Parkinson's Disease Pipeline Appears Robust With 130+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight

DelveInsight's, "Parkinson's Disease Pipeline Insight, 2025" report provides comprehensive insights about 130+ companies and 150+ pipeline drugs in Parkinson's Disease pipeline landscape. It covers the Parkinson's Disease pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Parkinson's Disease pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the Parkinson's Disease Pipeline Report

* In June 2025, Zomagen Biosciences Ltd . announced a study to understand if taking VTX3232 is safe in participants diagnosed with early stage idiopathic Parkinson's Disease (PD). Approximately 10 patients will take VTX3232 Dose A. The study consists of a 30-day Screening Period (to see if a participant qualifies for the study), a 7-day Pre-Baseline Period, a 28-day Open Label Treatment period (a participant receives active Dose A), and a 14-day Follow-Up Period.
* In June 2025, MDD US Operations, LLC a subsidiary of Supernus Pharmaceuticals conducted a Phase 3, multicenter, open-label, safety and tolerability study of continuous apomorphine infusion in subjects with advanced Parkinson's Disease (PD) whose motor fluctuations remain unsatisfactory with levodopa (or levodopa/carbidopa) and at least one other class of drugs or mode of therapy for PD.
* DelveInsight's Parkinson's Disease Pipeline report depicts a robust space with 130+ active players working to develop 150+ pipeline therapies for Parkinson's Disease treatment.
* The leading Parkinson's Disease Companies such as Annovis Bio, Cerevel Therapeutics, Roche, Inhibikase Therapeutics, Inc, Gain Therapeutics, Neuronascent, ANEW MEDICAL, Longevity Biotech, Minerva Neurosciences/Mitsubishi Tanabe Pharma Corporation, Tetraneuron, Kallyope, BlueRock Therapeutics LP, Neuraly, Peptron/Yuhan Corporation, Genentech, Kissei Pharmaceutical, Asklepios BioPharmaceutical, Alkahest, Modag, Intra-Cellular Therapies, Living Cell Technologies, MedImmune and others.
* Promising Parkinson's Disease Pipeline Therapies such as VTX3232, Rasagiline, Safinamide Methanesulfonate, Levetiracetam, CTC-413, CVXL-0107, Levodopa, Rotigotine, Istradefylline 20 mg or 40 mg, IPX054 100 mg and others.

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Parkinson's Disease Emerging Drugs Profile

* Buntanetap: Annovis Bio

Buntanetap (formerly known as Posiphen or ANVS401) targets neurodegeneration by inhibiting the formation of multiple neurotoxic proteins, including amyloid beta, tau, alpha-synuclein, and TDP43. By improving synaptic transmission, axonal transport, and reducing neuroinflammation, Buntanetap aims to reverse neurodegeneration in AD, PD, and other neurodegenerative diseases, thereby aiming to restore brain function and improve the quality of life for patients. Currently, the drug is in Phase III trial for the treatment of Parkinson's disease.

* Tavapadon: Cerevel Therapeutics

Tavapadon is the first and only selective D1/D5 receptor partial agonist in development for Parkinson's disease and is currently being studied as a once-daily medicine for use as both a monotherapy and as an adjunctive therapy to LD. Tavapadon is designed to selectively and optimally activate D1/D5 receptors to potentially provide the right balance of motor control, safety and tolerability for patients. By selectively activating D1/D5 dopamine receptors along the nigrostriatal pathway, tavapadon has the potential to offer the right balance of dopamine signaling to improve motor control while avoiding D2/D3 overstimulation, which is believed to underlie many of the side effects of current dopamine agonists. Additionally, as a partial agonist with a 24-hour half-life enabling once-daily dosing, tavapadon may avoid hyper activation of the dopamine receptors, which can lead to troublesome dyskinesias. Currently, the drug is in Phase III trial for the treatment of Parkinson's disease.

* Prasinezumab: Roche

Prasinezumab (RG7935) is a monoclonal antibody targeting alpha-synuclein, a protein that may misfold and be involved in the pathogenesis of Parkinson's disease. It has been tested in preclinical models of synuclein-related disease and has shown a reduction of neurodegeneration. Currently, the drug is in Phase II trial for the treatment of Parkinson's disease.

* Risvodetinib: Inhibikase Therapeutics, Inc

Risvodetinib (IkT-148009), is a potent, selective small-molecule designed and engineered as chronically administered, once-daily oral medication targeting the underlying biological mechanism resulting in Parkinson's disease, with the goal of halting disease progression and reversing functional loss. Risvodetinib (IkT-148009) is designed to block the activation of Abl kinase, a clinically validated drug target, to halt and reverse the loss of dopamine-secreting neurons in the brain and GI tract by restoring neuroprotective mechanisms. Currently, the drug is in Phase II trial for the treatment of Parkinson's disease.

* GT 02287: Gain Therapeutics

GT-02287, is an allosteric regulator of GCase and is in development for the treatment of PD, with GBA1-PD as the lead indication. The orally administered, brain-penetrant small molecule restores the function of GCase. In preclinical models of PD, GT-02287 restored GCase enzymatic function, reduced cellular stress in the endoplasmic reticulum, improved lysosomal function and mitochondrial function, reduced toxic glycosphingolipids, aggregated -synuclein, neuroinflammation and neuronal death, increased dopamine levels and improved motor function. Currently, the drug is in Phase I trial for the treatment of Parkinson's disease.

* NNI 362: Neuronascent

NNI-362 is Neuronascent's patented oral therapeutic aimed at reversing age-related disorders by producing new neurons to replace those lost in chronic neurodegenerative disorders and aging. NNI-362 has a unique mechanism of action (MOA) that provides safety and selectivity specifically for neuron regeneration, and was discovered through Neuronascent's proprietary phenotypic screening program using human neural progenitors. This MOA takes advantage of the neural progenitors already in the aged brain to promote new neurons and protect them from degeneration in chronic diseases of the aged, specifically Alzheimer's disease. New neuron regeneration from neural progenitors is a physiologic process in the brain, yet with aging and neurodegenerative disease there begins a pathological insufficiency in generating new neurons that survive to functionality. Thus, NNI-362 is aimed at reversing age-related neuron loss and restoring cognitive function in AD patients, and should also be useful for other disorders of the elderly, including Parkinson's disease and age-related hearing loss. Currently, the drug is in preclinical stage for the treatment of Parkinson's disease.

The Parkinson's Disease Pipeline Report Provides Insights into-

* The report provides detailed insights about companies that are developing therapies for the treatment of Parkinson's Disease with aggregate therapies developed by each company for the same.
* It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Parkinson's Disease Treatment.
* Parkinson's Disease Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
* Parkinson's Disease Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
* Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Parkinson's Disease market

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Parkinson's Disease Companies

Annovis Bio, Cerevel Therapeutics, Roche, Inhibikase Therapeutics, Inc, Gain Therapeutics, Neuronascent, ANEW MEDICAL, Longevity Biotech, Minerva Neurosciences/Mitsubishi Tanabe Pharma Corporation, Tetraneuron, Kallyope, BlueRock Therapeutics LP, Neuraly, Peptron/Yuhan Corporation, Genentech, Kissei Pharmaceutical, Asklepios BioPharmaceutical, Alkahest, Modag, Intra-Cellular Therapies, Living Cell Technologies, MedImmune and others.

Parkinson's disease pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as

* Intravenous
* Subcutaneous
* Oral
* Intramuscular

Parkinson's Disease Products have been categorized under various Molecule types such as

* Monoclonal antibody
* Small molecule
* Peptide

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Scope of the Parkinson's Disease Pipeline Report

* Coverage- Global
* Parkinson's Disease Companies- Annovis Bio, Cerevel Therapeutics, Roche, Inhibikase Therapeutics, Inc, Gain Therapeutics, Neuronascent, ANEW MEDICAL, Longevity Biotech, Minerva Neurosciences/Mitsubishi Tanabe Pharma Corporation, Tetraneuron, Kallyope, BlueRock Therapeutics LP, Neuraly, Peptron/Yuhan Corporation, Genentech, Kissei Pharmaceutical, Asklepios BioPharmaceutical, Alkahest, Modag, Intra-Cellular Therapies, Living Cell Technologies, MedImmune and others.
* Parkinson's Disease Pipeline Therapies- VTX3232, Rasagiline, Safinamide Methanesulfonate, Levetiracetam, CTC-413, CVXL-0107, Levodopa, Rotigotine, Istradefylline 20 mg or 40 mg, IPX054 100 mg and others.
* Parkinson's Disease Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
* Parkinson's Disease Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

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Table of Contents

* Introduction
* Executive Summary
* Parkinson's disease : Overview
* Pipeline Therapeutics
* Therapeutic Assessment
* Parkinson's Disease- DelveInsight's Analytical Perspective
* Late Stage Products (Phase III)
* Buntanetap: Annovis Bio
* Drug profiles in the detailed report.....
* Mid Stage Products (Phase II)
* Risvodetinib: Inhibikase Therapeutics, Inc
* Drug profiles in the detailed report.....
* Early Stage Products (Phase I)
* GT 02287: Gain Therapeutics
* Drug profiles in the detailed report.....
* Preclinical and Discovery Stage Products
* NNI 362: Neuronascent
* Drug profiles in the detailed report.....
* Inactive Products
* Parkinson's disease Key Companies
* Parkinson's disease Key Products
* Parkinson's disease - Unmet Needs
* Parkinson's disease - Market Drivers and Barriers
* Parkinson's disease - Future Perspectives and Conclusion
* Parkinson's disease Analyst Views
* Parkinson's disease Key Companies
* Appendix

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