Press release
Antibody Mediated Rejection Market Projects Growth from Early‐Stage Enzyme & Monoclonal Platform Pipelines
Antibody-Mediated Rejection
The Antibody Mediated Rejection (AMR) market is led by biotech leaders like CSL Behring, Hansa Biopharma, and Novartis, developing complement inhibitors, enzyme-based therapies, and IgG-cleaving platforms. Talaris Therapeutics, Amgen, Bristol-Myers Squibb, Eli Lilly, and Sanofi are advancing monoclonal antibodies and immunomodulators in transplant care. Teva and Biogen complement the field through biosimilars and therapeutic antibodies.
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Antibody Mediated Rejection Market M&A & Collaborative Deals
1. Biogen's acquisition of Human Immunology Biosciences (HI Bio) for US$1.8 billion in May 2024, securing felzartamab, a BTD-designated anti-CD38 antibody for AMR, boosting its late-stage pipeline.
2. Hansa Biopharma's positive Phase II imlifidase AMR data, reported in early 2025, reinforces its enzyme-cleaving platform and may accelerate collaborative licensing.
3. Talaris or CSL deal rumored, aligning their complement inhibitor portfolios (no firm public M&A yet), spotlighting increasing deal momentum in AMR biologic innovation.
As per our analysis, these events highlight the sector's strategic direction, focusing on enzyme and biologic innovation, licensing for next-gen AMR assets, and clinical acceleration partnerships rather than traditional consolidation.
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Key Growth Drivers & Emerging Opportunities in the Antibody-Mediated Rejection Market
• Growth in organ transplants, especially among elderly patients, is increasing AMR incidence.
• Breakthroughs in enzyme-based agents like imlifidase are enabling rapid removal of donor-specific antibodies.
• Complement inhibition therapies are gaining momentum as targeted options for AMR prevention and treatment.
• Regulatory support (BTD, Orphan Drug) expedites the development of novel AMR therapies like felzartamab.
• Collaborations and licensing are expanding pipelines in biosimilars, monoclonals, and next-gen biologics.
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Regional Market Drivers for the Antibody-Mediated Rejection Market
North America dominates due to leading transplant volumes, mature immunology R&D, and biotech investment.
Europe sustains growth through robust transplant infrastructure, complement inhibitor adoption, and multi-country clinical studies.
Asia Pacific is rapidly expanding, propelled by increasing transplants, growing AMR awareness, and rising biotech investment.
Latin America, the Middle East & Africa are emerging markets with expanding transplant access and regulatory backing for AMR therapies.
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