openPR Logo
Press release

Metastatic HR+/HER2 Breast Cancer Market: Epidemiology, Pipeline Products, Companies Working, DelveInsight | Pfizer, Novartis, AstraZeneca Pharmaceuticals, Eli Lilly, Jiangsu HengRui Medicine, Odonat

07-30-2025 08:56 PM CET | Business, Economy, Finances, Banking & Insurance

Press release from: ABNewswire

Metastatic HR+/HER2? Breast Cancer Market

Metastatic HR+/HER2? Breast Cancer Market

The total HR+/HER2- breast cancer market size in the 7MM was nearly USD 10 billion in 2023, which is expected to grow by 2034 with the launch of potential emerging therapies, assisted by an increase in the HR+/HER2- breast cancer patient pool.

Emerging therapies for Metastatic HR+/HER2 Breast Cancer, including KISQALI (ribociclib), PIQRAY (alpelisib), ARV-471 (vepdegestrant), OP1250 (palazestrant), and others, are anticipated to drive significant growth in the Metastatic HR+/HER2 Breast Cancer market in the coming years.

DelveInsight has launched a new report on "Metastatic HR+/HER2 Breast Cancer - Market Insights, Epidemiology, and Market Forecast-2034" that delivers an in-depth understanding of the Metastatic HR+/HER2 Breast Cancer, historical and forecasted epidemiology as well as the Metastatic HR+/HER2 Breast Cancer market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

Download sample report @ https://www.delveinsight.com/report-store/hr-positive-her2-negative-breast-cancer-market-insights?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr

Some of the key facts of the Metastatic HR+/HER2 Breast Cancer Market Report:

*
The HR+/HER2- subtype remains the most common of all breast cancer types. In 2023, the market size for HR+/HER2- breast cancer across the 7MM reached nearly USD 10 billion and is projected to grow by 2034, driven by emerging therapies and a rising patient population.

*
For the past decade, endocrine therapy has been the standard of care for HR+/HER2- breast cancer in both early and advanced stages. While FASLODEX (fulvestrant) is a widely used and effective single-agent endocrine therapy, its poor bioavailability and inconvenient IV administration highlight the need for next-generation oral selective estrogen receptor degraders (SERDs) in first- and second-line settings.

*
CDK4/6 inhibitors such as palbociclib, ribociclib, and abemaciclib have transformed treatment by improving progression-free survival in first- and second-line therapy. IBRANCE (palbociclib) leads the first-line setting, benefiting from a first-mover advantage and the highest sales. According to NCCN guidelines, KISQALI (ribociclib) is the preferred CDK4/6 inhibitor for first-line treatment when combined with an aromatase inhibitor (AI) in HR+/HER2- metastatic breast cancer (MBC). ORSERDU is another milestone therapy, becoming the first drug approved specifically for ER+, HER2- tumors with ESR1 mutations.

*
The treatment landscape is expanding beyond CDK4/6 inhibitors. Late-stage therapies such as Antibody-Drug Conjugates (ADCs) and oral SERDs are anticipated to have a significant impact post-CDK4/6 inhibitor therapy. Other investigational classes include AKT inhibitors, mTOR inhibitors, SERMs, PI3K inhibitors, PARP inhibitors, and TROP2-targeting ADCs. Roche's Giredestrant (with palbociclib) may compete with Camizestrant as a first-line option, though its Phase II trial failed to meet the primary endpoint. Capivasertib, an AKT inhibitor, and Dato-DXd, a TROP2 ADC with a BLA under FDA review (PDUFA Q1 2025), are among the most promising candidates.

*
The patient burden is substantial, with around 476,000 HR+/HER2- breast cancer cases in the 7MM in 2023, a number expected to rise through 2034. The United States reported the highest prevalence with about 208,400 cases, primarily in patients aged 60-79 (48% of cases). In the EU4 and the UK, Germany recorded the most cases (50,200), while Spain reported the fewest. Japan had approximately 43,000 treatment-eligible cases in 2023.

*
The emerging pipeline for HR+/HER2- therapies is highly competitive, with late-stage SERDs and other agents poised to meet unmet needs and drive market expansion. However, competition with established CDK4/6 inhibitors, which currently dominate the market, may temper their growth trajectory.

*
Key companies such as Pfizer, Novartis, AstraZeneca, Eli Lilly, Jiangsu HengRui Medicine, Odonate Therapeutics, Radius Pharmaceuticals, and Immunomedics are actively developing novel therapies to enhance treatment outcomes. Promising pipeline therapies include KISQALI (ribociclib), PIQRAY (alpelisib), ARV-471 (vepdegestrant), OP1250 (palazestrant), and others.

Key benefits of the Metastatic HR+/HER2 Breast Cancer market report:

*
Metastatic HR+/HER2 Breast Cancer market report covers a descriptive overview and comprehensive insight of the Metastatic HR+/HER2 Breast Cancer Epidemiology and Metastatic HR+/HER2 Breast Cancer market in the 7MM (the United States, EU5 (Germany, Spain, France, Italy, UK) & Japan.)

*
The Metastatic HR+/HER2 Breast Cancer market report provides insights on the current and emerging therapies.

*
Metastatic HR+/HER2 Breast Cancer market report provides a global historical and forecasted market covering drug outreach in 7MM.

*
The Metastatic HR+/HER2 Breast Cancer market report offers an edge that will help in developing business strategies by understanding trends shaping and driving the Metastatic HR+/HER2 Breast Cancer market.

Got queries? Click here to know more about the Metastatic HR+/HER2 Breast Cancer Market Landscape [https://www.delveinsight.com/sample-request/hr-positive-her2-negative-breast-cancer-market-insights?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr]

Metastatic HR+/HER2 Breast Cancer Overview

HR+/HER2- breast cancer is the most common subtype, characterized by the presence of estrogen and progesterone hormone receptors but the absence of HER2 overexpression. This form of breast cancer generally has a more favorable prognosis and is often treated with hormone therapies that block hormone-related tumor growth. In advanced stages, treatment may involve a combination of surgery, radiation, chemotherapy, and targeted drugs like CDK4/6 inhibitors. Early diagnosis plays a critical role in improving outcomes, and support from both healthcare providers and loved ones is essential throughout the treatment journey.

The patient journey typically starts when symptoms arise, leading to a clinical assessment and imaging. A biopsy confirms the diagnosis and provides detailed information about the tumor. Staging tests then determine how far the cancer has spread, enabling a multidisciplinary team to develop a tailored treatment strategy. This usually includes hormone therapy and may also involve surgery, radiation, chemotherapy, or targeted agents. Emotional support is crucial to help patients manage the psychological burden of the disease, and consistent follow-up care allows for ongoing monitoring and treatment adjustments, increasing the chances of long-term survival and improved quality of life.

Metastatic HR+/HER2 Breast Cancer Treatment Market

The management of HR+/HER2- breast cancer typically involves a multimodal treatment strategy. Hormone therapy is a cornerstone, aiming to block estrogen's role in fueling cancer growth. Surgical interventions like lumpectomy or mastectomy are performed to remove tumors, often followed by radiation to eliminate any remaining cancer cells. In advanced or metastatic cases, chemotherapy or targeted therapies such as CDK4/6 inhibitors may be included. Treatment decisions are guided by factors like cancer stage, hormone receptor status, and patient preferences. Ongoing monitoring is essential to track progress and adapt the treatment plan for optimal outcomes and long-term survival.

A range of anti-estrogen therapies is available for early-stage, advanced, and metastatic breast cancer, including selective estrogen receptor modulators (SERMs), aromatase inhibitors (AIs), and selective estrogen receptor degraders (SERDs). Current research is exploring the combination of these hormonal therapies with targeted agents that inhibit the PI3K/AKT/mTOR or CDK4/6 pathways-an approach particularly beneficial for patients who have experienced recurrence or disease progression despite initial hormone therapy.

To know more about the rising Metastatic HR+/HER2 Breast Cancer market [https://www.delveinsight.com/report-store/hr-positive-her2-negative-breast-cancer-market-insights?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr]

Metastatic HR+/HER2 Breast Cancer Market Outlook

Over the past decade, endocrine therapy has remained the primary treatment for HR-positive, HER2-negative metastatic breast cancer, thanks to its effectiveness and tolerability. Aromatase inhibitors (AIs) like anastrozole, letrozole, and exemestane are commonly used, with treatment sometimes enhanced by targeted agents such as CDK4/6 or mTOR inhibitors in more complex cases.

CDK4/6 inhibitors, when combined with endocrine therapy, have notably improved progression-free survival, as demonstrated in trials like MONALEESA and PALOMA. In Japan, palbociclib and abemaciclib are approved, while newer agents such as ENHERTU (approved in Aug 2022 for HER2-low cases) and TRODELVY (approved in Feb 2023 for previously treated HR+/HER2- cases) have broadened treatment options.

However, resistance to CDK4/6 inhibitors often leads to a shift toward chemotherapy due to limited success with fulvestrant alone. Emerging therapies like antibody-drug conjugates (ADCs) and oral selective estrogen receptor degraders (SERDs) offer new hope for patients in post-CDK4/6 settings.

The treatment pipeline includes promising candidates like Giredestrant, Camizestrant, LY3484356, and Datopotamab deruxtecan, especially targeting HER2-low subtypes. The future of HR+/HER2- breast cancer care lies in developing personalized treatments and understanding biomarkers and resistance mechanisms more deeply.

Metastatic HR+/HER2- Positive Breast Cancer Marketed Drugs

*
KISQALI (ribociclib): Novartis

*
PIQRAY (alpelisib): Novartis

Metastatic HR+/HER2- Positive Breast Cancer Emerging Drugs

*
ARV-471 (vepdegestrant): Arvinas

*
OP1250 (palazestrant): Olema Pharmaceuticals

To explore more on the emerging therapies that are boosting the metastatic hr+/her2- breast cancer market, visit: https://www.delveinsight.com/sample-request/hr-positive-her2-negative-breast-cancer-market-insights?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr

Scope of the Metastatic HR+/HER2 Breast Cancer Market Report

*
Study Period: 2020-2034

*
Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]

*
Key Metastatic HR+/HER2 Breast Cancer Companies: Pfizer, Novartis, AstraZeneca Pharmaceuticals, Eli Lilly, Jiangsu HengRui Medicine, Odonate Therapeutics, Radius Pharmaceuticals, Immunomedics, and others

*
Key Metastatic HR+/HER2 Breast Cancer Therapies: KISQALI (ribociclib), PIQRAY (alpelisib), ARV-471 (vepdegestrant), OP1250 (palazestrant), and others

*
Metastatic HR+/HER2 Breast Cancer Therapeutic Assessment: Metastatic HR+/HER2 Breast Cancer current marketed and Metastatic HR+/HER2 Breast Cancer emerging therapies

*
Metastatic HR+/HER2 Breast Cancer Market Dynamics: Metastatic HR+/HER2 Breast Cancer market drivers and Metastatic HR+/HER2 Breast Cancer market barriers

*
Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies

*
Metastatic HR+/HER2 Breast Cancer Unmet Needs, KOL's views, Analyst's views, Metastatic HR+/HER2 Breast Cancer Market Access and Reimbursement

Table of Contents

1. Report Introduction

2. Executive Summary

3. SWOT analysis

4. Metastatic HR+/HER2 Breast Cancer Patient Share (%) Overview at a Glance

5. Metastatic HR+/HER2 Breast Cancer Market Overview at a Glance

6. Metastatic HR+/HER2 Breast Cancer Disease Background and Overview

7. Metastatic HR+/HER2 Breast Cancer Epidemiology and Patient Population

8. Country-Specific Patient Population of Metastatic HR+/HER2 Breast Cancer

9. Metastatic HR+/HER2 Breast Cancer Current Treatment and Medical Practices

10. Unmet Needs

11. Metastatic HR+/HER2 Breast Cancer Emerging Therapies

12. Metastatic HR+/HER2 Breast Cancer Market Outlook

13. Country-Wise Metastatic HR+/HER2 Breast Cancer Market Analysis (2020-2034)

14. Market Access and Reimbursement of Therapies

15. Market drivers

16. Market barriers

17. Appendix

18. Metastatic HR+/HER2 Breast Cancer Report Methodology

19. DelveInsight Capabilities

20. Disclaimer

21. About DelveInsight

Click here to read more about Metastatic HR+/HER2 Breast Cancer Market Outlook 2034 [https://www.delveinsight.com/report-store/hr-positive-her2-negative-breast-cancer-market-insights?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr]

Related Reports:

Metastatic HR+/HER2 Breast Cancer Pipeline Insights, DelveInsight

"Metastatic HR+/HER2 Breast Cancer Pipeline Insight, 2024" report by DelveInsight outlines comprehensive insights of present clinical development scenarios and growth prospects across the Metastatic HR+/HER2 Breast Cancer market. A detailed picture of the Metastatic HR+/HER2 Breast Cancer pipeline landscape is provided, which includes the disease overview and Metastatic HR+/HER2 Breast Cancer treatment guidelines.

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

Media Contact
Company Name: DelveInsight Business Research LLP
Contact Person: Kritika Rehani
Email:Send Email [https://www.abnewswire.com/email_contact_us.php?pr=metastatic-hrher2-breast-cancer-market-epidemiology-pipeline-products-companies-working-delveinsight-pfizer-novartis-astrazeneca-pharmaceuticals-eli-lilly-jiangsu-hengrui-medicine-odonat]
Phone: +14699457679
Address:304 S. Jones Blvd #2432
City: Las Vegas
State: Nevada
Country: United States
Website: https://www.delveinsight.com/

Legal Disclaimer: Information contained on this page is provided by an independent third-party content provider. ABNewswire makes no warranties or responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you are affiliated with this article or have any complaints or copyright issues related to this article and would like it to be removed, please contact retract@swscontact.com



This release was published on openPR.

Permanent link to this press release:

Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release Metastatic HR+/HER2 Breast Cancer Market: Epidemiology, Pipeline Products, Companies Working, DelveInsight | Pfizer, Novartis, AstraZeneca Pharmaceuticals, Eli Lilly, Jiangsu HengRui Medicine, Odonat here

News-ID: 4127113 • Views:

More Releases from ABNewswire

Total Joy Homecare Responds to Surging Demand for Senior Health Care Services in Greater Houston
Total Joy Homecare Responds to Surging Demand for Senior Health Care Services in …
Total Joy Homecare expands services to meet growing Houston demand for in-home senior care, offering non-medical support that helps families maintain independence and dignity at home. Houston's rapidly aging demographic has prompted local care provider Total Joy Homecare to expand its comprehensive support services, addressing the critical need for quality senior health care services [https://maps.app.goo.gl/hUcW1N7qWy5EdHJs5] throughout the Greater Houston area. The company's response comes as families increasingly seek reliable alternatives to
Texas Company Introduces On-Site Carrier Repair Services to Reduce Fleet Downtime
Texas Company Introduces On-Site Carrier Repair Services to Reduce Fleet Downtim …
Texas Reefer Solutions introduces mobile carrier repair services in Dallas, revolutionizing how transportation fleets handle refrigeration breakdowns by providing on-site professional repairs, eliminating route deviations, and reducing cargo-threatening delays. The transportation industry faces a significant challenge when refrigerated trucks require repairs, often forcing drivers to deviate from critical routes and schedules. Texas Reefer Solutions has emerged as a game-changing solution, introducing mobile carrier repair services [https://maps.app.goo.gl/P6nfg5WF7sckR7aZ8] that bring professional technicians directly
Family Therapy in Birmingham: How the Right Therapist Can Transform Relationships
Family Therapy in Birmingham: How the Right Therapist Can Transform Relationship …
Family therapy in Birmingham helps families improve communication, resolve conflict, and build stronger bonds. With the support of a qualified therapist near you, therapy creates a safe space to share, heal, and reconnect. Whether you're searching for therapy near me or counselling for your family, Phinity Therapy offers guidance for lasting change. Families are the foundation of our lives. They provide love, support, and connection, but they can also be the
Multiple Sclerosis Pipeline 2025: MOA, ROA, FDA-Approved Drugs, and Clinical Trial Progress Assessment by DelveInsight | Biogen, Immune Response BioPharma, Celgene, Novartis, Sanofi, Actelion, Bayer
Multiple Sclerosis Pipeline 2025: MOA, ROA, FDA-Approved Drugs, and Clinical Tri …
(Las Vegas, Nevada, United States) As per DelveInsight's assessment, globally, Multiple Sclerosis pipeline constitutes 75+ key companies continuously working towards developing 80+ Multiple Sclerosis treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight. The Multiple Sclerosis Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed

All 5 Releases


More Releases for HER2

Evolving Market Trends In The HER2-Positive Breast Cancer Industry: Innovative T …
Our market reports now include the latest updates on global tariffs, trade impacts, and evolving supply chain dynamics. What Is the Expected HER2-Positive Breast Cancer Market Size During the Forecast Period? Over the past few years, there has been a noteworthy expansion in the HER2-positive breast cancer market. The market, which is projected to increase from $10.21 billion in 2024 to $10.96 billion in the following year, predicts a compound annual growth
HER2 Inhibitors: Advancing Breast Cancer Treatments
"The Business Research Company recently released a comprehensive report on the Global HER2 Inhibitors Market Size and Trends Analysis with Forecast 2024-2033. This latest market research report offers a wealth of valuable insights and data, including global market size, regional shares, and competitor market share. Additionally, it covers current trends, future opportunities, and essential data for success in the industry. Ready to Dive into Something Exciting? Get Your Free Exclusive Sample
HER2 Positive Breast Cancer Pipeline Drugs 2024
DelveInsight's, "HER2 Positive Breast Cancer Pipeline Insight 2024" report provides comprehensive insights about 60+ companies and 65+ pipeline drugs in HER2 Positive Breast Cancer pipeline landscape. It covers the HER2 Positive Breast Cancer pipeline drug profiles, including clinical and nonclinical stage products. It also covers the HER2 Positive Breast Cancer therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in
HER2 Inhibitors: Targeted Therapies Transforming Cancer Treatment
HER2 inhibitors market is expected to gain market growth in the forecast period of 2021 to 2028. Data Bridge Market Research analyses the market to account to grow at a CAGR of 9% in the above mentioned forecast period. Global HER2 Inhibitors Market Scope and Market Size The HER2 inhibitors market is segmented on the basis of treatment, application, end-users and distribution channel. The growth amongst these segments will help you analyze
ADC Drugs For HER2 Positive Breast Cancer
According to the latest data, breast cancer has overtaken lung cancer to become the most common cancer among women, and the death rate is the second highest among female tumors, seriously affecting the physical and mental health of women around the world. Patients with abnormal expression of human epidermal growth factor receptor (HER2) account for 15%-20% of all breast cancers, which is highly invasive and has poor prognosis. Although more drug
HER2 negative Breast Cancer Pipeline involves 85+ key companies continuously wor …
DelveInsight's HER2 negative Breast Cancer Pipeline Insight 2022 report offers exhaustive global coverage of available, marketed, and pipeline therapies in different phases of clinical development, major pharmaceutical companies working to advance the pipeline space, and future growth potential of the HER2 negative Breast Cancer pipeline domain. Some of the essential takeaways from the HER2 negative Breast Cancer Pipeline report: • DelveInsight's HER2 negative Breast Cancer Pipeline analysis depicts a robust space with