Pemphigus Vulgaris Drugs Market 2034: EMA, PDMA, FDA Approvals, Clinical Trials, Prevalence, NDA Approval, Revenue, Statistics, MOA, Therapies, Companies by DelveInsight

Pemphigus Vulgaris Companies are Roche, Cabaletta Bio, Principia Biopharma, Genentech, Inc., Kemia, Inc, argenx Rho Federal Systems Division, Inc, and others
(Albany, USA) DelveInsight's "Pemphigus Vulgaris Market Insights, Epidemiology, and Market Forecast-2034 report offers an in-depth understanding of the Pemphigus Vulgaris, historical and forecasted epidemiology as well as the Pemphigus Vulgaris market trends in the United States, EU4 (Germany, Spain, Italy, France) the United Kingdom and Japan.

The Pemphigus Vulgaris market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted Pemphigus Vulgaris market size from 2020 to 2034, segmented by seven major markets. The Report also covers current Pemphigus Vulgaris treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the Pemphigus Vulgaris market.

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Some of the key facts of the Pemphigus Vulgaris Market Report:

* The Pemphigus Vulgaris market size is anticipated to grow with a significant CAGR during the study period (2020-2034)
* The United States Pemphigus Vulgaris Market accounted for approximately USD 250 million in 2023.
* In January 2025, Cabaletta Bio announced results of a Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris
* In September 2024, IRIS Research and Development, LLC announced results of an Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.
* In August 2024, Treatment has begun for the first patient in an investigator-initiated basket trial (IIT) evaluating AlloNK Registered in combination with rituximab for conditions including rheumatoid arthritis, pemphigus vulgaris, granulomatosis with polyangiitis/microscopic polyangiitis, and systemic lupus erythematosus (SLE). This trial is being conducted by Integral Rheumatology & Immunology Specialists (IRIS), a community rheumatology clinic, highlighting the potential to provide AlloNK Registered to patients in community settings as well as in academic and transplant centers. The study aims to assess the safety, tolerability, and clinical efficacy of AlloNK Registered (also referred to as AB-101).
* Among the 7MM, the United States accounted for the highest number of cases of Pemphigus Vulgaris in 2023, with nearly 40,000 cases. These cases are anticipated to increase by 2034.
* The projections indicate the highest diagnosed prevalence of Pemphigus Vulgaris in the United States, with an estimated around 14,000 cases in the year 2022.
* Among the entire diagnosed population of nearly 14,000 Pemphigus Vulgaris cases in the United States, the highest incidence was identified in the age group of 60-69 years, while the lowest cases were observed in the 0-17 years age group in the year 2022.
* Pemphigus Vulgaris projections indicate that within the entire diagnosed prevalent population of Pemphigus Vulgaris in the US in 2022, around 6,000 cases were categorized as mild, 4,000 as moderate, and 4,300 accounted for severe cases.
* Within the EU4 and the UK, Germany reported the highest diagnosed prevalent population of Pemphigus Vulgaris, totaling around 8,000 cases, followed by the United Kingdom. In contrast, France had the lowest diagnosed prevalent population, with approximately 3,000 cases in 2022.
* Key Pemphigus Vulgaris Companies: Roche, Cabaletta Bio, Principia Biopharma, Genentech, Inc., Kemia, Inc, argenx Rho Federal Systems Division, Inc, and others
* Key Pemphigus Vulgaris Therapies: PRN1008, Mycophenolate Mofetil, KC706, efgartigimod PH20 SC, Moderna mRNA-1273, and others
* The Pemphigus Vulgaris epidemiology based on gender analyzed that a higher percentage of diagnosed prevalence was observed for females, in comparison to males, in all the 7MM countries during the study period (2020-2034)
* The Pemphigus Vulgaris market is expected to surge due to the disease's increasing prevalence and awareness during the forecast period. Furthermore, launching various multiple-stage Pemphigus Vulgaris pipeline products will significantly revolutionize the Pemphigus Vulgaris market dynamics.

Pemphigus Vulgaris Overview

Pemphigus vulgaris (PV) is a rare, chronic autoimmune blistering disorder affecting the skin and mucous membranes. It occurs when the immune system mistakenly produces autoantibodies against desmogleins, key proteins responsible for cell adhesion in the epidermis. This leads to the loss of cohesion between skin cells, causing fragile blisters and painful erosions.

Pemphigus vulgaris primarily affects middle-aged and older adults, with symptoms often beginning in the mouth before spreading to other parts of the body. The blisters are flaccid, rupture easily, and leave raw, painful sores that can increase the risk of infections and complications.

Pemphigus vulgaris Diagnosis is confirmed through clinical examination, skin biopsy, direct immunofluorescence, and serological tests detecting autoantibodies. Treatment mainly involves systemic corticosteroids and immunosuppressants, such as azathioprine, mycophenolate mofetil, or rituximab, to control the immune response. Advances in biologic therapies have improved disease management and reduced reliance on long-term steroid use.

While Pemphigus vulgaris is potentially life-threatening if left untreated, early diagnosis and proper treatment significantly improve outcomes. Long-term monitoring is essential to prevent relapses and manage side effects of immunosuppressive therapy. Ongoing research aims to develop targeted therapies to improve disease control with fewer adverse effects.

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Pemphigus Vulgaris Market Drivers and Barriers

The Pemphigus Vulgaris (PV) market is driven by increasing awareness, advancements in biologic therapies, and a rising prevalence of autoimmune disorders. The growing adoption of targeted therapies, such as rituximab, has significantly improved patient outcomes, reducing dependence on long-term corticosteroids and minimizing side effects. Additionally, ongoing research and development efforts, along with regulatory approvals for novel immunotherapies, are expanding treatment options. However, the market faces barriers such as the high cost of biologic drugs, limited availability of treatment in certain regions, and challenges in early diagnosis due to the rarity of the disease. The long-term use of immunosuppressive therapies also raises concerns regarding adverse effects, infections, and patient compliance. Furthermore, the small patient population poses a challenge for pharmaceutical companies in conducting large-scale clinical trials and achieving widespread commercial success. Despite these obstacles, increasing research investments and improved healthcare access are expected to drive market growth.

Pemphigus Vulgaris Epidemiology

The epidemiology section provides insights into the historical, current, and forecasted epidemiology trends in the seven major countries (7MM) from 2020 to 2034. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. The epidemiology section also provides a detailed analysis of the diagnosed patient pool and future trends.

Pemphigus Vulgaris Epidemiology Segmentation:

The Pemphigus Vulgaris market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM segmented into:

* Total Prevalence of Pemphigus Vulgaris
* Prevalent Cases of Pemphigus Vulgaris by severity
* Gender-specific Prevalence of Pemphigus Vulgaris
* Diagnosed Cases of Episodic and Chronic Pemphigus Vulgaris

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Pemphigus Vulgaris Drugs Uptake and Pipeline Development Activities

The drugs uptake section focuses on the rate of uptake of the potential drugs recently launched in the Pemphigus Vulgaris market or expected to get launched during the study period. The analysis covers Pemphigus Vulgaris market uptake by drugs, patient uptake by therapies, and sales of each drug.

Moreover, the therapeutics assessment section helps understand the drugs with the most rapid uptake and the reasons behind the maximal use of the drugs. Additionally, it compares the drugs based on market share.

The report also covers the Pemphigus Vulgaris Pipeline Development Activities. It provides valuable insights about different therapeutic candidates in various stages and the key companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

Pemphigus Vulgaris Therapies and Key Companies

* PRN1008: Principia Biopharma
* Mycophenolate Mofetil: Genentech, Inc.
* KC706: Kemia, Inc
* efgartigimod PH20 SC: argenx
* Moderna mRNA-1273: Rho Federal Systems Division, Inc

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Scope of the Pemphigus Vulgaris Market Report

* Study Period: 2020-2034
* Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]

* Key Pemphigus Vulgaris Companies: Roche, Cabaletta Bio, Principia Biopharma, Genentech, Inc., Kemia, Inc, argenx Rho Federal Systems Division, Inc, and others

* Key Pemphigus Vulgaris Therapies: PRN1008, Mycophenolate Mofetil, KC706, efgartigimod PH20 SC, Moderna mRNA-1273, and others
* Pemphigus Vulgaris Therapeutic Assessment: Pemphigus Vulgaris current marketed and Pemphigus Vulgaris emerging therapies
* Pemphigus Vulgaris Market Dynamics: Pemphigus Vulgaris market drivers and Pemphigus Vulgaris market barriers
* Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
* Pemphigus Vulgaris Unmet Needs, KOL's views, Analyst's views, Pemphigus Vulgaris Market Access and Reimbursement

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Table of Contents

1. Pemphigus Vulgaris Market Report Introduction

2. Executive Summary for Pemphigus Vulgaris

3. SWOT analysis of Pemphigus Vulgaris

4. Pemphigus Vulgaris Patient Share (%) Overview at a Glance

5. Pemphigus Vulgaris Market Overview at a Glance

6. Pemphigus Vulgaris Disease Background and Overview

7. Pemphigus Vulgaris Epidemiology and Patient Population

8. Country-Specific Patient Population of Pemphigus Vulgaris

9. Pemphigus Vulgaris Current Treatment and Medical Practices

10. Pemphigus Vulgaris Unmet Needs

11. Pemphigus Vulgaris Emerging Therapies

12. Pemphigus Vulgaris Market Outlook

13. Country-Wise Pemphigus Vulgaris Market Analysis (2020-2034)

14. Pemphigus Vulgaris Market Access and Reimbursement of Therapies

15. Pemphigus Vulgaris Market Drivers

16. Pemphigus Vulgaris Market Barriers

17. Pemphigus Vulgaris Appendix

18. Pemphigus Vulgaris Report Methodology

19. DelveInsight Capabilities

20. Disclaimer

21. About DelveInsight

About DelveInsight

DelveInsight is a leading Healthcare Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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