Alzheimer's disease Clinical and Non-Clinical Studies, Key Companies, Therapeutic Assessment, Emerging Therapies, Treatment Algorithm, and Pipeline Analysis | AriBio Co., Ltd., Eli Lilly & Co., Cognition Therapeutics, AbbVie Inc., Allyx Therapeutics, Inc.

Alzheimer's disease Pipeline constitutes 110+ key companies continuously working towards developing 120+ Alzheimer's disease treatment therapies, analyzes DelveInsight.

Alzheimer's disease Overview:

Alzheimer's disease (AD) is a condition that leads to the deterioration of brain cells and is the primary cause of dementia, which results in cognitive decline and a loss of independence in daily activities. AD is considered a complex disease with multiple contributing factors. Two main theories have been proposed to explain its development: the cholinergic hypothesis and the amyloid hypothesis. Additionally, various risk factors-including aging, genetic predisposition, head trauma, vascular conditions, infections, and environmental influences-contribute to the onset and progression of the disease.

AD is characterized by two types of neuropathological changes that help explain disease progression and symptoms. The first type includes **positive lesions**, which result from accumulations of neurofibrillary tangles, amyloid plaques, dystrophic neurites, neuropil threads, and other deposits in the brain. The second type consists of **negative lesions**, which involve significant brain atrophy due to the loss of neurons, synapses, and neuropil. Furthermore, additional mechanisms, such as neuroinflammation, oxidative stress, and damage to cholinergic neurons, contribute to neurodegeneration.

The symptoms of AD vary based on the disease stage. It is categorized into three phases: preclinical (or presymptomatic), mild, and dementia-stage, which differ from the DSM-5 classification of AD. The earliest and most prevalent symptom is episodic short-term memory loss, while long-term memory remains relatively intact in the beginning. Even if not the primary complaint, short-term memory impairment is typically detectable in most patients. As the disease progresses, individuals experience difficulties with problem-solving, judgment, executive functions, motivation, organization, multitasking, and abstract thinking. Executive function impairments range from mild to severe in the early stages, followed by language difficulties and visuospatial deficits.

In the middle and later stages, neuropsychiatric symptoms such as apathy, social withdrawal, agitation, disinhibition, psychosis, and wandering often emerge. Over time, patients may develop dyspraxia (difficulty performing learned motor tasks), olfactory dysfunction, sleep disturbances, and extrapyramidal symptoms such as dystonia, akathisia, and Parkinsonian-like features. In the final stages, primitive reflexes return, incontinence occurs, and patients become entirely dependent on caregivers for daily needs.

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"Alzheimer's disease Pipeline Insight 2025" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Alzheimer's disease Therapeutics Market.

Key Takeaways from the Alzheimer's disease Pipeline Report

DelveInsight's Alzheimer's disease pipeline report depicts a robust space with 110+ active players working to develop 120+ pipeline therapies for Alzheimer's disease treatment.
Key Alzheimer's disease companies such as AriBio Co., Ltd., Eli Lilly & Co., Cognition Therapeutics, AbbVie Inc., Allyx Therapeutics, Inc., Cassava Sciences, BioVie Inc., Novo Nordisk, Alector Inc., Longeveron Inc., Cognition Therapeutics, TrueBinding, Inc., VT BIO, Luye Pharma Group Ltd., Lexeo Therapeutics, Merck Sharp & Dohme LLC, Regeneration Biomedical, Alnylam Pharmaceuticals, Sinotau Pharmaceutical Group, Eisai Inc., Shanghai Hengrui Pharmaceutical Co., Ltd., and others are evaluating new drugs for Alzheimer's disease to improve the treatment landscape.
Promising Alzheimer's disease pipeline therapies in various stages of development include AR1001, NE3107, LY3372689, CT1812, ABBV-916, ALX-001, and others.

Recent breakthroughs in the Alzheimer's disease Pipeline Segment:

In January 2023, the U.S. Food and Drug Administration (FDA) granted accelerated approval for Leqembi, an amyloid beta-directed antibody targeting the underlying pathology of Alzheimer's disease by reducing amyloid plaques in the brain. This approval was based on early evidence suggesting potential clinical benefits.
In July 2023, the FDA converted Leqembi's status to traditional approval after a confirmatory Phase 3 clinical trial demonstrated its efficacy in slowing cognitive decline in patients with mild cognitive impairment or mild dementia due to AD.

Alzheimer's disease Pipeline Analysis
The report provides insights into:
The report provides detailed insights into the key companies that are developing therapies in the Alzheimer's disease Market.
The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Alzheimer's disease treatment.
It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Alzheimer's disease market.

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Alzheimer's disease Emerging Drugs

AR1001: AriBio Co., Ltd.
NE3107: BioVie
LY3372689: Eli Lilly & Co.
CT1812: Cognition Therapeutics
ABBV-916: AbbVie Inc.
ALX-001: Allyx Therapeutics, Inc.

Alzheimer's disease Companies

Around 110 companies are actively working on developing therapies for Alzheimer's disease. Among them, AriBio Co., Ltd. and BioVie have drug candidates that have reached the most advanced stage of development, Phase III clinical trials.

DelveInsight's report covers around 120+ products under different phases of clinical development like

Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates

Alzheimer's disease pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

Intravenous
Subcutaneous
Oral
Intramuscular

Alzheimer's disease Products have been categorized under various Molecule types such as

Monoclonal antibody
Small molecule
Peptide

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Alzheimer's disease Pipeline Therapeutic Assessment
• Alzheimer's disease Assessment by Product Type
• Alzheimer's disease By Stage
• Alzheimer's disease Assessment by Route of Administration
• Alzheimer's disease Assessment by Molecule Type

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Table of Content

1. Report Introduction
2. Executive Summary
3. Alzheimer's disease Current Treatment Patterns
4. Alzheimer's disease - DelveInsight's Analytical Perspective
5. Therapeutic Assessment
6. Alzheimer's disease Late-Stage Products (Phase-III)
7. Alzheimer's disease Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Alzheimer's disease Discontinued Products
13. Alzheimer's disease Product Profiles
14. Alzheimer's disease Key Companies
15. Alzheimer's disease Key Products
16. Dormant and Discontinued Products
17. Alzheimer's disease Unmet Needs
18. Alzheimer's disease Future Perspectives
19. Alzheimer's disease Analyst Review
20. Appendix
21. Report Methodology

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Contact Info:
Kritika Rehani
krehani@delveinsight.com
info@delveinsight.com
+14699457679

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

This release was published on openPR.