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Oligonucleotide API Market Share & Forecast 2025 to 2035 Key Players Merck KGaA, LGC Biosearch Technologies, RiboBio Co., Nitto Denko and Others

08-01-2025 08:08 AM CET | Health & Medicine

Press release from: Future Market Insights Inc

Oligonucleotide API Market

Oligonucleotide API Market

The global oligonucleotide API market is on a strong growth trajectory, with a new market outlook projecting a robust compound annual growth rate (CAGR) of 5.60% from 2024 to 2034. The market is expected to grow from a valuation of USD 2.81 billion in 2024 to USD 4.84 billion by the end of the forecast period. This expansion is primarily driven by the increasing global need for new drug classes and innovative therapeutic solutions.

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Key Drivers: New Drug Pipelines & Precision Medicine

The market's growth is fueled by an expanding pipeline of oligonucleotide-based active pharmaceutical ingredients (APIs) and the rise of precision medicine. Key drivers include the adoption of CRISPR-Cas gene editing, the increasing use of RNA-based therapeutics such as mRNA vaccines, and the growing application of oligonucleotides in molecular diagnostics. These advancements enable highly specific, targeted therapeutic interventions, moving the industry toward personalized treatment approaches.

Trends and Industry Challenges

The market is currently navigating significant complexities. While there is a surge in strategic collaborations and investments, the industry still faces hurdles such as high R&D costs for therapies targeting smaller patient populations and time-consuming manufacturing processes. However, innovations in delivery systems, like lipid nanoparticles, are enhancing drug efficacy and safety. This has increased the demand for specialized synthesis services from Contract Development & Manufacturing Organizations (CDMOs).

Dominant Market Segments

Antisense Oligonucleotides (ASOs) APIs are a major market driver, currently holding a dominant 78% share. Their popularity stems from their therapeutic potential in treating a wide range of conditions, including rare genetic disorders and cancer. In terms of end-users, pharmaceutical and biopharmaceutical companies lead the market, accounting for a 49% share, supported by significant investor interest and funding in oligonucleotide-based therapies.

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Strong Regional Growth

Geographically, the market is seeing robust expansion in key regions. India is a leading growth engine, with a projected CAGR of 7.80%, thanks to its thriving pharmaceutical manufacturing infrastructure and cost-competitive solutions. Thailand and Malaysia also show significant promise, driven by supportive government policies and strategic investments in biotechnology.

Competitive Landscape & Recent Developments

The competitive landscape is dominated by a few key players, including Jazz Pharmaceuticals, Inc., Sarepta Therapeutics, and Biogen. The focus is on innovation and strategic partnerships to scale production and meet rising demand. Recent developments include ST Pharm's major investment to expand its manufacturing capacity and a strategic collaboration between Bachem and Eli Lilly & Co. These moves highlight the industry's commitment to accelerating the development of this transformative class of drugs.

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About Future Market Insights (FMI)

Future Market Insights, Inc. (ESOMAR certified, recipient of the Stevie Award, and a member of the Greater New York Chamber of Commerce) offers profound insights into the driving factors that are boosting demand in the market. FMI stands as the leading global provider of market intelligence, advisory services, consulting, and events for the Packaging, Food and Beverage, Consumer Technology, Healthcare, Industrial, and Chemicals markets. With a vast team of over 400 analystsworldwide, FMI provides global, regional, and local expertise on diverse domains and industry trends across more than 110 countries.

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