and stay ahead in an increasingly competitive and fast-moving market.
Market Research Process:
The Treatment-Resistant Depression Market research report by DataM Intelligence combines extensive Primary and Secondary research to provide powerful, in-depth insights. It examines key market drivers such as regulatory frameworks, evolving market conditions, competitive dynamics, historical trends, and breakthrough technologies, while spotlighting emerging innovations and potential challenges. This all-inclusive analysis uncovers high-growth opportunities and highlights possible barriers, equipping businesses to tackle market volatility and capture new avenues for success.
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Clinical Trials
Ongoing and upcoming trials explore psychedelics like psilocybin and ketamine derivatives, as well as next-gen pharmacotherapies targeting synaptic plasticity and glutamate signaling.
Trials also assess combination therapies and personalized medicine approaches leveraging biomarkers to optimize treatment response in TRD populations.
Market Segments:
By Drugs: Antipsychotics (Aripiprazole (Abilify), Brexpiprazole (Rexulti), Quetiapine (Seroquel), Olanzapine (Zyprexa)), Selective Serotonin Reuptake Inhibitors (SSRIs) (Fluoxetine (Prozac), Sertraline (Zoloft), Citalopram (Celexa), Paroxetine (Paxil)), Serotonin and Noradrenaline Reuptake Inhibitors (SNRIs) (Duloxetine (Cymbalta), Venlafaxine (Effexor XR), Desvenlafaxine (Pristiq)), Monoamine Oxidase Inhibitors (MAOIs) (Phenelzine (Nardil), Isocarboxazid (Marplan)), Others
By Route of Administration: Oral, Injectable, Others
By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies
Global Growth Regions:
⇥ North America (U.S., Canada, Mexico)
⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)
⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)
⇥ South America (Colombia, Brazil, Argentina, Rest of South America)
⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)
Benefits of the Report:
Chapter 1: Opens the report with a comprehensive market overview, highlighting key segments by region, product type, and application. It presents a clear snapshot of market size, growth potential by segment, and both short- and long-term outlook.
Chapter 2: Showcases the most impactful insights, uncovering the emerging trends and disruptive forces shaping the industry's future.
Chapter 3: Delivers an in-depth competitive landscape analysis of the Treatment-Resistant Depression market, covering revenue shares, strategic moves, and the latest mergers & acquisitions.
Chapter 4: Features detailed profiles of leading players, including their revenue streams, profit margins, product portfolios, and key milestones.
Chapters 5 & 6: Present a granular breakdown of regional and country-level revenue performance, offering a precise view of market size, opportunities, and development prospects worldwide.
Chapter 7: Analyzes market segmentation by product type, revealing the growth potential of each category and spotlighting high-impact.
Chapter 8: Examines application-based market growth, identifying the fastest-expanding sectors and lucrative opportunities for expansion.
Chapter 9: Maps the entire industry supply chain, providing insights into upstream and downstream activities for a complete market perspective.
Chapter 10: Concludes with key findings and actionable takeaways, guiding stakeholders toward strategic decisions and future growth opportunities.
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FAQ's
Q: Which Region Leads Treatment-Resistant Depression Market growth?
A: North America held approximately 41% of the market share in 2023.
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