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Parkinson's Disease-Related Dementia (PDD) Market to Reach USD 7.9 Billion by 2034

09-11-2025 02:55 PM CET | Health & Medicine

Press release from: Exactitude Consultancy

Parkinson's Disease-Related Dementia

Parkinson's Disease-Related Dementia

Parkinson's Disease-Related Dementia (PDD) is a progressive neurocognitive disorder that develops in patients with long-standing Parkinson's disease (PD). It is characterized by cognitive decline, memory impairment, visual hallucinations, fluctuating attention, and executive dysfunction, in addition to the motor symptoms of PD.

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Up to 75% of PD patients eventually develop dementia, making PDD a significant public health challenge. The market is shaped by rising aging populations, drug innovations, and improved diagnostic tools, alongside non-drug interventions and caregiver-support models.

Market Overview
• Market Size (2024): USD 4.3 billion
• Forecast (2034): USD 7.9 billion
• CAGR (2025-2034): 6.2%

Growth is fueled by rising PD prevalence, better recognition of cognitive decline, and drug pipeline development targeting alpha-synuclein and neurotransmitter systems.

Key Highlights:
• PDD affects an estimated 5-8 million people globally.
• Cholinesterase inhibitors (rivastigmine, donepezil) remain primary symptomatic treatments.
• Digital cognitive testing and biomarker research are improving early diagnosis.
• Caregiver burden and healthcare costs remain critical challenges.

Segmentation Analysis
By Product Type:
• Pharmacological Therapies
o Cholinesterase Inhibitors (Rivastigmine - FDA approved for PDD, Donepezil)
o NMDA Receptor Antagonists (Memantine - off-label)
o Antipsychotics (Quetiapine, Clozapine for hallucinations; Pimavanserin - FDA approved for PD psychosis)
o Pipeline Agents (alpha-synuclein-targeting therapies, neuroprotective agents)

• Non-Pharmacological Interventions
o Cognitive Behavioral Therapy (CBT)
o Physical & Occupational Therapy
o Lifestyle & Caregiver Support Programs

• Diagnostics & Digital Tools
o Biomarker-Based Tests (CSF, blood-based alpha-synuclein markers)
o AI-Powered Cognitive Assessments
o Imaging (MRI, PET)

By Platform:
• Small Molecules (rivastigmine, memantine)
• Biologics (monoclonals targeting alpha-synuclein, research stage)
• Digital Tools & Cognitive Platforms

By Technology:
• AI-Based Cognitive Testing
• Biomarker Discovery for Early PDD
• Digital Therapeutics

By End Use:
• Hospitals & Neurology Clinics
• Memory Care Centers
• Home Care Settings
• Research Institutes

By Application:
• Early Cognitive Decline in PD
• Moderate-to-Severe PDD
• Clinical Research

Segmentation Summary:
Pharmacological treatments dominate today, but biologics, digital cognitive tools, and caregiver support programs are emerging as high-growth areas.

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Regional Analysis
North America
• ~44% share in 2024.
• Strong adoption of rivastigmine and Pimavanserin.
• FDA approvals and advanced dementia care infrastructure driving growth.
Europe
• ~29% share.
• Germany, UK, and France leading in integrated dementia and Parkinson's care.
• EMA pipeline reviews expanding drug access.
Asia-Pacific
• Fastest-growing region with CAGR of ~7.4%.
• Rising PD prevalence in Japan, China, and India.
• Growing dementia awareness and diagnostic infrastructure.
Middle East & Africa
• Smaller market but increasing with aging demographics.
• Limited specialized dementia care facilities.
Latin America
• Brazil and Mexico driving regional adoption.
• Expanding memory care and neurology access.
Regional Summary:
North America and Europe dominate today's market, while Asia-Pacific grows fastest due to rising prevalence, healthcare investment, and expanding memory care infrastructure.

Market Dynamics
Key Growth Drivers:
• Rising global PD prevalence and aging populations.
• Increasing recognition and diagnosis of cognitive decline in PD.
• Pipeline therapies targeting alpha-synuclein and neuroprotection.
• Expanding digital diagnostics and caregiver support solutions.

Key Challenges:
• Lack of disease-modifying therapies.
• High caregiver and healthcare burden.
• Underdiagnosis of early cognitive decline.
• Limited infrastructure in low-income regions.

Latest Trends:
• Alpha-synuclein-targeting biologics under clinical trials.
• AI-driven neurocognitive testing for early detection.
• Digital caregiver support and remote monitoring solutions.
• Multimodal care models combining drugs, therapy, and digital health.

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Competitor Analysis
Major Players in the Market:
• Novartis AG (Rivastigmine - Exelon)
• Eisai Co., Ltd. (Donepezil - with Pfizer Inc.)
• ACADIA Pharmaceuticals Inc. (Pimavanserin - Nuplazid)
• Johnson & Johnson
• GlaxoSmithKline plc
• Eli Lilly and Company (neurodegenerative R&D pipeline)
• Biogen Inc.
• Roche Holding AG (biomarker research, pipeline therapies)
• AbbVie Inc.
• Cogstate Ltd. (digital cognitive assessment tools)

Competitive Summary:
Novartis leads with rivastigmine, while ACADIA dominates PD psychosis treatment with Pimavanserin. Eisai and Pfizer maintain donepezil presence, while Biogen, Roche, and Eli Lilly lead neurodegenerative R&D. Cogstate and other digital firms innovate in cognitive diagnostics. Competition centers on pipeline therapies, biomarker diagnostics, and digital health integration.

Conclusion
The Parkinson's Disease-Related Dementia (PDD) Market, valued at USD 4.3 billion in 2024, is projected to reach USD 7.9 billion by 2034, growing at a CAGR of 6.2%. Expanding diagnosis, symptomatic drug adoption, and biomarker-driven research will continue to shape the market.

Key Takeaways:
• Cholinesterase inhibitors remain standard, with Pimavanserin expanding use.
• North America and Europe dominate, while Asia-Pacific grows fastest.
• Biomarkers and AI-based diagnostics are transforming early detection.
• Multimodal care models integrating drugs, therapy, and digital health will define the future.

The next decade will transform PDD management from symptomatic-only approaches to precision-driven, biomarker-guided, and digitally integrated dementia care, creating strong opportunities for pharma, biotech, and digital health innovators.

This report is also available in the following languages : Japanese (パーキンソン病関連認知症市場), Korean (파킨슨병 관련 치매 시장), Chinese (帕金森病相关痴呆症市场), French (Marché de la démence liée à la maladie de Parkinson), German (Markt für Parkinson-bedingte Demenz), and Italian (Mercato della demenza correlata al morbo di Parkinson), etc.

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https://exactitudeconsultancy.com/reports/72371/rnai-drug-delivery-market

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https://exactitudeconsultancy.com/reports/72370/epigenomics-market

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https://exactitudeconsultancy.com/reports/72369/astaxanthin-market

About Us
Exactitude Consultancy is a market research & consulting services firm which helps its client to address their most pressing strategic and business challenges. Our market research helps clients to address critical business challenges and also helps make optimized business decisions with our fact-based research insights, market intelligence, and accurate data.
https://bulletin.exactitudeconsultancy.com/

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https://exactitudeconsultancy.com/

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