Pigment Epithelial Detachment Market Outlook: Aging Population, AI-Driven Diagnosis, and Novel Therapies to Drive Growth | DelveInsight

Retinal pigment epithelium market is poised for notable growth, being fueled by several factors, including an aging population, advancements in AI-driven diagnosis, industry collaborations, and novel therapeutic options. Key retinal pigment epithelium companies include Sumitomo Pharma, Healios, Eyestem Research, Luxa Biotechnology, Regenerative Patch Technologies, Lineage Cell Therapeutics, Katairo GmbH, Visgenx Inc., Astellas Pharma Inc., Roche, ONL Therapeutics, and Novartis, among others.
DelveInsight's report, "Pigment Epithelial Detachment - Market Insight, Epidemiology and Market Forecast [https://www.delveinsight.com/report-store/pigment-epithelial-detachment-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=xpr]", provides a comprehensive assessment of retinal pigment epithelium market dynamics, disease epidemiology, and treatment advancements across the 7MM. The report forecasts that the retinal pigment epithelium market size in these regions, which include the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan, is expected to increase significantly in the coming years. This growth will be largely due to an aging population, industry collaborations, and advancements in technologies such as AI-driven diagnostics, telehealth, and therapeutic innovations.

The US currently holds the largest retinal pigment epithelium market share, a trend anticipated to continue due to ongoing innovations in anti-VEGF therapies and advancements in the treatment pipeline. Moreover, Japan's growth rate could surpass others, owing to its aging population and a higher prevalence of PCV-related PED.

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The epidemiological data presented in the report indicate key trends in incidence, demographics, and the retinal pigment epithelium patient pool. Pigment epithelial detachment is a significant retinal disorder, often associated with age-related macular degeneration (AMD), central serous chorioretinopathy (CSCR), and other retinal diseases, leading to a marked increase in prevalence among the elderly. The average age of patients with drusenoid retinal pigment epithelium is 77 years.

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The report also examines the current and evolving retinal pigment epithelium treatment landscape. Intravitreal anti-VEGF agents, like AVASTIN (Roche), Ranibizumab, and Aflibercept, remain the cornerstone for treating vascularized PEDs associated with neovascular AMD. Combination therapies, particularly those that involve anti-VEGF agents alongside photodynamic therapy, such as, have shown promise for managing large or treatment-resistant pigment epithelial detachments.

ONL-1204, developed by ONL Therapeutics, is a novel, first-in-class small-molecule peptide currently in Phase II clinical trials for the treatment of pigment epithelial detachment. ONL-1204 works by inhibiting the Fas receptor to protect retinal cells and photoreceptors from apoptosis and preserve vision. In Phase I and II studies, ONL-1204 has demonstrated encouraging results, showing visual benefits, especially in patients at high risk of vision loss. The ongoing Phase II trial is evaluating two dosing regimens and will provide critical data to support further development towards pivotal Phase III studies.

Looking ahead, the pigment epithelial detachment treatment landscape is rapidly advancing, with significant progress in cell and gene therapy for retinal diseases, especially AMD. Research continues to refine techniques for retinal pigment epithelium transplantation, focusing on the development of new scaffolds and delivery methods to ensure proper oxygenation and cell adhesion for both RPE and outer retina cells.

Moreover, advancements in retinal imaging, such as Laser Doppler holography, are enhancing the visualization of blood flow and other retinal structures, which could improve diagnostics and treatment planning. In late 2024, machine learning algorithms for the automated detection of PEDs from optical coherence tomography images have shown promising results, with logistic regression models achieving over 96% accuracy.

In November 2024, LumiThera received FDA authorization to market its Valeda Light Delivery System, which is the first therapy utilizing photobiomodulation (PBM) to improve visual acuity in patients with intermediate AMD. This approval is based on data from the LIGHTSITE III trial (NCT04065490), which showed durable best-corrected visual acuity improvements of more than five letters maintained over 24 months. Additionally, research published in December 2024 highlighted the role of fatty acid desaturase 1 (FADS1) in RPE ferroptosis and AMD progression, identifying FADS1 inhibition as a potential therapeutic target, reflecting the active pace of development and market growth potential in PED treatments.

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In conclusion, despite facing challenges such as immune rejection in allogeneic transplants, surgical complications, high production costs, and limited accessibility, the retinal pigment epithelium market is on a strong growth trajectory, fueled by an aging population, innovative therapeutic strategies, and rapid technological advancements in diagnostics and imaging.

With promising developments in anti-VEGF agents, photobiomodulation therapies, and emerging gene and cell therapies, the treatment approach for PED is shifting towards more targeted, effective, and personalized care. As leading players continue to invest in research, collaboration, and innovative pipelines, the PED market is well-positioned for substantial transformation.

Table of Contents

1.

Key Insights

2.

Executive Summary of Pigment Epithelial Detachment

3.

Pigment Epithelial Detachment Competitive Intelligence Analysis

4.

Pigment Epithelial Detachment: Market Overview at a Glance

5.

Pigment Epithelial Detachment: Disease Background and Overview

6.

Pigment Epithelial Detachment Patient Journey

7.

Pigment Epithelial Detachment Epidemiology and Patient Population

8.

Treatment Algorithm, Current Treatment, and Medical Practices

9.

Pigment Epithelial Detachment Unmet Needs

10.

Key Endpoints of Pigment Epithelial Detachment Treatment

11.

Pigment Epithelial Detachment Marketed Products

12.

Pigment Epithelial Detachment Emerging Therapies

13.

Pigment Epithelial Detachment: Seven Major Market Analysis

14.

Attribute analysis

15.

7MM: Market Outlook

16.

Access and Reimbursement Overview of Pigment Epithelial Detachment

17.

KOL Views

18.

Pigment Epithelial Detachment Market Drivers

19.

Pigment Epithelial Detachment Market Barriers

20.

Appendix

21.

DelveInsight Capabilities

22.

Disclaimer

23.

About DelveInsight

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About DelveInsight

DelveInsight is a leading market research and consulting firm specializing in disease-specific insights and therapeutic market analysis. Their reports integrate real-world data, clinical trial findings, and expert interviews to deliver comprehensive industry intelligence.

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