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KRAS Inhibitors Market Report on the Untapped Growth Opportunities in the Industry
According to the latest research by InsightAce Analytic, the Global KRAS Inhibitors Market Size is valued at USD 476.0 Mn in 2024 and is predicted to reach USD 2,916.8 Mn by the year 2034 at a 20.0% CAGR during the forecast period for 2025-2034.
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The KRAS gene encodes the K-Ras protein, a pivotal component of the RAS/MAPK signaling pathway. This pathway transmits signals from outside the cell to the nucleus, influencing cell proliferation, differentiation, and survival. Mutations in KRAS can lead to uncontrolled cell growth, contributing to the development of various cancers, including lung, colorectal, and pancreatic cancers.
Historically considered "undruggable," KRAS has become a focal point in oncology research. Recent breakthroughs have led to the development of small-molecule inhibitors targeting specific KRAS mutations, such as G12C and G12D. Notably, drugs like sotorasib and adagrasib have received FDA approval for treating non-small cell lung cancer (NSCLC) patients with KRAS G12C mutations. Additionally, emerging therapies like zoldonrasib have shown promise in early-phase clinical trials, demonstrating tumor shrinkage in patients with KRAS G12D mutations .
List of Prominent Players in the KRAS Inhibitors Market:
• Amgen
• Boehringer Ingelheim
• BridgeBio Pharma
• Erasca
• Innovent Biologics, Inc.
• Incyte
• Mirati Therapeutics
• Novartis
• Jemincare
• Cardiff Oncology, Inc.
• Roche
• Genentech
• Verastem Oncology
• Revolution Medicines
• Immuneering Corporation
• Jacobio Pharmaceuticals
• Deciphera Pharmaceuticals
• Elicio Therapeutics
• InventisBio
• Gritstone Bio
• D3 Bio
• Others
Market Dynamics:
Drivers-
The increasing demand for KRAS inhibitors is being propelled by the rising adoption of targeted therapies in oncology. These therapies have gained significant traction due to their precision and effectiveness in treating various forms of cancer. This report provides an in-depth analysis of the current therapeutic pipeline and explores the future trajectory of KRAS inhibitor research. It also presents comprehensive commercial insights into KRAS inhibitors currently available in the market and the overall pipeline landscape for this mechanism of action.
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Challenges:
The KRAS inhibitors market faces several notable challenges. Regulatory complexities, a shortage of skilled professionals, and the absence of standardized protocols-particularly in emerging economies-have created barriers to market growth. These issues were further intensified by the lockdowns and isolation measures brought about by the COVID-19 pandemic, which disrupted ongoing clinical trials.
Regional Trends:
North America is expected to lead the KRAS inhibitors market in terms of revenue and is projected to experience strong compound annual growth over the forecast period. This trend is primarily driven by increased investment in R&D and a rising incidence of cancers associated with KRAS mutations.
Europe also holds a considerable share of the market, underpinned by technological advancements and higher healthcare spending. Key factors supporting market expansion across these regions include the growing demand for targeted oncology therapies, improvements in healthcare infrastructure, a notable prevalence of KRAS mutations across cancer types, and the accelerating pace of drug discovery and clinical development.
Recent Developments:
• In October 2022, At the AACR annual meeting, Novartis presented encouraging clinical results for JDQ443, an experimental selective, covalent, and orally accessible KRASG12C inhibitor. A poster on Wednesday, April 13, and Cancer Discovery1 provide detailed information about JDQ443's discovery. JDQ443, discovered at Novartis, showed anti-tumor activity, high systemic exposure at its necessory dose, and a favorable safety profile in patients with KRAS G12C-mutated solid tumors in Phase Ib of the KontRASt-01 study (NCT04699188)2. In an oral session, the late-breaking abstract data will be presented.
• In September 2023, Amgen reported promising results from a specific part of the CodeBreaK 101 clinical trial, which is a Phase 1b research investigating the effectiveness of LUMAKRAS® (sotorasib) in combination with carboplatin and pemetrexed for treating adult patients with advanced non-small cell lung cancer (NSCLC) that contains a specific genetic mutation called KRAS G12C. The aforementioned findings were presented orally at the 2023 World Conference on Lung Cancer (WCLC), organized by the IASLC.
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Segmentation of KRAS Inhibitors Market-
By Cancer Type-
• Lung Cancer
• Pancreatic Cancer
• Colorectal Cancer
• Others
By End-Use-
• Clinic Laboratories
• Cancer Diagnostic Centers
• Hospitals
• Cancer Research Institutes
• Academic Institutions
• Others
By Region-
North America-
• The US
• Canada
• Mexico
Europe-
• Germany
• The UK
• France
• Italy
• Spain
• Rest of Europe
Asia-Pacific-
• China
• Japan
• India
• South Korea
• Southeast Asia
• Rest of Asia Pacific
Latin America-
• Brazil
• Argentina
• Rest of Latin America
Middle East & Africa-
• GCC Countries
• South Africa
• Rest of the Middle East and Africa
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About Us:
InsightAce Analytic is a market research and consulting firm that enables clients to make strategic decisions. Our qualitative and quantitative market intelligence solutions inform the need for market and competitive intelligence to expand businesses. We help clients gain a competitive advantage by identifying untapped markets, exploring new and competing technologies, segmenting potential markets, and repositioning products. Our expertise is in providing syndicated and custom market intelligence reports with an in-depth analysis with key market insights in a timely and cost-effective manner.https://www.insightaceanalytic.com/images_data/148861653.JPG
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