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Growth Of The Biopharmaceutical Sector Driving Demand For In DNA And RNA Synthesis: The Driving Engine Behind Phosphoramidite Market Evolution in 2025
Use code ONLINE30 to get 30% off on global market reports and stay ahead of tariff changes, macro trends, and global economic shifts.Phosphoramidite Market Size Growth Forecast: What to Expect by 2025?
Over the past few years, the phosphoramidite market has seen significant growth. The global market is projected to increase from a size of $1.01 billion in 2024 to $1.07 billion in 2025, with a compound annual growth rate (CAGR) of 6.1%. This substantial growth during the historic period is primarily due to factors such as the heightened demand for DNA and RNA synthesis, an increase in the use of mRNA-based therapeutics, a rise in genetic disorders, escalating demand for synthetic biology, and a surge in investment towards genomic research.
How Will the Phosphoramidite Market Size Evolve and Grow by 2029?
In the upcoming years, a robust expansion is anticipated for the phosphoramidite market, with projections indicating a growth to $1.4 billion in 2029, and a compound annual growth rate (CAGR) of 7.0%. This expected rise over the forecast period can be linked to the increased use of phosphoramidites, a surge in the demand for custom DNA and RNA synthesis, an escalating requirement for high-purity phosphoramidites, a growing emphasis on individualized medicine, and an increase in biopharmaceutical firms. Future trends include the growth of synthetic biology, the invention of new phosphoramidite chemical procedures, genomic technology advancements, activities geared towards biotechnology development, and the evolution of personalized medicine.
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What Drivers Are Propelling the Growth of Phosphoramidite Market Forward?
Progress in the biopharmaceutical field is projected to spur the growth of the phosphoramidite market. The biopharmaceutical sector encompasses industries engaged in the research, development, manufacturing, and sale of medicinal products derived from biological sources, encompassing vaccines, gene therapies, monoclonal antibodies, and recombinant proteins. The sector's growth is due to advancements in biotechnology, the rising incidence of chronic diseases, and an increase in research and development investment. Emerging biotechnological techniques, like gene editing and monoclonal antibody treatments, have resulted in more effective, targeted therapies. The phosphoramidite market will be boosted by the growth of the biopharmaceutical industry, as phosphoramidites are critical in constructing DNA and RNA for gene therapies, mRNA vaccines, and oligonucleotide-based drugs. With the growing popularity of these treatments, phosphoramidites' role in creating synthetic nucleic acids will increase, augmenting their application in biopharmaceutical research and manufacturing. For instance, the core biopharmaceutical sector, according to the UK government, earned £46.7 ($58.4 billion) billion in 2022, accounting for 43% of the total turnover of the life sciences sector. The sector contributes to over 126,000 jobs and has seen significant growth in research and development funding. As a result, the increasing expansion of the biopharmaceutical sector is propelling the growth of the phosphoramidite market.
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What Are the Key Trends Driving Phosphoramidite Market Growth?
The key players in the phosphoramidite industry are prioritizing the creation of advanced DNA synthesis services. Their goal is to boost precision, speed, and environmental-friendliness and minimize the production of harmful waste during DNA manufacturing. DNA synthesis, which involves the creation of DNA sequences using enzymes instead of chemical reagents, promises greater speed, precision, and sustainability. In an example from April 2022, Ansa Biotechnologies Inc., a biotechnology firm based in the US, confirmed the completion of a heavily subscribed $68 million Series A funding round, spearheaded by Northpond Ventures. Numerous new and old investors joined the round. The fund's purpose is to hasten the progress of Ansa's state-of-the-art enzymatic DNA synthesis technology, otherwise known as phosphoramidite synthesis. It will also aid in the expansion of the company's research and development and manufacturing facilities and the launch of a modifiable DNA synthesis service. This company, which branched out from the University of California, Berkeley, employs a proprietary method that facilitates quick and accurate synthesis of extensive DNA sequences, thereby tackling existing industry challenges.
What Are the Key Segments in the Phosphoramidite Market?
The phosphoramidite market covered in this report is segmented -
1) By Type: Deoxyribonucleic Acid (DNA) Phosphoramidites, Ribonucleic Acid (RNA) Phosphoramidites, Labeled Phosphoramidites, Modifier Phosphoramidites, Other Types
2) By Synthesis Method: H-Phosphonate Method, Phosphoramidite Method, Trivalent Phosphorus Compounds Method
3) By Application: Gene Synthesis, Deoxyribonucleic Acid (DNA) Sequencing, Deoxyribonucleic Acid (DNA) Amplification
4) By End-User: Academic Research, Pharmaceutical Industry, Biotechnology Industry
Subsegments:
1) By Deoxyribonucleic Acid (DNA) Phosphoramidites: Standard DNA Phosphoramidites, Degenerate DNA Phosphoramidites, Methylated DNA Phosphoramidites, Backbone-Modified DNA Phosphoramidites
2) By Ribonucleic Acid (RNA) Phosphoramidites: Standard RNA Phosphoramidites, 2'-O-Methyl RNA Phosphoramidites, 2'-Fluoro RNA Phosphoramidites, 2'-O-TBDMS Protected RNA Phosphoramidites
3) By Labeled Phosphoramidites: Fluorescent-Labeled Phosphoramidites, Biotin-Labeled Phosphoramidites, Digoxigenin-Labeled Phosphoramidites, Radioisotope-Labeled Phosphoramidites
4) By Modifier Phosphoramidites: Amine-Modified Phosphoramidites, Thiol-Modified Phosphoramidites, Spacer Phosphoramidites, Azide-Modified Phosphoramidites
5) By Other Types: Chimeric Phosphoramidites, Phosphorothioate Phosphoramidites, PEGylated Phosphoramidites, Photo-Cleavable Phosphoramidites
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Who Are the Key Players Shaping the Phosphoramidite Market's Competitive Landscape?
Major companies operating in the phosphoramidite market are Thermo Fisher Scientific Inc., Agilent Technologies Inc., Aragen Life Sciences, Twist Bioscience, Innovassynth Technologies (I) Ltd., Tokyo Chemical Industry Co. Ltd. (TCI), Aurigene Services, Eurofins Genomics, LGC Biosearch Technologies, Link Technologies Ltd., Creative Biolabs, Biosynth Carbosynth, TriLink BioTechnologies, ChemGenes Corporation, Berry & Associates Inc., Lumiprobe Corporation, Hongene Biotech Corporation, Carbolink India Pvt. Ltd., PolyOrg Inc., Glen Research, Gene Link Inc., emp BIOTECH GmbH
What Geographic Markets Are Powering Growth in the Phosphoramidite Market?
North America was the largest region in the phosphoramidite market in 2024. Europe is expected to be the fastest-growing region during the forecast period. The regions covered in the phosphoramidite market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
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