Rise In Infectious Diseases Fueling The Growth Of The Market Due To Increasing Global Travel And Pathogen Transmission Emerges as a Core Driver of the Oral Vaccine Market in 2025

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What Is the Expected CAGR for the Oral Vaccine Market Through 2025?
In recent years, the market size for oral vaccines has experienced rapid expansion. It's projected to increase from $3.59 billion in 2024 to $3.95 billion in 2025, demonstrating a compound annual growth rate (CAGR) of 10.1%. The historical growth can be credited to a rise in funding for vaccine research and development, positive regulatory assistance for oral vaccine testing, boosted global tourism, the necessity for large-scale immunization during pandemic occurrences, and the development of cold chain infrastructure.

What's the Projected Size of the Global Oral Vaccine Market by 2029?
In the upcoming years, the oral vaccine market size is anticipated to witness robust growth. It is projected to reach $5.74 billion by 2029, with a compound annual growth rate (CAGR) of 9.8%. This projected growth for the period is linked to the increasing global presence of infectious diseases, growing demand for vaccination without the use of needles, greater approval rates amongst pediatric patients, enhanced patient adherence, and expansion of government-led immunization schemes. Key trends expected during this forecast period are the rise of new oral vaccine technologies, advances in oral drug delivery, collaborations between the private and public sectors, the creation of oral vaccines for non-conventional diseases, and new developments in formulation and encapsulation techniques.

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Top Growth Drivers in the Oral Vaccine Industry: What's Accelerating the Market?
The escalating incidence of infectious diseases is anticipated to spur the expansion of the oral vaccine market. Infectious diseases, caused by harmful microorganisms such as bacteria, viruses, fungi, or parasites, are transmittable among individuals or via the environment. The global spread of these diseases is exacerbated by increased international travel, which facilitates the quick cross-border transportation of both people and microbes, thereby hastening the global dissemination of infections. Oral vaccines are advantageous in combating infectious diseases as they activate mucosal immunity in the gut - a common entry route for many infectious agents. This enables effective defense at the infection site. For instance, the Health Security Agency, a government department located in the UK, reported in May 2025 that England saw an 11.0% increase in tuberculosis (TB) cases in 2023 compared to 2022. Hence, the expanding incidence of infectious diseases is fuelling the growth of the oral vaccine market.

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Which Fast-Growing Trends Are Poised to Disrupt the Oral Vaccine Market?
Leading businesses in the oral vaccine market are prioritizing the creation of inventive products like second-generation oral pill vaccines to bolster immune response and simplify administration. Second-generation pill vaccines are engineered to enhance immunogenicity, expand protection, and make mass immunization more efficient without the use of cold-chain storage or needles. For example, in March 2025, Vaxart Inc., a biotechnology firm based in the U.S., initiated a Phase 1 clinical trial for its second-generation oral norovirus vaccine that is administered in pill form. This trial is set to assess the improved immune responses and safety characteristics of the updated constructs, with the goal of meeting the ongoing worldwide demand for accessible and effective norovirus vaccines. The pill format eliminates impediments associated with injectable vaccines and facilitates swift, large-scale distribution, especially during outbreaks.

What Are the Main Segments in the Oral Vaccine Market?
The oral vaccine market covered in this report is segmented

1) By Vaccine Type: Live Attenuated Vaccines, Inactivated Vaccines, Subunit Vaccines, Other Vaccine Types
2) By Application: Polio, Tuberculosis, Rabies, Influenza, Cholera, Other Applications
3) By End-User: Hospital , Clinics, Government Organization, Other End-Users

Subsegments:
1) By Live Attenuated Vaccines: Oral Polio Vaccine (OPV), Rotavirus Vaccine, Oral Typhoid Vaccine, Oral Cholera Vaccine
2) By Inactivated Vaccines: Inactivated Polio Vaccine (IPV), Inactivated Cholera Vaccine, Inactivated Hepatitis A Vaccine
3) By Subunit Vaccines: Protein Subunit Vaccines, Polysaccharide Vaccines, Conjugate Vaccines
4) By Other Vaccine Types: DNA Vaccines, RNA Vaccines, Virus-Like Particle (VLP) Vaccines, Recombinant Vector Vaccines

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Which Top Companies are Driving Growth in the Oral Vaccine Market?
Major companies operating in the oral vaccine market are Pfizer Inc., Johnson & Johnson, Merck & Co., Sanofi SA, AstraZeneca Plc, Novartis AG, GlaxoSmithKline Plc, Sinovac Biotech Ltd., Panacea Biotec Ltd., Emergent BioSolutions Inc., Zydus Lifesciences, Serum Institute of India Pvt. Ltd., Bharat Biotech Ltd., Adimmune, Haffkine Biopharmaceutical Co. Ltd., Changchun BCHT Biotechnology Co., BIBCOL, Medigen Vaccine Biologics Corp., BlueWillow Biologics Inc., BioNet Asia Co. Ltd., and Innovax.

Which Regions Will Dominate the Oral Vaccine Market Through 2029?
North America was the largest region in the oral vaccine market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the oral vaccine market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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