Press release
Global Histone Deacetylase Inhibitors Market Projected to Surpass $1.77 Billion by 2029 with 7.9% Annual Growth
"What Are the Market Size and Growth Forecast for the Histone Deacetylase Inhibitors Market?In recent years, the market size for histone deacetylase inhibitors has seen robust growth. The market is projected to expand from $1.2 billion in 2024 to $1.3 billion in 2025, demonstrating a compound annual growth rate (CAGR) of 8.2%. The growth in the historic period was stimulated by factors like regulatory backing and swift approval processes, an increase in cancer cases, escalated funding for cancer research, broadening of therapeutic applications, and higher spending on healthcare infrastructure.
There is an anticipated robust expansion in the histone deacetylase inhibitors market in the coming years, with speculations of the market reaching $1.77 billion by 2029, reflecting a compound annual growth rate (CAGR) of 7.9%. This projected growth within the estimate period can be tied to the surge in biotechnology investment, an increasing elderly demographic, beneficial regulatory authorizations, expedited drug approvals, advancements in drug delivery systems, and broadening of therapeutic applications. The forecast period is set to witness significant trends such as the adoption of wearable technology for patient health tracking, progress in nanotechnology and drug delivery techniques, stride in the identification and validation of biomarkers, the emergence of artificial intelligence (AI) and machine learning and the advent of next-generation sequencing.
What Factors Are Propelling the Expansion of the Histone Deacetylase Inhibitors Market?
The growth of the histone deacetylase inhibitors market is anticipated to be boosted by the escalating rate of cancer. The predominance of cancer is generally ascribed to an aged society, heightened exposure to risk elements such as tobacco, diet, and pollutants in the environment, along with the advancement of diagnostic methods leading to earlier and more consistent detection. The treatment for cancer through histone deacetylase inhibitors involves the modulation of chromatin structure, igniting tumor suppressor genes and blocking oncogenes, which eventually results in cell cycle interruption and apoptosis in cancerous cells. For example, in February 2024, the World Health Organization, an intergovernmental body based in the US, predicted roughly 35 million fresh instances of cancer in 2050, showing an increase of 77% from the projected 20 million cases in 2022. Thus, the rising prevalence of cancer is fueling the expansion of the histone deacetylase inhibitors market.
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Which Key Market Leaders Are Driving Histone Deacetylase Inhibitors Industry Growth?
Major companies operating in the histone deacetylase inhibitors market are Merck & Co. Inc., AstraZeneca plc, Novartis AG, Eisai Co. Ltd., Aurobindo Pharma Limited, Karyopharm Therapeutics Inc., Syndax Pharmaceuticals Inc., MEI Pharma Inc., Italfarmaco S.p.A., Tokyo Chemical Industry Co. Ltd., InvivoGen Corp., Huya Bioscience International LLC, Crystal Genomics Inc., Spectrum Pharmaceuticals Inc., Curis Inc., Celgene Corporation, Celleron Therapeutics, Medivir AB, Onxeo SA, Regenacy Pharmaceuticals Inc., Shenzhen Chipscreen Biosciences Co. Ltd., Wellness Pharma International LLC, Forum Pharmaceuticals Inc., Midatech Pharma PLC
What Are the Emerging Trends in the Histone Deacetylase Inhibitors Industry?
Big firms in the histone deacetylase inhibitors market are prioritizing the creation of novel product formulas, like oral histone deacetylase (HDAC) inhibitors, in a bid to broaden treatment alternatives and enhance patient comfort and adherence. Oral histone deacetylase (HDAC) inhibitors, which are orally administered drugs targeting HDAC enzymes implicated in gene regulation, are potentially applicable in the treatment of diverse ailments, such as cancer and inflammatory diseases. For instance, in March 2024, Italfarmaco S.p.A., a pharmaceutical establishment based in Italy, secured Food and Drug Administration sanction for Duvyzat (givinostat), an oral HDAC suppressor intended for treating Duchenne muscular dystrophy (DMD) in patients over 6 years old. Duvyzat, an HDAC suppressor, counters the cascading events causing muscle damage, possibly reduces the worsening of muscle degeneration linked with DMD. By suppressing HDAC hyperactivity, it minimizes inflammation and fibrosis and stimulates muscle fiber rejuvenation. This approval is tethered to the decisive phase 3 EPIDYS trial that achieved its main goal, showing that patients on Duvyzat registered a statistically significant reduction in the time required to finish the four stair-climb assessment compared with placebo.
What Are the Main Segments in the Histone Deacetylase Inhibitors Market?
The histone deacetylase inhibitors market covered in this report is segmented -
1) By Classification: Class I Histone Deacetylases (HDACs), Class II Histone Deacetylases (HDACs), Class III Histone Deacetylases (HDACs), Other Classifications
2) By Route Of Administration: Oral, Injectable, Other Routes Of Administration
3) By Distribution Channel: Hospital Pharmacy, Online Pharmacy, Retail Pharmacy, Other Distribution Channels
4) By Application: Oncology, Neurology, Other Applications
5) By End Users: Hospitals, Homecare, Specialty Clinics, Other End Users
Suubsegments:
1) By Class I Histone Deacetylases (HDACs): HDAC1 Inhibitors, HDAC2 Inhibitors, HDAC3 Inhibitors, HDAC8 Inhibitors
2) By Class II Histone Deacetylases (HDACs): HDAC4 Inhibitors, HDAC5 Inhibitors, HDAC6 Inhibitors, HDAC7 Inhibitors, HDAC9 Inhibitors, HDAC10 Inhibitors
3) By Class III Histone Deacetylases (HDACs): Sirtuin 1 (SIRT1) Inhibitors, Sirtuin 2 (SIRT2) Inhibitors, Sirtuin 3 (SIRT3) Inhibitors, Sirtuin 4 (SIRT4) Inhibitors, Sirtuin 5 (SIRT5) Inhibitors, Sirtuin 6 (SIRT6) Inhibitors, Sirtuin 7 (SIRT7) Inhibitors
4) By Other Classifications: Dual-acting HDAC Inhibitors, Pan-HDAC Inhibitors, Selective HDAC Inhibitors, Combination Inhibitors (HDAC + Other Mechanisms)
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Which Geographic Area Leads the Histone Deacetylase Inhibitors Market?
North America was the largest region in the histone deacetylase inhibitors market in 2023. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the histone deacetylase inhibitors market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
What Is Covered In The Histone Deacetylase Inhibitors Global Market Report?
- Market Size Analysis: Analyze the Histone Deacetylase Inhibitors Market size by key regions, countries, product types, and applications.
- Market Segmentation Analysis: Identify various subsegments within the Histone Deacetylase Inhibitors Market for effective categorization.
- Key Player Focus: Focus on key players to define their market value, share, and competitive landscape.
- Growth Trends Analysis: Examine individual growth trends and prospects in the Market.
- Market Contribution: Evaluate contributions of different segments to the overall Histone Deacetylase Inhibitors Market growth.
- Growth Drivers: Detail key factors influencing market growth, including opportunities and drivers.
- Industry Challenges: Analyze challenges and risks affecting the Histone Deacetylase Inhibitors Market.
- Competitive Developments: Analyze competitive developments, such as expansions, agreements, and new product launches in the market.
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