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What's Driving the Onpattro Market 2025-2034: Impact Of Rising Prevalence Of Hereditary Transthyretin-Mediated Amyloidosis On The Onpattro Market Growth

02-18-2025 02:44 PM CET | Health & Medicine

Press release from: The Business Research Company

Onpattro Market Size

Onpattro Market Size

How Is the Onpattro Market Projected to Grow, and What Is Its Market Size?
In recent times, the market size of onpattro has seen an $XX growth. The projections for this market suggest an increase from $XX million in 2024 to $XX million in 2025, indicating a compound annual growth rate (CAGR) of $XX%. Several contributing factors to the growth noted in the historical period include the increasing incidence of hereditary transthyretin-mediated amyloidosis, heightened awareness about rare diseases, boost in research and development investments, an expanding elderly population, and escalating spending in the healthcare sector.

Expectations suggest that the onpattro market will experience an $XX% surge in the next few years, expanding to a value of $XX million by 2029 at a Compound Annual Growth Rate (CAGR) of $XX%. This anticipated growth within the forecast duration can be ridden on the back of collaborative efforts and licensing, mandates from regulatory bodies, a rise in the instances of chronic illnesses, an upsurge in biopharmaceutical alliances, and the increasing rate of transthyretin amyloidosis cases. Key trends predicted during this forecasted phase involve an increased acceptance of ribonucleic acid-based treatments, the proliferation of orphan drug designations, the incorporation of digital health tools, a shift towards personalized healthcare, and technological breakthroughs in medication administration.

What Are the Key Drivers Behind the Growth of the Onpattro Market?
The growth of the onpattro market is anticipated to be propelled by the increased incidence of hereditary transthyretin-mediated amyloidosis. This rare genetic disorder results in mutated TTR proteins that form damaging deposits, adversely impacting nerves and the heart. Better diagnostic tools, genetic testing, and heightened awareness are leading to more identified cases, contributing to the rising incidence of this disorder. Onpattro is utilized in the treatment of hereditary transthyretin-mediated amyloidosis by impeding the activity of the transthyretin (TTR) gene, minimizing the production of amyloid protein and preventing damage to the organs. For example, in February 2024, Verywell Health, a US health information provider states that there are around 5,500-38,500 global cases of hereditary transthyretin-mediated amyloidosis, with US estimates varying from 104 to 3,847 cases which are diagnosed with associated polyneuropathy, emphasizing the significant underdiagnosis. Thus, the increasing incidence of hereditary transthyretin-mediated amyloidosis is fuelling onpattro market growth.

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Who Are the Major Industry Players Fueling Onpattro Market Expansion?
Major companies operating in the onpattro market include Alnylam Pharmaceuticals Inc.

What Are the Major Trends Shaping the Onpattro Market?
The prevailing trend within the onpattro market is concentrated on broadening the indications for the drug through ancillary drug applications, with a goal to optimize its market presence and cater to a larger group of patient requirements. The usual intent of supplemental drug applications is to pave the way for expanded approved usage of pharmaceuticals, targeting new indications, populations or formulations, thereby augmenting its therapeutic scope and market potential. For instance, Alnylam Pharmaceuticals, a US-based pharmaceutical firm, revealed the successful approval of a Supplemental New Drug Application (sNDA) for ONPATTRO (patisiran) in February 2023. This medication is designed to counter cardiomyopathy linked with transthyretin amyloidosis (ATTR). As an RNA interference (RNAi) therapeutic, ONPATTRO specifically targets the transthyretin (TTR) protein, which has a potential to abnormally build up in patients suffering from ATTR amyloidosis, causing serious complications such as cardiomyopathy. Originally approved in 2018 for treating polyneuropathy in relation to hereditary ATTR amyloidosis, the recent sNDA application was driven by the outcomes of the Phase III APOLLO-B study which revealed the notable effectiveness of patisiran in enhancing functional ability and life quality in patients having cardiomyopathy compared to a placebo.

How Is the Segmentation of the Onpattro Market Defined?
The onpattro market covered in this report is segmented -

1) By Clinical Indication: Hereditary Transthyretin-Mediated Amyloidosis, Wild-Type Transthyretin Amyloidosis, Other Transthyretin-Related Amyloidoses
2) By Distribution Channel: Direct Sales, Pharmacies, Online Pharmacies
3) By End User: Hospitals, Specialty Clinics, Home Healthcare Providers

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What Is the Leading Region in the Onpattro Market?
North America was the largest region in the onpattro market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the onpattro market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

What Is Covered In The Onpattro Global Market Report?

- Market Size Analysis: Analyze the onpattro Market Size by key regions, countries, product types, and applications.
- Market Segmentation Analysis: Identify various subsegments within the onpattro market for effective categorization.
- Key Player Focus: Focus on key players to define their market value, share, and competitive landscape.
- Growth Trends Analysis: Examine individual growth trends and prospects in the Market.
- Market Contribution: Evaluate contributions of different segments to the overall onpattro market growth.
- Growth Drivers: Detail key factors influencing market growth, including opportunities and drivers.
- Industry Challenges: Analyze challenges and risks affecting the onpattro market.
- Competitive Developments: Analyze competitive developments, such as expansions, agreements, and new product launches in the market.

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