Press release
G-Protein Coupled Receptors Market Projected to Reach USD 6,965.93 Million by 2034, Growing at a CAGR of 6.02%
The G-Protein coupled receptors (GPCR) market report by Polaris Market Research provides a comprehensive market analysis, including size forecasts from 2025 to 2034. It examines key trends, primary growth drivers, and segmentation.
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How Much is the Market Expected to Grow?
In recent years, the G-protein coupled receptors market has experienced notable growth. It is expected to rise from USD 3,886.23 million to USD 6,965.93 million by 2034, reflecting a CAGR of 6.02% during 2025-2034. Various factors contribute to this growth, driven by increased investment and government support. The rising funding from both private and public sectors is fueling extensive research efforts to reveal new therapeutic targets linked to GPCRs. Furthermore, government programs designed to promote innovation in drug discovery are creating a strong foundation for technological progress in the field, boosting the market's growth potential.
What Are G-Protein Coupled Receptors?
GPCRs, sometimes called 7TM receptors, seven-pass transmembrane domain receptors, serpentine receptors, heptahelical receptors, and G protein-linked receptors (GPLR), are a vast and varied group of membrane proteins essential for cell signaling and communication. They function as "receivers" for cells, capturing signals from light, peptides, lipids, sugars, proteins, and other molecules. Upon binding with a ligand, a GPCR initiates a chain reaction of events that ultimately results in a change in the cell's activity.
Which Key Factors Are Driving the Market?
Rising Chronic and Lifestyle-Related Diseases
The rising prevalence of chronic and lifestyle-related diseases, such as diabetes, cardiovascular disorders, and respiratory illnesses, is fueling the demand for G-protein coupled receptors. GPCRs play a key role in regulating numerous vital biological pathways, making them valuable targets for therapeutic interventions in these widespread conditions.
Drug Discovery Technologies
Advancements in drug discovery technologies are driving the growth of the market. Innovations such as high-throughput screening, structure-based drug design, and computational modeling have significantly improved the ability to identify and optimize compounds targeting GPCRs. These technological breakthroughs are enhancing researchers' understanding of receptor behavior, improving drug efficacy predictions, and reducing both the time and costs involved in drug development.
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List of Key Companies
The companies listed below are the key players in the G-protein coupled receptors market. The companies hold the largest market share and impact the direction of industry trends. Here are some of the major companies operating in the market:
Alomone Labs
Abcam plc
Cisbio (Revvity)
Confo Therapeutics
DiscoverX (Eurofins)
Eurofins Scientific
Heptares Therapeutics (Sosei Group)
Merck KGaA
Molecular Devices
PerkinElmer Inc.
Promega Corporation
Sartorius (BellBrook Labs)
Tango Biosciences
Thermo Fisher Scientific Inc.
WuXi AppTec
G-Protein Coupled Receptors (GPCR) Industry Developments
November 2024 - Nxera Pharma (formerly Sosei Heptares) entered into a strategic partnership with AI-driven biotech company Antiverse to develop antibodies targeting GPCRs. The collaboration combines Nxera's expertise in GPCR biology with Antiverse's advanced AI platform to design agonistic antibodies for diseases with high unmet medical needs.
August 2024 - Ono Pharmaceutical expanded its partnership with Monash University to explore new GPCR targets for autoimmune and inflammatory diseases. Under the agreement, Ono secures exclusive global rights to develop and commercialize selected antibodies, with milestone-based and royalty payments dependent on development success.
July 2024 - Confo Therapeutics raised USD 65 million in Series B financing to advance four GPCR-targeting drug programs, including GPR75 for obesity. The funds will support ongoing Phase 1 clinical trials and IND (Investigational New Drug) submissions for both small molecules and agonistic antibody therapies.
Market Segmentation
By Product Outlook (Revenue, USD Million, 2020-2034)
● Cell Lines
● Detection Kits
● Cell Culture Reagents
● Ligands
By Assay Type Outlook (Revenue, USD Million, 2020-2034)
● cAMP Functional Assays
● Calcium Functional Assays
● β-Arrestin Functional Assays
● Radioligand Binding & GTPγS Functional Assays
● Internalization Assays
● Trafficking Assays
● Others
By Application Outlook (Revenue, USD Million, 2020-2034)
● Cancer Research
● CNS Research
● Metabolic Research
● Cardiovascular Research
● Respiratory Research
● Inflammation Research
● Others
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Regional Insights
The G-Protein Coupled Receptors (GPCR) market is analyzed across key regions, including North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.
North America led the market in terms of revenue share in 2024, driven by its advanced research infrastructure, significant investments in drug discovery, and the strong presence of leading pharmaceutical and biotechnology firms. The region continues to be a hub for innovation in GPCR research, supported by a dense network of academic institutions and research organizations.
In a notable development, Novartis announced in April 2025 an investment of USD 23 million over the next five years to expand its manufacturing and R&D capabilities in the United States. This includes the addition of 10 facilities-7 of which will be newly constructed-and the establishment of a research hub in San Diego. This move will enable full domestic production of key medicines and strengthen the region's role in GPCR-targeted drug development.
Additionally, North America's favorable regulatory environment and strong government and private sector funding for cutting-edge healthcare innovations continue to accelerate the commercialization of GPCR-based therapeutics.
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Polaris Market Research is a global market research and consulting company. The company specializes in providing exceptional market intelligence and in-depth business research services for PMR's clientele spread across different enterprises. We at Polaris are obliged to serve PMR's diverse customer base present across the industries of healthcare, technology, semiconductors, and chemicals among various other industries present around the world. We strive to provide PMR's customers with updated information on innovative technologies, high-growth markets, emerging business environments, and the latest business-centric applications, thereby helping them always to make informed decisions and leverage new opportunities. Adept with a highly competent, experienced, and extremely qualified team of experts comprising SMEs, analysts, and consultants, we at Polaris endeavor to deliver value-added business solutions to PMR's customers.
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