Hypertriglyceridemia Clinical, Companies, Therapeutic Assessment, Therapies, Treatment Algorithm, Pipeline Analysis | NorthSea Therapeutics, Arrowhead Pharmaceuticals, Zhejiang Doer Biologics, Ionis Pharmaceuticals, GeneCradle, MediciNova, Regeneron Pharm

Hypertriglyceridemia Pipeline constitutes 18+ key companies continuously working towards developing 20+ Hypertriglyceridemia treatment therapies, analyzes DelveInsight.

Hypertriglyceridemia Overview:

Hypertriglyceridemia is a condition marked by high triglyceride levels in the blood, often linked to a greater risk of cardiovascular disease (CVD) and acute pancreatitis. It commonly arises from factors like uncontrolled diabetes, obesity, physical inactivity, and inherited disorders. While most cases remain symptom-free until triglyceride levels surpass 1000-2000 mg/dL, severe elevations can result in complications such as pancreatitis and metabolic imbalances. Treatment mainly focuses on lifestyle changes-healthy diet, weight loss, and regular exercise-along with medications like statins or fibrates when needed. Managing contributing conditions is essential to reduce health risks.

Although often silent, hypertriglyceridemia can present symptoms when triglyceride levels are very high. Once levels exceed 500 mg/dL, the likelihood of acute pancreatitis increases, with symptoms such as intense abdominal pain, nausea, and vomiting. In hereditary forms, individuals may develop xanthomas-yellowish fatty deposits on the skin near the eyes, elbows, or knees. Less frequent signs include hepatosplenomegaly (enlarged liver and spleen) and lipemia retinalis, a visual disturbance. While the condition may not produce immediate symptoms, it signals broader metabolic issues and significantly heightens the risk of heart disease.

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"Hypertriglyceridemia Pipeline Insight 2025" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Hypertriglyceridemia Therapeutics Market.

Key Takeaways from the Hypertriglyceridemia Pipeline Report

DelveInsight's Hypertriglyceridemia pipeline report depicts a robust space with 18+ active players working to develop 20+ pipeline therapies for Hypertriglyceridemia treatment.
The FDA granted approval in December 2024 for Tryngolza® (olezarsen), an injectable antisense oligonucleotide targeting apoC‐III, specifically indicated as an adjunct to diet for adults with familial chylomicronemia syndrome (FCS). It's the first-ever FDA-approved treatment for FCS.
Key Hypertriglyceridemia companies such as NorthSea Therapeutics, Arrowhead Pharmaceuticals, Zhejiang Doer Biologics, Ionis Pharmaceuticals, GeneCradle, MediciNova, Regeneron Pharmaceuticals, and others are evaluating new drugs for Hypertriglyceridemia to improve the treatment landscape.
Promising Hypertriglyceridemia pipeline therapies in various stages of development include SEFA-1024, DR10624, GC304, and others.

Hypertriglyceridemia Pipeline Analysis
The report provides insights into:
The report provides detailed insights into the key companies that are developing therapies in the Hypertriglyceridemia Market.
The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Hypertriglyceridemia treatment.
It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Hypertriglyceridemia market.

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Hypertriglyceridemia Emerging Drugs

SEFA-1024 - NorthSea Therapeutics

SEFA-1024 is an orally administered, semi-synthetic derivative of eicosapentaenoic acid designed to specifically target the gut and liver. It is being developed for the treatment of severe hypertriglyceridemia (sHTG), a condition that not only heightens the risk of acute pancreatitis but may also elevate cardiovascular risk. Current treatment options often fall short in effectively managing triglycerides (TG), non-HDL cholesterol, and glycemic control, leaving a significant unmet need. Supported by robust preclinical data from a relevant human HTG model, SEFA-1024 shows promise in addressing these gaps. The drug is presently in Phase II clinical trials for hypertriglyceridemia.
DR10624 - Doer Biologics

DR10624 is a first-in-class, long-acting tri-agonist that simultaneously targets FGF21R, GLP-1R, and the glucagon receptor (GCGR). Developed using Doer Biologics' proprietary MultipleBody platform, it is designed to offer balanced efficacy across multiple metabolic pathways. Preclinical studies have shown that DR10624 can significantly reduce body weight, lower triglyceride levels, improve lipid profiles, and enhance liver health. The drug is currently undergoing Phase II clinical trials for the treatment of severe hypertriglyceridemia.

Hypertriglyceridemia Companies

Around 18 or more key companies are actively working on developing therapies for Hypertriglyceridemia. Among them, NorthSea Therapeutics stands out with its drug candidate currently in the most advanced stage of development-Phase II clinical trials.

DelveInsight's report covers around 75+ products under different phases of clinical development like

Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates

Hypertriglyceridemia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

Intravenous
Subcutaneous
Oral
Intramuscular

Hypertriglyceridemia Products have been categorized under various Molecule types such as

Monoclonal antibody
Small molecule
Peptide

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Hypertriglyceridemia Pipeline Therapeutic Assessment
• Hypertriglyceridemia Assessment by Product Type
• Hypertriglyceridemia By Stage
• Hypertriglyceridemia Assessment by Route of Administration
• Hypertriglyceridemia Assessment by Molecule Type

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Table of Content

1. Report Introduction
2. Executive Summary
3. Hypertriglyceridemia Current Treatment Patterns
4. Hypertriglyceridemia - DelveInsight's Analytical Perspective
5. Therapeutic Assessment
6. Hypertriglyceridemia Late-Stage Products (Phase-III)
7. Hypertriglyceridemia Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Hypertriglyceridemia Discontinued Products
13. Hypertriglyceridemia Product Profiles
14. Hypertriglyceridemia Key Companies
15. Hypertriglyceridemia Key Products
16. Dormant and Discontinued Products
17. Hypertriglyceridemia Unmet Needs
18. Hypertriglyceridemia Future Perspectives
19. Hypertriglyceridemia Analyst Review
20. Appendix
21. Report Methodology

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Contact Info:
Kritika Rehani
krehani@delveinsight.com
info@delveinsight.com
+14699457679

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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