openPR Logo
Press release

Metastatic HR+/HER2- Breast Cancer Market Projected to Expand Significantly by 2034, Driven by Recent FDA Approvals and Emerging Targeted Therapies | DelveInsight

05-04-2025 02:02 PM CET | Business, Economy, Finances, Banking & Insurance

Press release from: ABNewswire

Metastatic HR+/HER2- Breast Cancer Market Projected to Expand

The metastatic HR+/HER2- breast cancer market is experiencing robust growth, fueled by an increasing patient pool and the introduction of innovative targeted therapies. Key breast cancer companies, such as Pfizer, Novartis, AstraZeneca, Roche, Arvinas, Olema Pharmaceuticals, Eli Lilly, and others, are shaping the treatment landscape for this most prevalent subtype of breast cancer.
DelveInsight's "Metastatic HR+/HER2- Breast Cancer Market Insights, Epidemiology, and Market Forecast-2034 [https://www.delveinsight.com/report-store/hr-positive-her2-negative-breast-cancer-market-insights?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=xpr]" report provides comprehensive insights into the historical and projected metastatic HR+/HER2 breast cancer epidemiology, treatment patterns, emerging therapies, and market trends across the 7MM. The HR+/HER2- breast cancer market size was nearly USD 10 billion across 7MM in 2023, which is expected to grow by 2034 with an increasing patient pool and the launch of potential emerging therapies.

Regionally, the US dominated the HR+/HER2- breast cancer market in 2023, with a market share of USD 7.5 billion, followed by the EU4, UK, and Japan. Furthermore, among the EU4 countries, Germany captured the largest market share.

Download the metastatic HR+/HER2- breast cancer market report to understand which factors are driving the metastatic HR+/HER2- breast cancer therapeutic market @ Metastatic HR+/HER2- Breast Cancer Market Trends [https://www.delveinsight.com/sample-request/hr-positive-her2-negative-breast-cancer-market-insights?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=xpr].

According to the metastatic HR+/HER2- breast cancer epidemiological analysis presented in the report, the total incident population of HR+/HER2- breast cancer was approximately 480K cases across 7MM in 2023, with the US accounting for the highest number at around 210K cases. The HR+/HER2- subtype represents approximately 70% of all breast cancer cases, making it the most prevalent form of breast cancer. Further, age-specific data shows that most HR+/HER2- breast cancer cases occur in people aged between 60 and 79 years, accounting for approximately 48% of all cases in the US in 2023.

Discover evolving trends in the metastatic HR+/HER2- breast cancer patient pool forecasts @ Metastatic HR+/HER2- Breast Cancer Epidemiology Analysis [https://www.delveinsight.com/sample-request/hr-positive-her2-negative-breast-cancer-market-insights?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=xpr].

The report also contains the current and emerging metastatic HR+/HER2- breast cancer treatment landscape. For the past decade, endocrine therapy has been the standard treatment for HR+/HER2- breast cancer in both early and advanced stages. FASLODEX, manufactured by AstraZeneca, is one of the most efficient and well-tolerated medications available in single-agent endocrine therapy formulations.

However, the introduction of CDK4/6 inhibitors such as palbociclib, ribociclib, and abemaciclib has recently revolutionized treatment approaches by providing extended progression-free survival when combined with endocrine therapy. IBRANCE, manufactured by Pfizer, led the market in 2023 with revenues reaching approximately USD 4.5 billion.

The metastatic HR+/HER2- breast cancer pipeline is robust, with numerous promising therapies in late-stage development. Key players, including Pfizer, Novartis, AstraZeneca, Roche, Arvinas, Olema Pharmaceuticals, Eli Lilly, and others, are advancing innovative candidates through clinical trials. Notable emerging therapies include ARV-471 (vepdegestrant), a PROTAC estrogen receptor protein degrader being developed by Arvinas and Pfizer; OP1250 (palazestrant), a complete estrogen receptor antagonist from Olema Pharmaceuticals; and Capivasertib, an AKT inhibitor from AstraZeneca.

The emerging pipeline is particularly rich in next-generation selective estrogen receptor degraders (SERDs), which aim to address the limitations of FASLODEX, including its poor bioavailability and inconvenient administration route. However, these novel SERDs will face strong competition from established CDK4/6 inhibitors, which currently hold significant market share, potentially limiting their initial growth.

Other promising drug classes in development include AKT inhibitors, mTOR inhibitors, PI3K inhibitors, and TROP-2 targeting antibody-drug conjugates, all of which are expected to expand the treatment armamentarium for patients with HR+/HER2- breast cancer.

Recent regulatory milestones have significantly impacted the treatment landscape. In January 2025, the FDA approved DATROWAY for unresectable or metastatic HR+/HER2- breast cancer in patients who have received prior endocrine-based therapy and chemotherapy. Simultaneously, ENHERTU received approval for unresectable or metastatic HR+/HER2-low or HER2-ultralow breast cancer that has progressed on one or more endocrine therapies in the metastatic setting.

Additionally, in January 2025, Roche announced positive topline results from the Phase III INAVO120 study investigating ITOVEBI in combination with IBRANCE and fulvestrant for patients with PIK3CA-mutated HR+/HER2-, endocrine-resistant, locally advanced or metastatic breast cancer.

In April 2024, the FDA accepted the Biologics License Application (BLA) for Dato-DXd, a TROP2 antibody-drug conjugate developed by AstraZeneca and Daiichi Sankyo, for the treatment of metastatic HR+/HER2- breast cancer, with a Prescription Drug User Fee Act (PDUFA) date set in July 2025.

Discover recent advancements in the metastatic HR+/HER2- breast cancer treatment landscape @Metastatic HR+/HER2- Breast Cancer Recent Developments [https://www.delveinsight.com/sample-request/hr-positive-her2-negative-breast-cancer-market-insights?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=xpr].

According to DelveInsight's analysis, the 5-year survival rate for HR+/HER2- breast cancer is approximately 96% for all stages combined, which is the highest among all breast cancer subtypes. However, this rate drops significantly to approximately 37% for patients with distant metastases, highlighting the continued need for more effective therapies for advanced disease. The introduction of novel targeted agents and combination approaches is expected to address this unmet need and further improve survival outcomes for patients with metastatic HR+/HER2- breast cancer.

As the HR+/HER2- breast cancer market continues to evolve, stakeholders across the healthcare ecosystem must stay informed about emerging therapies, changing treatment paradigms, and market dynamics. DelveInsight's comprehensive report offers valuable insights for pharmaceutical companies, healthcare providers, and patients navigating this complex and rapidly changing landscape.

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary of Metastatic HR+/HER2- Breast Cancer

4. Epidemiology and Market Forecast Methodology

5. Metastatic HR+/HER2- Breast Cancer Key Events

6. Metastatic HR+/HER2- Breast Cancer Market Overview at a Glance

7. Disease Background and Overview

8. Metastatic HR+/HER2- Breast Cancer Treatment

9. Metastatic HR+/HER2- Breast Cancer Epidemiology and Patient Population

10. Assumptions and Rationale

11. Metastatic HR+/HER2- Breast Cancer Patient Journey

12. Metastatic HR+/HER2- Breast Cancer Marketed Drugs

13. Metastatic HR+/HER2- Breast Cancer Emerging Therapies

14. HR+/HER2- Breast Cancer: The 7MM Analysis

15. Metastatic HR+/HER2- Breast Cancer Unmet needs

16. SWOT Analysis

17. KOL Views

18. Metastatic HR+/HER2- Breast Cancer Market Access and Reimbursement

19. Appendix

20. DelveInsight Capabilities

21. Disclaimer

22. About DelveInsight

About DelveInsight

DelveInsight is a leading market research and consulting firm specializing in disease-specific insights and therapeutic market analysis. Their reports integrate real-world data, clinical trial findings, and expert interviews to deliver comprehensive industry intelligence.

Media Contact
Company Name: DelveInsight Business Research LLP
Contact Person: Arpit Anand
Email:Send Email [https://www.abnewswire.com/email_contact_us.php?pr=metastatic-hrher2-breast-cancer-market-projected-to-expand-significantly-by-2034-driven-by-recent-fda-approvals-and-emerging-targeted-therapies-delveinsight]
Phone: +14699457679
Address:304 S. Jones Blvd #2432
City: Las Vegas
State: Nevada
Country: United States
Website: https://www.delveinsight.com/consulting/due-diligence-services

Legal Disclaimer: Information contained on this page is provided by an independent third-party content provider. ABNewswire makes no warranties or responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you are affiliated with this article or have any complaints or copyright issues related to this article and would like it to be removed, please contact retract@swscontact.com



This release was published on openPR.

Permanent link to this press release:

Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release Metastatic HR+/HER2- Breast Cancer Market Projected to Expand Significantly by 2034, Driven by Recent FDA Approvals and Emerging Targeted Therapies | DelveInsight here

News-ID: 3998272 • Views:

More Releases from ABNewswire

Tranquility Massage Recognized as Santa Barbara's Best Spa
10-01-2025 | Sports
ABNewswire
Tranquility Massage Recognized as Santa Barbara's Best Spa
Tranquility Massage Santa Barbara was recognized by California Coast Magazine as Santa Barbara's best spa, highlighting its consistent therapeutic care and serene, clientcentered experience. Santa Barbara, Calif. - Tranquility Massage Santa Barbara has been recognized by California Coast Magazine as the best spa in Santa Barbara [https://claude.ai/public/artifacts/632370bc-d2d6-4a9c-8542-b6b5211a12e9], reflecting sustained community enthusiasm for the studio's calm setting and consistent therapeutic care. The acknowledgement aligns with the studio's focus on straightforward, evidence-guided bodywork
Your Quality Pressure Washing Expands Fleet to Meet Houston's High Demand for Pressure Washing Services
Your Quality Pressure Washing Expands Fleet to Meet Houston's High Demand for Pr …
The need for professional pressure washing Houston services is particularly high due to the city's humid, subtropical climate. This environment accelerates the growth of mold, mildew, and algae on exterior surfaces, while constant construction in the growing metropolitan area creates additional dust and grime. In response to growing demand for professional exterior cleaning solutions, Your Quality Pressure Washing Houston has announced a significant expansion of its service fleet. This strategic investment
Market Outlook Projects Steady Growth for Luxury Custom Home Builders in 2025
Market Outlook Projects Steady Growth for Luxury Custom Home Builders in 2025
As families invest in properties that reflect their lifestyle and long-term goals, the role of custom home builders in Gulf Shores AL grows increasingly vital. The demand for luxury custom home builders [https://ddandbllc.com/custom-home-pool-builder-gulf-shores-al/] continues to rise across the United States, with Gulf Shores, AL, emerging as a key market for homeowners seeking elegance, comfort, and modern design. While many search for home builders near me, the region shows strong momentum fueled
Desman Orthodontics Launches
Desman Orthodontics Launches "Smiles for Students" Scholarship Orthodonist Servi …
For many families in the area, finding a trusted local provider is a priority. As an established orthodontist Port St Lucie families have relied on for years, Desman Orthodontics is uniquely positioned to understand the needs of the community. The practice's decision to create this scholarship stems from a recognition that a healthy, confident smile can have a profound impact on a young person's social development and self-esteem, yet it

All 5 Releases


More Releases for HR+/HER2

HR Positive/ HER2 Negative Breast Cancer Pipeline Outlook Report 2025: Extensive …
DelveInsight's, "HR Positive/ HER2 Negative Breast Cancer Pipeline Insight, 2025," report provides comprehensive insights about 50+ companies and 53+ pipeline drugs in HR Positive/ HER2 Negative Breast Cancer pipeline landscape. It covers the HR Positive/ HER2 Negative Breast Cancer pipeline drug profiles, including clinical and nonclinical stage products. It also covers the HR Positive/ HER2 Negative Breast Cancer pipeline therapeutics assessment by product type, stage, route of administration, and molecule
Metastatic HR+/HER2- Breast Cancer Market to Reach USD 39.8 Billion by 2034
Metastatic hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer is the largest clinical subtype of advanced breast cancer globally. It is traditionally managed with endocrine therapy; however, resistance-intrinsic or acquired-remains a central challenge. Over the last decade, the standard of care has shifted toward precision endocrine therapy combined with targeted agents (CDK4/6, PI3K, AKT, mTOR inhibitors) and, more recently, antibody-drug conjugates (ADCs) in later lines. Increasing reliance on genomic testing (e.g., ESR1
HR Positive/ HER2 Negative Breast Cancer FDA Approvals, MOA, ROA, Clinical Trial …
DelveInsight's, "HR Positive/ HER2 Negative Breast Cancer Pipeline Insight" report provides comprehensive insights about 50+ companies and 53+ pipeline drugs in HR Positive/ HER2 Negative Breast Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. Explore our latest
HR+ HER2-ve Breast Cancer Pipeline Therapeutics Assessment Report 2024 | DelveIn …
DelveInsight's, "HR Positive/ HER2 Negative Breast Cancer Pipeline Insight 2024" report provides comprehensive insights about 50+ companies and 53+ pipeline drugs in HR Positive/ HER2 Negative Breast Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. Explore our
HR Positive/ HER2 Negative Breast Cancer Pipeline Outlook Report 2024 (Updated)
DelveInsight's, "HR Positive/ HER2 Negative Breast Cancer-Pipeline Insight, 2024," report provides comprehensive insights about 50+ companies and 53+ pipeline drugs in HR Positive/ HER2 Negative Breast Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. Key Takeaways from the
HR Positive/ HER2 Negative Breast Cancer Pipeline Outlook Report 2024
DelveInsight's, "HR Positive/ HER2 Negative Breast Cancer Pipeline Insights 2024" report provides comprehensive insights about 50+ companies and 53+ pipeline drugs in HR Positive/ HER2 Negative Breast Cancer pipeline landscape. It covers the HR Positive/ HER2 Negative Breast Cancer pipeline drug profiles, including clinical and nonclinical stage products. It also covers the HR Positive/ HER2 Negative Breast Cancer pipeline therapeutics assessment by product type, stage, route of administration, and molecule