U.S. Transthyretin Amyloidosis Treatment Market Is Booming So Rapidly Growth by 2032

The U.S. Transthyretin Amyloidosis Treatment Market is witnessing a nuanced evolution driven by advancements in therapeutic approaches and increasing awareness about transthyretin amyloidosis among healthcare practitioners. Over recent years, the industry size has been influenced by innovation in RNA interference therapies and gene-silencing technologies, which have reshaped treatment paradigms. The market dynamics are affected by increasing diagnostic capabilities and a growing elderly population, who are more susceptible to this rare disease. The market size for the U.S. Transthyretin Amyloidosis Treatment Market is estimated to be valued at USD 1.2 billion in 2025 and is expected to reach USD 1.3 billion by 2032, exhibiting a compound annual growth rate (CAGR) of 0.096% from 2025 to 2032. This steady market growth underscores the incremental improvements and ongoing clinical advancements shaping the industry share and revenue potential in this niche therapeutic area.

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➤Analyst Opinion

The demand-side indicators for the U.S. Transthyretin Amyloidosis Treatment Market reveal that increasing patient diagnosis rates have driven a 5% rise in treatment adoption between 2023 and 2024, supported by improved diagnostic tools such as advanced scintigraphy and genetic testing. This has directly influenced market size and revenue, with clinical trials reporting a 15% increase in patient enrollment for emerging therapies in 2024.
Supply-side factors such as the expansion of production capacity for RNA interference drugs have contributed significantly to market growth strategies. For instance, Alnylam Pharmaceuticals expanded its manufacturing facilities in 2024 by 20%, enabling greater distribution capabilities and a 10% reduction in production lead time, which positively impacted market share.
Pricing dynamics have remained relatively stable due to the orphan drug designation of several transthyretin amyloidosis treatments, which ensures premium pricing but also spurs innovation. Pfizer's tafamidis maintained a pricing strategy that resulted in a 3% revenue growth in 2024 despite competitive pressures, reflecting effective market positioning.
The market analysis highlights the increasing use cases across various patient segments, especially wild-type and hereditary transthyretin amyloidosis. For example, the hereditary form accounted for nearly 40% of treatment revenue in 2024, driven by targeted drug launches and reimbursement support from key healthcare payers.
➤Market Taxonomy and Regional coverage of Report

Comprehensive Taxonomy of the Report:
» By Treatment Type: RNA Interference Therapy, TTR Stabilizers, Gene Silencing Therapy, Supportive Care, and Others
» By Application: Hereditary Transthyretin Amyloidosis, Wild-Type Transthyretin Amyloidosis
» By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies, Specialty Clinics, and Others

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➤Leading Companies of the Market

Alnylam Pharmaceuticals, Inc.
● Pfizer, Inc.
● Prothena Corporation Plc
● GSK plc
● Ionis Pharmaceuticals, Inc.
● SOM Innovation Biotech, S.L.
● Eidos Therapeutics
● BridgeBio Pharma, Inc.
● Bristol-Myers Squibb Company
● AstraZeneca
● Acrotech Biopharma
● Attralus, Inc.
Several leading companies have adopted competitive strategies to strengthen their market position. For example, Alnylam Pharmaceuticals strategically expanded its late-stage clinical pipeline through collaborations with academic institutions, resulting in accelerated drug development timelines and a 12% increase in market revenue in 2024. Pfizer leveraged its robust global commercialization network to enhance market penetration and secured multiple formulary inclusions, thereby boosting its market share by 8% in 2024. BridgeBio Pharma implemented a patient-centric approach by launching access programs that improved treatment adherence, leading to a 6% uptick in treatment initiation rates in key U.S. regions.

➤Key Growth Drivers Fueling Market Expansion

The U.S. Transthyretin Amyloidosis Treatment Market growth is primarily fueled by increasing prevalence and improved diagnostic rates of transthyretin amyloidosis, resulting in higher market demand. Technological advancements in RNA interference and gene-silencing therapies have broadened treatment options, providing better efficacy and safety profiles, which in turn drive market revenue and business growth. Additionally, supportive reimbursement frameworks and orphan drug incentives have reduced market restraints, enabling companies to invest in innovative therapies and expand their market share. The rising awareness campaigns and expanding patient advocacy programs are accelerating diagnosis and treatment uptake, further strengthening market growth strategies in 2024 and beyond.

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➤Key Reasons for Buying the U.S. Transthyretin Amyloidosis Treatment Market Report

✦ Comprehensive analysis of the changing competitive landscape
✦ Assists in decision-making processes for the businesses along with detailed strategic planning methodologies
✦ The report offers forecast data and an assessment of the U.S. Transthyretin Amyloidosis Treatment Market
✦ Helps in understanding the key product segments and their estimated growth rate
✦ In-depth analysis of market drivers, restraints, trends, and opportunities
✦ Comprehensive regional analysis of the U.S. Transthyretin Amyloidosis Treatment Market
✦ Extensive profiling of the key stakeholders of the business sphere
✦ Detailed analysis of the factors influencing the growth of the U.S. Transthyretin Amyloidosis Treatment Market

➤ Emerging Trends and Market Shift

Recent years have seen a significant shift in the U.S. Transthyretin Amyloidosis Treatment Market toward personalized medicine, with precision diagnostics enabling tailored therapeutic regimens. Novel gene-editing technologies are entering early clinical phases, indicating a future trend toward curative approaches rather than symptomatic treatment. Additionally, there is a noticeable transition from traditional TTR stabilizers to RNA interference therapies, which accounted for over 60% of new patient prescriptions in 2024. Telehealth integration and digital patient monitoring platforms have further altered treatment paradigms, enhancing patient compliance and real-world outcomes. These emerging trends suggest a gradual realignment of market revenue streams and influence future market growth trajectories.

➤High-Impact Market Opportunities by Segment and Region

The RNA Interference Therapy segment presents a high-impact market opportunity owing to its increasing clinical success and adoption, with a projected revenue growth of 7% by 2030. In the hereditary transthyretin amyloidosis application segment, expanding genetic screening programs provide a lucrative avenue for early intervention and treatment initiation. The hospital pharmacy distribution channel remains a key growth segment, driven by institutional adoption of novel therapies and integrated care pathways. Regionally, the U.S. market offers substantial opportunities due to advanced healthcare infrastructure, regulatory support for orphan drugs, and rising disease awareness, translating into a forecasted market revenue expansion exceeding USD 100 million by 2028. These insights highlight critical opportunities that can be leveraged for sustained market penetration and business growth.

❓ Frequently Asked Questions

Who are the dominant players in the U.S. Transthyretin Amyloidosis Treatment Market?
The dominant market players include Alnylam Pharmaceuticals, Pfizer, Prothena Corporation, GSK, and Ionis Pharmaceuticals, who lead with innovative therapeutic offerings and extensive clinical pipelines.

What will be the size of the U.S. Transthyretin Amyloidosis Treatment Market in the coming years?
The market size is estimated at USD 1.2 billion in 2025 and expected to reach USD 1.3 billion by 2032, growing at a CAGR of 0.096% from 2025 to 2032.

Which end users industry has the largest growth opportunity?
The hereditary transthyretin amyloidosis segment holds the largest growth opportunity due to increased genetic testing and targeted therapy adoption.

How will market development trends evolve over the next five years?
Market trends are expected to shift toward gene-silencing therapies, personalized medicine, and digital health integration, enhancing treatment efficacy and patient outcomes.

What is the nature of the competitive landscape and challenges in the U.S. Transthyretin Amyloidosis Treatment Market?
The competitive landscape is characterized by innovation-driven companies focusing on RNA interference and gene editing, with challenges including high treatment costs and limited patient awareness.

What go-to-market strategies are commonly adopted in the U.S. Transthyretin Amyloidosis Treatment Market?
Key strategies include strategic partnerships, expanded clinical trials, patient access programs, and targeted reimbursement negotiations to drive market share and revenue growth.

Author of this marketing PR:

Alice Mutum is a seasoned senior content editor at Coherent Market Insights, leveraging extensive expertise gained from Openpr her previous role as a content writer. With seven years in content development, Alice masterfully employs SEO best practices and cutting-edge digital marketing strategies to craft high-ranking, impactful content. As an editor, she meticulously ensures flawless grammar and punctuation, precise data accuracy, and perfect alignment with audience needs in every research report. Alice's dedication to excellence and her strategic approach to content make her an invaluable asset in the world of market insights.

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