Enzyme Replacement Therapy Market Set To Surge Due To Escalating Prevalence Of Chronic And Inherited Disorders: The Driving Engine Behind Enzyme Replacement Therapy Market Evolution in 2025

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Enzyme Replacement Therapy Market Size Growth Forecast: What to Expect by 2025?
In the recent past, there has been substantial growth in the market size of enzyme replacement therapy. The market value is projected to rise from $11.58 billion in 2024 to $12.36 billion in 2025, reflecting a compound annual growth rate (CAGR) of 6.7%. This incremental growth in the historic period can be credited to factors such as improved therapeutic discoveries, breakthroughs in treatment approvals, enhanced understanding of diseases, successful clinical outcomes, as well as regulatory backing and incentives.

How Will the Enzyme Replacement Therapy Market Size Evolve and Grow by 2029?
The market for enzyme replacement therapy is predicted to undergo significant expansion in the coming years, with an anticipated worth of $17.48 billion by 2029, growing at a compound annual growth rate of 9.0%. Factors contributing to this expansion during the forecast period include improved patient access to healthcare, customised treatments and individualised medicine, alterations in the regulatory landscape, and increased awareness among the patient population. Key trends to expect during the forecast period are the incorporation of digital health, patient-oriented solutions, advancements in biomarker studies, and the application of precision medicine.

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What Drivers Are Propelling the Growth of Enzyme Replacement Therapy Market Forward?
The expanding frequency of rare, chronic, and inherited disorders is likely to spur the expansion of the enzyme replacement therapy market in the future. Usually, chronic illnesses last for over three months and can deteriorate over time. They are more prevalent in older individuals and can typically be managed but not entirely eliminated. For example, data from the American Lung Association, a non-profit organization based in the US, reported that in July 2024, 44.2 million Americans, representing 13.5% of the population, were diagnosed with asthma by a healthcare professional. This was a rise from the 12.9% recorded in 2021. Thus, the increasing frequency of rare, chronic, and inherited diseases will stimulate the growth of the enzyme replacement therapy market.

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What Are the Key Trends Driving Enzyme Replacement Therapy Market Growth?
The enzyme replacement therapy market is witnessing a surge in popularity due to a trend of product approvals. Numerous enzyme replacement therapy drugs from major players are gaining market authorization. For example, in February 2023, Lamzede (velmanase alfa) received approval from the Food and Drug Administration, a US-based federal agency within the Department of Health. This marked the first enzyme replacement therapy in the United States to secure approval for the treatment of non-central neurological indications of alpha-mannosidosis; a rare genetic disorder where the body lacks the alpha-mannosidase enzyme. Lamzede, by mimicking the alpha-mannosidase enzyme, enables patients to restore normal cell function, thus enhancing their health. Patients receive Lamzede as a 10mg injection once a week.

What Are the Key Segments in the Enzyme Replacement Therapy Market?
The enzyme replacement therapy market covered in this report is segmented -

1) By Enzyme Type: Agalsidase Alfa, Agalsidase Beta, Galsulfase, Other Enzyme Types
2) By Route Of Administration: Oral, Parenteral
3) By Application: Gaucher Disease, Pompe Disease, Fabry Disease, Other Applications
4) By End-Users: Hospitals, Infusion Centers, Other End-Users

Subsegments:
1) By Agalsidase Alfa: Fabry Disease Treatment
2) By Agalsidase Beta: Fabry Disease Treatment
3) By Galsulfase: Mucopolysaccharidosis VI (MPS VI) Treatment
4) By Other Enzyme Types: Alglucosidase Alfa, Idursulfase, Velaglucerase Alfa

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Who Are the Key Players Shaping the Enzyme Replacement Therapy Market's Competitive Landscape?
Major companies operating in the enzyme replacement therapy market include Biomarin Pharmaceutical Inc., Leadiant Biosciences Inc., Pfizer Inc., Sanofi S.A., AbbVie Inc., Johnson & Johnson Services Inc., Alexion Pharmaceuticals Inc., Recordati Rare Diseases Inc., Sangamo Therapeutics Inc., JCR Pharmaceuticals Co. Ltd., Horizon Pharma Public Limited Company, Protalix Biotherapeutics Ltd., Amicus Therapeutics Inc., AstraZeneca plc, Novartis AG, Roche Holding AG, GlaxoSmithKline plc, Merck & Co. Inc., Eli Lilly and Company, Bristol-Myers Squibb Company, Retrophin Inc., Abeona Therapeutics Inc., Orchard Therapeutics plc, Ultragenyx Pharmaceutical Inc.

What Geographic Markets Are Powering Growth in the Enzyme Replacement Therapy Market?
North America was the largest region in the enzyme replacement therapy market in 2024.Asia-Pacific is expected to be the fastest-growing region in the global enzyme replacement therapy market report during the forecast period. The regions covered in the enzyme replacement therapy market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa

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